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OBEDIA-MARK SIGNED

EPIGENETIC MARKERS OF DISEASE STATUS AND REVERSAL FOR PERSONALIZED MANAGEMENT OF OBESITY AND DIABETES

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "OBEDIA-MARK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 243˙208 €
 EC max contribution 243˙208 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-06-20   to  2019-06-19

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 243˙208.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

Epigenetic marks such as DNA methylation (DNAm) can store cell memories of past life experiences. Thanks to this property, these marks hold great potential as biomarkers for personalized management of diseases arising from gene-environment interactions such as obesity and associated disorders. However, realizing this potential requires large-scale longitudinal studies that evaluate epigenetic markers under consideration of pertinent lifestyle and genetic factors. The goal of the proposed project is to fill this research gap by identifying, for the first time in a large-scale longitudinal study, epigenetic biomarkers of disease status and reversal for personalized management of obesity and diabetes. To attain this goal I will i) Identify overweight -associated DNAm markers by comparing DNAm patterns of 400 obese subjects before and after a randomized controlled weight-loss intervention, ii) Assess the relationship of the identified markers with gene-diet interactions, and their reversibility in response to weight-loss, iii) Test the validity of these markers, alone and in combination with genetic analysis, as biomarkers for prediction of weight-loss performance and diabetes status/reversal.

Expected outcomes: I) Drive innovation in personalized medicine by identifying epigenetic markers of disease status and reversal in obesity and diabetes, ii) Expand our understanding of how epigenetic, genetic and dietary factors interact with each other in the development and reversal of obesity, iii) Equip me with the knowledge and skills needed to become an independent scientist. The quality of the research, hosting arrangements and collaborations will provide me with the best opportunities to expand my expertise in epigenetics, apply it to research on human disease, and reinforce my professional maturity for securing a faculty position in Europe.

 Publications

year authors and title journal last update
List of publications.
2019 Cynthia W Shih, Michelle E Hauser, Lucia Aronica, Joseph Rigdon, Christopher D Gardner
Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial
published pages: 433-441, ISSN: 0002-9165, DOI: 10.1093/ajcn/nqy305
The American Journal of Clinical Nutrition 109/2 2019-10-17
2019 Cynthia W Shih, Michelle E Hauser, Lucia Aronica, Joseph Rigdon, Christopher D Gardner
Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial
published pages: 433-441, ISSN: 0002-9165, DOI: 10.1093/ajcn/nqy305
The American Journal of Clinical Nutrition 109/2 2019-06-06

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The information about "OBEDIA-MARK" are provided by the European Opendata Portal: CORDIS opendata.

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