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ROSNPD

Selective vulnerability of neuronal degeneration in Parkinson’s disease: the load of routine behaviour

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ROSNPD project word cloud

Explore the words cloud of the ROSNPD project. It provides you a very rough idea of what is the project "ROSNPD" about.

ca    substantia    sensitivity    onset    switching    emotional    anatomical    phasically    oxidative    defines    reward    degeneration    modulation    metabolic    region    stimuli    begins    tonic    posterior    pars    functional    depletion    arborisations    parkinson    demand    earliest    vulnerability    dependent    triggered    habitual    salience    habit    damage    behaviours    neurodegeneration    notion    neurons    lateral    underlying    dopamine    hypothesized    automatic    external    engaged    directed    susceptible    striatum    learning    perhaps    start    behavioural    first    firing    snpc    shared    nigra    primary    foremost    released    stress    movements    predominates    cell    regulates    axonal    overload    bursting    compacta    offset    activation    dopaminergic    alertness    consequent    precise    unmet    signals    impairment    instrumental    tier    da    spectrum    rate    sensory    whereby    provides    striatal    mechanisms    aging    mechanism    showing    inflow    disease    occurs    motor    routine    progression    ventro    pd    whereas   

Project "ROSNPD" data sheet

The following table provides information about the project.

Coordinator
FUNDACION INVESTIGATION HM HOSPITALES 

Organization address
address: PLAZA DEL CONDE DE VALLE SUCHIL, N 2, PLANTA 1
city: MADRID
postcode: 28015
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-11-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION INVESTIGATION HM HOSPITALES ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Parkinson’s disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc).Understanding the mechanisms underlying the onset and progression of SNpc damage is a primary unmet goal in PD research.Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc.Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc:their large axonal arborisations,bursting activity with high Ca\ inflow,high oxidative stress and sensitivity to aging.However, all of these features are shared by SNpc neurons but neurodegeneration in PD begins specifically by the ventro-lateral tier. This DA depletion first occurs in the posterior striatum, which is involved and required for habit formation and routine behaviour.Indeed, the earliest motor features of PD are commonly associated with impairment of automatic movements.The striatum is well known to be engaged in learning and habit formation,a process that is DA dependent.Striatal DA is released phasically (SNpc firing related) triggered by emotional responses,whereas tonic dopaminergic modulation (non-SNpc firing related),predominates in routine behaviour. The precise mechanism whereby DA regulates the learning of a routine is not well defined but SNpc dopaminergic neurons are engaged in behavioural tasks showing an activation of their firing rate at the start of an instrumental task. This provides support to the notion that DA signals the onset/offset of a task and perhaps switching between tasks.In addition, they have a higher response to external stimuli (alertness, sensory) and to emotional behaviours (i.e. reward, salience). It is hypothesized here that in order to control the whole spectrum of a task, from goal directed to habitual, the ventro-lateral SNpc neurons are under higher functional demand, and the consequent metabolic overload makes them more susceptible to degeneration.

 Publications

year authors and title journal last update
List of publications.
2017 Marcelo Mendonça; Joaquim Alves da Silva; Ledia F. Hernandez; Jose Obeso; Rui Costa.
Neural correlates of movement sequence kinematics in substantia nigra dopaminergic cells
published pages: , ISSN: , DOI:
Movement Disorders Vol. 32, Suppl 2 2019-05-20
2018 Ledia F. Hernandez; Marcelo Mendonca; Joaquim Alves da Silva; Ivan Castela; Jose Obeso; Rui Costa.
Neural correlates of dopaminergic activity by calcium imaging in the SNpc during a skilled movement task
published pages: Abstract: 4124, ISSN: , DOI:
FENS18_ Abstracts Book 2019-05-20
2018 Marcelo Mendonca; Joaquim Alves da Silva; Ledia F. Hernandez; Ivan Castela; Jose Obeso; Rui Costa.
Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences
published pages: S400, ISSN: , DOI:
Movement Disorders Volume 33, Issue S2 2019-05-20

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