Opendata, web and dolomites

GABACODEV

Role of GABAergic microcircuits with different embryonic origins in the orchestration of early cortical dynamics in the awake mouse pup

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GABACODEV project word cloud

Explore the words cloud of the GABACODEV project. It provides you a very rough idea of what is the project "GABACODEV" about.

temporal    visualizing    crepel    indicating    allene    extended    postnatal    2009    unpublished    gaba    brain    dynamics    synchronizing    bonifazi    interneurons    ground    integrate    hippocampus    epilepsy    lab    shown    benefit    microcircuits    emergence    networks    cossart    single    host    neurons    2011    neocortex    axonal    cortical    mammals    situation    function    cells    experimentally    2013    le    complexity    disruption    microscopy    manipulating    et    vitro    tools    picardo    murine    hub    wiring    vivo    al    because    functional    gabaergic    unknown    connectivity    maturation    operate    transmission    genetic    handedly    developmental    plays    combining    mouse    shapes    generally    moyner    sequence    contribution    2007    divergent    time    participate    hippocampal    circuitry    solid    builds    network    correlated    maguerise    patterns    subpopulation    neuronal    diverse    points    multidisciplinary    translating    schizophrenia    data    dynamicsthis    populations    precise    slices    disorders    generation    autism    2008    awake   

Project "GABACODEV" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.inmed.fr/developpement-des-microcircuits-gabaergiques-corticaux-fr
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 173˙076.00

Map

 Project objective

Because of its function in brain wiring and in the generation of early correlated activity patterns, the maturation of GABAergic transmission plays a key role in enabling brain complexity in higher mammals. Indeed, disruption of GABAergic circuitry at several time points can contribute to the generation of developmental disorders such as schizophrenia, autism or epilepsy (Le Maguerise and Moyner, 2013). Both in the murine hippocampus and neocortex, GABAergic interneurons have been shown to participate in the emergence of a precise temporal sequence of distinct correlated neuronal activity patterns during early postnatal development (Crepel et al., 2007; Allene et al., 2008). In particular, GABAergic cells with an extended and divergent axonal connectivity (operational “hub” neurons) (Bonifazi et al., 2009; Picardo et al., 2011; Cossart, 2013) have been described to be capable of synchronizing single-handedly populations of cells in developing hippocampal slices (Bonifazi et al., 2009). This project builds up on a solid ground of unpublished in vitro data from the host lab indicating that a specific, but diverse functional subpopulation of GABA neurons could also operate as hub cells in the developing neocortex. Experimentally, it will benefit from recent technical developments from the host lab aiming at manipulating and visualizing the activity of single neurons in the awake mouse combining genetic and microscopy tools. Indeed, if operational hub neurons have been described in vitro, it remains unknown how they integrate into functional networks in vivo, and more generally how GABAergic activity shapes early cortical network dynamicsThis proposal aims at translating from the in vitro to the in vivo situation a multidisciplinary approach to investigate the functional contribution of specific microcircuits to the emergence of network dynamics during development.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GABACODEV" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GABACODEV" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

DIGILEAD (2020)

Digital leadership, well-being and performance in organizations

Read More  

CLIMACY (2020)

Practices of Climate Diplomacy and Uneven Policy Responses on Climate Change on Human Mobility

Read More  

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More