Explore the words cloud of the NoiseRobustEvo project. It provides you a very rough idea of what is the project "NoiseRobustEvo" about.
The following table provides information about the project.
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙383˙444 €|
|EC max contribution||2˙383˙444 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-10-01 to 2022-09-30|
Take a look of project's partnership.
|1||UNIVERSITAT ZURICH||CH (Zürich)||coordinator||2˙383˙444.00|
Living cells are constantly barraged by perturbations that originate within themselves. Especially abundant – far more than DNA mutations – are two kinds of such perturbations. The first is gene expression noise, pervasive stochastic variation of transcript and protein levels. The second is mistranslation noise, the misincorporation of amino acids by ribosomes during protein synthesis. Organisms and protein molecules can evolve robustness – the persistence of well-adapted phenotypes – to both kinds of noise. Theory predicts that noise and robustness can affect the adaptive evolution of new proteins, but we do not know whether they help or hinder adaptive evolution. We hypothesize that noise and robustness can accelerate protein evolution both separately and jointly. To validate this hypothesis, we will evolve light-emitting fluorescent proteins towards new color phenotypes via directed laboratory evolution in E.coli. During evolution, we will manipulate expression noise by driving FP expression from noisy or quiet promoters, and we will manipulate mistranslation via host strains with low and high mistranslation rates. We will manipulate protein robustness in three biologically important ways, chaperone overexpression, gene duplication, and stabilizing selection. We will study how fast FPs evolve new colors, and analyze protein evolutionary dynamics through a combination of high-throughput sequencing, engineering of selected adaptive mutations, and data-driven modeling. Our project will show how a ubiquitous but poorly understood source of phenotypic variation affects protein innovation. It will also help engineers discover new protein functions. Moreover, our work will help establish FPs as a major platform to study protein evolutionary dynamics. By revealing noise as a new and crucial factor in protein evolution, our observations have the potential to revolutionize molecular evolution research, much like earlier studies of noise have revolutionized cell biology.
|year||authors and title||journal||last update|
Jia Zheng, Joshua L. Payne, Andreas Wagner
Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks
published pages: 347-353, ISSN: 0036-8075, DOI: 10.1126/science.aax1837
Aguilar-RodrÃguez, JosÃ©; Fares, Mario A; Wagner, Andreas
Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli
published pages: , ISSN: 0378-1097, DOI: 10.5167/uzh-182142
|Aguilar-RodrÃguez, JosÃ©; Fares, Mario A; Wagner, Andreas (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10):fnz121. 1||2020-04-15|
Joshua L. Payne, Andreas Wagner
The causes of evolvability and their evolution
published pages: 24-38, ISSN: 1471-0056, DOI: 10.1038/s41576-018-0069-z
|Nature Reviews Genetics 20/1||2020-04-15|
Payne, Joshua L; Khalid, Fahad; Wagner, Andreas
RNA-mediated gene regulation is less evolvable than transcriptional regulation
published pages: , ISSN: 1091-6490, DOI: 10.5167/uzh-167214
Aguilar-RodrÃguez, JosÃ©; Peel, Leto; Stella, Massimo; Wagner, Andreas; Payne, Joshua L.
The architecture of an empirical genotype-phenotype map
published pages: , ISSN: 1558-5646, DOI: 10.3929/ethz-b-000274406
|Evolution, 72 (6) 11||2019-06-06|
Kathleen Sprouffske, JosÃ© Aguilar-RodrÃguez, Paul Sniegowski, Andreas Wagner
High mutation rates limit evolutionary adaptation in Escherichia coli
published pages: e1007324, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007324
|PLOS Genetics 14/4||2019-06-06|
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