EU H2020 Project "ROSNPD (Selective vulnerability of neuronal degeneration in Parkinson’s..)": description, partecipants, costs and EC-fundings

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ROSNPD project word cloud

Explore the words cloud of the ROSNPD project. It provides you a very rough idea of what is the project "ROSNPD" about.

predominates depletion instrumental behaviours nigra earliest stimuli motor triggered cell released stress regulates dopamine axonal substantia start functional signals hypothesized overload dopaminergic activation rate emotional progression region perhaps tonic unmet sensory showing dependent underlying anatomical notion oxidative tier consequent provides first routine external compacta onset shared directed disease automatic firing mechanism mechanisms reward occurs neurodegeneration begins whereby da pd switching inflow modulation damage primary parkinson striatum vulnerability foremost posterior behavioural spectrum pars aging salience precise snpc demand metabolic striatal bursting learning ca habit degeneration neurons susceptible alertness lateral ventro movements impairment arborisations offset engaged whereas phasically sensitivity habitual defines

Project "ROSNPD" data sheet

The following table provides information about the project.

Coordinator	FUNDACION INVESTIGATION HM HOSPITALES Organization address address: PLAZA DEL CONDE DE VALLE SUCHIL, N 2, PLANTA 1 city: MADRID postcode: 28015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	170˙121 €
EC max contribution	170˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-RI
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2018-11-01

#	participants	country	role	EC contrib. [€]
1	FUNDACION INVESTIGATION HM HOSPITALES	ES (MADRID)	coordinator	170˙121.00

FUNDACION INVESTIGATION HM HOSPITALES

ES (MADRID)

coordinator

170˙121.00

Project objective

Parkinson’s disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc).Understanding the mechanisms underlying the onset and progression of SNpc damage is a primary unmet goal in PD research.Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc.Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc:their large axonal arborisations,bursting activity with high Ca\ inflow,high oxidative stress and sensitivity to aging.However, all of these features are shared by SNpc neurons but neurodegeneration in PD begins specifically by the ventro-lateral tier. This DA depletion first occurs in the posterior striatum, which is involved and required for habit formation and routine behaviour.Indeed, the earliest motor features of PD are commonly associated with impairment of automatic movements.The striatum is well known to be engaged in learning and habit formation,a process that is DA dependent.Striatal DA is released phasically (SNpc firing related) triggered by emotional responses,whereas tonic dopaminergic modulation (non-SNpc firing related),predominates in routine behaviour. The precise mechanism whereby DA regulates the learning of a routine is not well defined but SNpc dopaminergic neurons are engaged in behavioural tasks showing an activation of their firing rate at the start of an instrumental task. This provides support to the notion that DA signals the onset/offset of a task and perhaps switching between tasks.In addition, they have a higher response to external stimuli (alertness, sensory) and to emotional behaviours (i.e. reward, salience). It is hypothesized here that in order to control the whole spectrum of a task, from goal directed to habitual, the ventro-lateral SNpc neurons are under higher functional demand, and the consequent metabolic overload makes them more susceptible to degeneration.

Publications

List of publications.
year	authors and title	journal	last update
2017	Marcelo MendonÃ§a; Joaquim Alves da Silva; Ledia F. Hernandez; Jose Obeso; Rui Costa. Neural correlates of movement sequence kinematics in substantia nigra dopaminergic cells published pages: , ISSN: , DOI:	Movement Disorders Vol. 32, Suppl 2	2019-05-20
2018	Ledia F. Hernandez; Marcelo Mendonca; Joaquim Alves da Silva; Ivan Castela; Jose Obeso; Rui Costa. Neural correlates of dopaminergic activity by calcium imaging in the SNpc during a skilled movement task published pages: Abstract: 4124, ISSN: , DOI:	FENS18_ Abstracts Book	2019-05-20
2018	Marcelo Mendonca; Joaquim Alves da Silva; Ledia F. Hernandez; Ivan Castela; Jose Obeso; Rui Costa. Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences published pages: S400, ISSN: , DOI:	Movement Disorders Volume 33, Issue S2	2019-05-20

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