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Vaprosep

Validation of Progranulin as Biomarker in Diagnostics and Prognosis of Sepsis

Total Cost €

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EC-Contrib. €

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Partnership

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 Vaprosep project word cloud

Explore the words cloud of the Vaprosep project. It provides you a very rough idea of what is the project "Vaprosep" about.

delay    detection    picture    prove    successfully    infectious    disease    time    technically    mediagnost    biomarker    host    opinion    progranulin    point    health    administrative    rate    employees    economic    advantages    prognosis    infrastructure    market    clinical    500    structured    feasibility    094    therapy    therapeutic    antibiotic    leaders    excellent    data    multiplex    regarding    infection    icu    questionnaire    notified    literature    hospital    validated    incidence    complete    strategic    care    reduce    scientific    mean    avoidance    unnecessary    regulatory    length    12    hospitals    monitoring    qualified    successful    sensitive    strategy    property    day    bodies    validation    systemic    differentiation    intellectual    stay    patient    completion    interviewed    solidity    million    preliminary    direct    subsequent    course    worldwide    1000    sepsis    inflammatory    contact    reaction    guarantee    routine    reimbursement    agent    inducing   

Project "Vaprosep" data sheet

The following table provides information about the project.

Coordinator
MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH 

Organization address
address: ASPENHAUSTRASSE 25
city: REUTLINGEN
postcode: 72770
website: www.mediagnost.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mediagnost.de/en/news/summary-of-sme-instrument-phase-i-project-vaprosep-2/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2014
 Funding Scheme SME-1
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2015-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH DE (REUTLINGEN) coordinator 50˙000.00

Map

 Project objective

Sepsis is a complex, systemic and inflammatory host reaction on an infection and with worldwide 1.5 million cases per year a health challenge. There is a strong need for a reliable biomarker like progranulin. Preliminary data prove that progranulin allows a highly sensitive and specific detection of sepsis, a monitoring of infection without time delay, prognosis regarding disease course and a differentiation between the infectious agent inducing sepsis.

Economic advantages of progranulin as biomarker are the reduction of the length of stay in the ICU (500-1000€ / day) and avoidance of unnecessary antibiotic therapy (10-500€ / day). Thus, the hospital can improve patient care and reduce therapeutic costs by a progranulin measurement for 5-10€. A mean incidence rate of 0.094% results in a 12 million euro market in the US and EU. Based on intellectual property this market is available only for Mediagnost. Successfully validated, progranulin measurement will be introduced in third level hospitals in the EU. The subsequent strategic product development includes point of care and multiplex test systems.

Mediagnost already has a technically validated test system for this biomarker available, therefore the overall objectives of this study are the clinical validation of progranulin measurement in sepsis and its implementation in clinical routine. Specifically, in phase I the economic potential of this biomarker is evaluated.

These objectives are addressed during phase I in a feasibility study including market and cost analysis. Key opinion leaders in the EU are interviewed by a structured questionnaire to evaluate scientific solidity and market potential. In direct contact to EU Notified Bodies the best regulatory strategy is evaluated. Further, literature research will complete the picture of the market and reimbursement requirements. Excellent infrastructure and highly qualified scientific and administrative employees guarantee the successful completion of this work.

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The information about "VAPROSEP" are provided by the European Opendata Portal: CORDIS opendata.

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