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MINT SIGNED

Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MINT project word cloud

Explore the words cloud of the MINT project. It provides you a very rough idea of what is the project "MINT" about.

immunogenicity    therapies    receptor    fellowship    zero    cancer    supervisor    multifunctional    human    fundamental    inhibitor    professional    disproportion    probed    tumor    index    biology    monitoring    lethal    unchanged    normalize    interdisciplinary    disturbing    simultaneously    significantly    paid    little    immunocompatible    oxide    nanomaterials    supportive    widening    microenvironment    destiny    nanotheranostics    sectors    researcher    zno    stroma    hedgehog    kinase    transition    excellent    vesicles    biomedical    bridge    zinc    ncs    extracellular    endothelial    drug    metal    clinical    perspectives    coated    malignancies    places    pancreatic    gap    designing    treatment    final    limited    different    benefit    chemotherapeutics    scenario    mint    skills    conventional    therapy    tremendous    vascularity    cells    purpose    evs    outcomes    therapeutic    vascular    ev    efficacy    huge    tools    nanomedicine    frontier    enhanced    leadership    deplete    types    career    doped    nanocrystals    pioneer    expertise   

Project "MINT" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 183˙473.00

Map

 Project objective

Different nanomaterials were developed so far in particular against cancer, paid very little attention to their potential immunogenicity, to their final destiny, as well as to the importance of zero-delivery in unwanted places. Thus, there is still a huge disproportion between the present nanomedicine tools and the clinical requirements. The ambitious purpose of the MINT project is to develop immunocompatible tumor targeted zinc oxide nanocrystals (ZnO-NCs) coated by extracellular vesicles (EVs) with enhanced drug delivery capabilities to cancer cells, by disturbing the supportive tumor microenvironment of pancreatic cancer, one of the most lethal human malignancies. Moreover, ZnO-NCs is doped with transition metal elements to be probed for treatment monitoring. In recent years while several therapeutic advances were implemented in many cancer types, the scenario of pancreatic cancer remains unchanged. The main factor behind the limited efficacy of chemotherapeutics in pancreatic cancer is its complex microenvironment. We propose to deliver Hedgehog pathway inhibitor & vascular endothelial growth factor receptor kinase inhibitor simultaneously through the multifunctional EV-coated doped ZnO-NCs to deplete tumor stroma, normalize tumor vascularity and improve pancreatic cancer therapeutic index. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, experienced in targeted therapy & pancreatic cancer biology, and the supervisor, pioneer in designing nanotheranostics. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in nanotheranostics and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical sectors, bridge the current gap between the conventional therapies and the Frontier research in the field of cancer nanomedicine.

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The information about "MINT" are provided by the European Opendata Portal: CORDIS opendata.

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