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novel bioreactor Platform for reprOducible, Scalable ExpansIonand cardiac DifferentiatiON of hiPSC in suspension culture

Total Cost €


EC-Contrib. €






 POSEIDON project word cloud

Explore the words cloud of the POSEIDON project. It provides you a very rough idea of what is the project "POSEIDON" about.

cell    limited    fundamental    bioengineering    platform    effectiveness    standardised    cells    sectors    excellent    expansion    mass    impeller    scalability    poseidon    hipscs    types    indispensable    dependent    generation    career    track    outcomes    valuable    cultured    benefit    suspension    detrimental    stem    stresses    efficiency    regenerative    skills    tremendous    professional    tank    stirred    therapeutic    excellence    revolutionize    supervisor    industrial    enhanced    life    post    culture    bioreactor    quality    leadership    pluripotent    talented    aggregates    doc    record    engineering    pharmaceutical    ing    hydrodynamic    human    heterogeneity    researcher    reproducibility    widening    differentiation    competitiveness    purposely    fellowship    bioreactors    bioprocess    world    hipsc    sciences    scalable    utility    hubs    cardiomyogenic    standardisation    biomedical    purpose    expertise    designed    interdisciplinary    leader    pioneering    impose    perspectives    significantly    shear    bioprocessing    automated    biomedicine    group   

Project "POSEIDON" data sheet

The following table provides information about the project.


Organization address
address: Carl-Neuberg-Strasse 1
postcode: 30625

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Human induced pluripotent stem cells (hiPSCs) have the potential to revolutionize biomedical sciences, however the standardised mass production, indispensable for their industrial and therapeutic use, is still a major challenge. Impeller stirred-tank bioreactors, currently used for hiPSC bioprocessing, impose detrimental stresses on cultured hiPSCs, resulting in heterogeneity of cells and cell-aggregates, limited bioprocess reproducibility, and low hiPSC expansion efficiency at high costs. The ambitious purpose of the POSEIDON project is the development of a next-generation automated bioreactor platform to significantly improve reproducibility, efficiency and cost-effectiveness of scalable hiPSC expansion. To demonstrate the utility of the method for the production of valuable human cell types, a novel process for hiPSC-cardiomyogenic differentiation will also be established. This pioneering bioreactor will be developed by advanced engineering design methods and will enable controlled hiPSC suspension culture by non-impeller-dependent low-shear hydrodynamic conditions. Purposely designed automated systems will lead to bioprocess standardisation with enhanced reproducibility, efficiency and scalability beyond the state in the art. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, a talented post-doc with a significant track record in bioengineering, and the supervisor, a world leader in stem cell bioprocessing, whose group is embedded in one of Europe’s leading hubs for regenerative biomedicine. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in stem cell bioprocessing and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical and pharmaceutical sectors, contributing to the European excellence, competitiveness and quality of life.


year authors and title journal last update
List of publications.
2017 Diana Massai, Emiliano Bolesani, Diana Robles Diaz, Christina Kropp, Henning Kempf, Caroline Halloin, Ulrich Martin, Tudor Braniste, Giuseppe Isu, Vanessa Harms, Umberto Morbiducci, Gerald Dräger, Robert Zweigerdt
Sensitivity of human pluripotent stem cells to insulin precipitation induced by peristaltic pump-based medium circulation: considerations on process development
published pages: 1-15, ISSN: 2045-2322, DOI: 10.1038/s41598-017-04158-x
Scientific Reports 7/1 2019-06-18
2017 Isotta Chimenti, Diana Massai, Umberto Morbiducci, Antonio Paolo Beltrami, Maurizio Pesce, Elisa Messina
Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up
published pages: 150-166, ISSN: 1937-5387, DOI: 10.1007/s12265-017-9741-5
Journal of Cardiovascular Translational Research 10/2 2019-06-18
2017 Christina Kropp, Diana Massai, Robert Zweigerdt
Progress and challenges in large-scale expansion of human pluripotent stem cells
published pages: 244-254, ISSN: 1359-5113, DOI: 10.1016/j.procbio.2016.09.032
Process Biochemistry 59 2019-06-18

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