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MINT SIGNED

Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer

Total Cost €

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EC-Contrib. €

0

Partnership

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 MINT project word cloud

Explore the words cloud of the MINT project. It provides you a very rough idea of what is the project "MINT" about.

index    researcher    lethal    oxide    conventional    sectors    disproportion    immunocompatible    human    cells    treatment    pancreatic    excellent    therapy    chemotherapeutics    pioneer    huge    monitoring    malignancies    deplete    drug    zno    professional    microenvironment    different    frontier    receptor    inhibitor    fundamental    nanotheranostics    types    coated    ev    zinc    normalize    biomedical    nanomaterials    benefit    probed    paid    endothelial    destiny    efficacy    hedgehog    cancer    leadership    doped    zero    expertise    bridge    fellowship    scenario    multifunctional    disturbing    vascularity    supportive    little    nanomedicine    purpose    significantly    tremendous    supervisor    biology    transition    perspectives    mint    nanocrystals    ncs    simultaneously    enhanced    widening    extracellular    tumor    clinical    evs    skills    vascular    gap    stroma    therapies    metal    kinase    places    unchanged    career    vesicles    tools    outcomes    therapeutic    interdisciplinary    final    immunogenicity    limited    designing   

Project "MINT" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 183˙473.00

Map

 Project objective

Different nanomaterials were developed so far in particular against cancer, paid very little attention to their potential immunogenicity, to their final destiny, as well as to the importance of zero-delivery in unwanted places. Thus, there is still a huge disproportion between the present nanomedicine tools and the clinical requirements. The ambitious purpose of the MINT project is to develop immunocompatible tumor targeted zinc oxide nanocrystals (ZnO-NCs) coated by extracellular vesicles (EVs) with enhanced drug delivery capabilities to cancer cells, by disturbing the supportive tumor microenvironment of pancreatic cancer, one of the most lethal human malignancies. Moreover, ZnO-NCs is doped with transition metal elements to be probed for treatment monitoring. In recent years while several therapeutic advances were implemented in many cancer types, the scenario of pancreatic cancer remains unchanged. The main factor behind the limited efficacy of chemotherapeutics in pancreatic cancer is its complex microenvironment. We propose to deliver Hedgehog pathway inhibitor & vascular endothelial growth factor receptor kinase inhibitor simultaneously through the multifunctional EV-coated doped ZnO-NCs to deplete tumor stroma, normalize tumor vascularity and improve pancreatic cancer therapeutic index. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, experienced in targeted therapy & pancreatic cancer biology, and the supervisor, pioneer in designing nanotheranostics. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in nanotheranostics and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical sectors, bridge the current gap between the conventional therapies and the Frontier research in the field of cancer nanomedicine.

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The information about "MINT" are provided by the European Opendata Portal: CORDIS opendata.

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