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Vaprosep

Validation of Progranulin as Biomarker in Diagnostics and Prognosis of Sepsis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Vaprosep project word cloud

Explore the words cloud of the Vaprosep project. It provides you a very rough idea of what is the project "Vaprosep" about.

reaction regarding market complete 1000 routine validated agent therapeutic time solidity 12 advantages preliminary health incidence completion hospitals multiplex mediagnost million systemic rate progranulin day opinion prognosis differentiation validation stay qualified scientific mean leaders clinical bodies infection inflammatory worldwide prove guarantee disease successfully subsequent point strategy technically data employees regulatory avoidance direct unnecessary feasibility sepsis host sensitive picture literature reduce reimbursement patient icu strategic notified interviewed care successful monitoring detection inducing 094 property contact economic length therapy biomarker delay antibiotic administrative course questionnaire excellent intellectual hospital structured infectious 500 infrastructure

Project "Vaprosep" data sheet

The following table provides information about the project.

Coordinator	MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH Organization address address: ASPENHAUSTRASSE 25 city: REUTLINGEN postcode: 72770 website: www.mediagnost.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.mediagnost.de/en/news/summary-of-sme-instrument-phase-i-project-vaprosep-2/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SMEINST-1-2014
Funding Scheme	SME-1
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2015-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH Organization address address: ASPENHAUSTRASSE 25 city: REUTLINGEN postcode: 72770 website: www.mediagnost.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REUTLINGEN)	coordinator	50˙000.00

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Project objective

Sepsis is a complex, systemic and inflammatory host reaction on an infection and with worldwide 1.5 million cases per year a health challenge. There is a strong need for a reliable biomarker like progranulin. Preliminary data prove that progranulin allows a highly sensitive and specific detection of sepsis, a monitoring of infection without time delay, prognosis regarding disease course and a differentiation between the infectious agent inducing sepsis.

Economic advantages of progranulin as biomarker are the reduction of the length of stay in the ICU (500-1000€ / day) and avoidance of unnecessary antibiotic therapy (10-500€ / day). Thus, the hospital can improve patient care and reduce therapeutic costs by a progranulin measurement for 5-10€. A mean incidence rate of 0.094% results in a 12 million euro market in the US and EU. Based on intellectual property this market is available only for Mediagnost. Successfully validated, progranulin measurement will be introduced in third level hospitals in the EU. The subsequent strategic product development includes point of care and multiplex test systems.

Mediagnost already has a technically validated test system for this biomarker available, therefore the overall objectives of this study are the clinical validation of progranulin measurement in sepsis and its implementation in clinical routine. Specifically, in phase I the economic potential of this biomarker is evaluated.

These objectives are addressed during phase I in a feasibility study including market and cost analysis. Key opinion leaders in the EU are interviewed by a structured questionnaire to evaluate scientific solidity and market potential. In direct contact to EU Notified Bodies the best regulatory strategy is evaluated. Further, literature research will complete the picture of the market and reimbursement requirements. Excellent infrastructure and highly qualified scientific and administrative employees guarantee the successful completion of this work.

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The information about "VAPROSEP" are provided by the European Opendata Portal: CORDIS opendata.

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