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MINT SIGNED

Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MINT project word cloud

Explore the words cloud of the MINT project. It provides you a very rough idea of what is the project "MINT" about.

zero    biology    lethal    pancreatic    tumor    leadership    supportive    vascularity    enhanced    vesicles    ev    professional    doped    huge    bridge    normalize    researcher    zno    interdisciplinary    receptor    drug    multifunctional    career    mint    conventional    nanomedicine    hedgehog    treatment    skills    unchanged    therapies    tremendous    limited    perspectives    monitoring    probed    outcomes    designing    extracellular    pioneer    excellent    nanocrystals    benefit    nanomaterials    transition    tools    immunocompatible    scenario    types    cancer    evs    paid    microenvironment    endothelial    inhibitor    disturbing    purpose    frontier    simultaneously    nanotheranostics    clinical    efficacy    therapeutic    sectors    fundamental    widening    therapy    stroma    destiny    metal    deplete    disproportion    different    vascular    zinc    fellowship    little    human    ncs    expertise    significantly    immunogenicity    biomedical    final    oxide    gap    coated    places    kinase    chemotherapeutics    cells    index    supervisor    malignancies   

Project "MINT" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 183˙473.00

Map

 Project objective

Different nanomaterials were developed so far in particular against cancer, paid very little attention to their potential immunogenicity, to their final destiny, as well as to the importance of zero-delivery in unwanted places. Thus, there is still a huge disproportion between the present nanomedicine tools and the clinical requirements. The ambitious purpose of the MINT project is to develop immunocompatible tumor targeted zinc oxide nanocrystals (ZnO-NCs) coated by extracellular vesicles (EVs) with enhanced drug delivery capabilities to cancer cells, by disturbing the supportive tumor microenvironment of pancreatic cancer, one of the most lethal human malignancies. Moreover, ZnO-NCs is doped with transition metal elements to be probed for treatment monitoring. In recent years while several therapeutic advances were implemented in many cancer types, the scenario of pancreatic cancer remains unchanged. The main factor behind the limited efficacy of chemotherapeutics in pancreatic cancer is its complex microenvironment. We propose to deliver Hedgehog pathway inhibitor & vascular endothelial growth factor receptor kinase inhibitor simultaneously through the multifunctional EV-coated doped ZnO-NCs to deplete tumor stroma, normalize tumor vascularity and improve pancreatic cancer therapeutic index. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, experienced in targeted therapy & pancreatic cancer biology, and the supervisor, pioneer in designing nanotheranostics. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in nanotheranostics and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical sectors, bridge the current gap between the conventional therapies and the Frontier research in the field of cancer nanomedicine.

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The information about "MINT" are provided by the European Opendata Portal: CORDIS opendata.

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