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ROSNPD

Selective vulnerability of neuronal degeneration in Parkinson’s disease: the load of routine behaviour

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ROSNPD project word cloud

Explore the words cloud of the ROSNPD project. It provides you a very rough idea of what is the project "ROSNPD" about.

dopaminergic    snpc    consequent    progression    arborisations    spectrum    stimuli    sensitivity    regulates    susceptible    tonic    switching    earliest    whereby    start    phasically    learning    foremost    vulnerability    sensory    notion    neurons    neurodegeneration    occurs    stress    lateral    da    salience    rate    provides    pd    anatomical    cell    degeneration    unmet    oxidative    functional    depletion    dopamine    bursting    disease    axonal    routine    motor    automatic    firing    behaviours    inflow    signals    offset    engaged    parkinson    overload    activation    compacta    triggered    defines    ventro    impairment    posterior    hypothesized    striatum    released    habitual    mechanisms    behavioural    movements    whereas    emotional    habit    predominates    striatal    first    pars    metabolic    region    reward    primary    ca    showing    modulation    substantia    alertness    begins    underlying    instrumental    directed    shared    precise    onset    damage    mechanism    nigra    external    aging    demand    perhaps    dependent    tier   

Project "ROSNPD" data sheet

The following table provides information about the project.

Coordinator
FUNDACION INVESTIGATION HM HOSPITALES 

Organization address
address: PLAZA DEL CONDE DE VALLE SUCHIL, N 2, PLANTA 1
city: MADRID
postcode: 28015
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2018-11-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION INVESTIGATION HM HOSPITALES ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Parkinson’s disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc).Understanding the mechanisms underlying the onset and progression of SNpc damage is a primary unmet goal in PD research.Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc.Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc:their large axonal arborisations,bursting activity with high Ca\ inflow,high oxidative stress and sensitivity to aging.However, all of these features are shared by SNpc neurons but neurodegeneration in PD begins specifically by the ventro-lateral tier. This DA depletion first occurs in the posterior striatum, which is involved and required for habit formation and routine behaviour.Indeed, the earliest motor features of PD are commonly associated with impairment of automatic movements.The striatum is well known to be engaged in learning and habit formation,a process that is DA dependent.Striatal DA is released phasically (SNpc firing related) triggered by emotional responses,whereas tonic dopaminergic modulation (non-SNpc firing related),predominates in routine behaviour. The precise mechanism whereby DA regulates the learning of a routine is not well defined but SNpc dopaminergic neurons are engaged in behavioural tasks showing an activation of their firing rate at the start of an instrumental task. This provides support to the notion that DA signals the onset/offset of a task and perhaps switching between tasks.In addition, they have a higher response to external stimuli (alertness, sensory) and to emotional behaviours (i.e. reward, salience). It is hypothesized here that in order to control the whole spectrum of a task, from goal directed to habitual, the ventro-lateral SNpc neurons are under higher functional demand, and the consequent metabolic overload makes them more susceptible to degeneration.

 Publications

year authors and title journal last update
List of publications.
2017 Marcelo Mendonça; Joaquim Alves da Silva; Ledia F. Hernandez; Jose Obeso; Rui Costa.
Neural correlates of movement sequence kinematics in substantia nigra dopaminergic cells
published pages: , ISSN: , DOI:
Movement Disorders Vol. 32, Suppl 2 2019-05-20
2018 Ledia F. Hernandez; Marcelo Mendonca; Joaquim Alves da Silva; Ivan Castela; Jose Obeso; Rui Costa.
Neural correlates of dopaminergic activity by calcium imaging in the SNpc during a skilled movement task
published pages: Abstract: 4124, ISSN: , DOI:
FENS18_ Abstracts Book 2019-05-20
2018 Marcelo Mendonca; Joaquim Alves da Silva; Ledia F. Hernandez; Ivan Castela; Jose Obeso; Rui Costa.
Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences
published pages: S400, ISSN: , DOI:
Movement Disorders Volume 33, Issue S2 2019-05-20

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