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Myelination SIGNED

Cell biology of myelin wrapping, plasticity and turnover

Total Cost €

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EC-Contrib. €

0

Partnership

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 Myelination project word cloud

Explore the words cloud of the Myelination project. It provides you a very rough idea of what is the project "Myelination" about.

maintenance    basis    axons    cell    myelinated    fill    gap    integrative    wrap    participate    brain    types    hypothesis    actively    give    resolution    tune    impulses    realize    metabolic    molecular    abundant    forces    insulating    unifying    metabolically    off    continuous    nervous    drive    fuelled    participating    turnover    structural    sheath    regular    biology    pursue    shift    arises    remodelling    myelin    plasticity    limited    generate    laid    central    axon    obtain    extension    modulating    model    active    regarded    nerve    proteomics    myelination    biochemistry    adulthood    tightly    stimuli    combination    multidisciplinary    segments    stack    formed    paradigm    packed    period    networks    genetics    imaging    oligodendrocytes    fine    regulated    fragments    degradation    successful    appears    membrane    natal    plan    velocity    pinch    mechanistic    purely    synchronicity    adult    previously    underlying    microglia    mechanisms    spaced    plasma    post    spirally    inert    neuronal    membranes    innovation   

Project "Myelination" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN 

Organization address
address: Arcisstrasse 21
city: MUENCHEN
postcode: 80333
website: www.tu-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙872˙500 €
 EC max contribution 1˙872˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙392˙195.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 480˙304.00

Map

 Project objective

The myelin sheath is a plasma membrane extension that is laid down in regular spaced segments along axons of the nervous system. In the central nervous system it is formed by oligodendrocytes that spirally wrap their plasma membrane around axons to generate a highly abundant, tightly packed stack of membranes with unique structural properties. Previously, myelin has been regarded as an inert and purely insulating membrane, but it now appears that myelin is metabolically active, providing metabolic support to the underlying axon and participating in information processing by modulating velocity and synchronicity of nerve impulses in neuronal networks. In addition, myelination is not limited to the period of early post-natal development, but continuous into adulthood where it appears to be regulated by neuronal stimuli. This paradigm shift should be fuelled by new knowledge about myelin biology. Here, we plan to fill this gap by addressing the molecular basis of myelin growth, plasticity and remodelling. We will determine the factors that determine whether and to what extent an axon will be myelinated or not, the forces that drive myelin around the axon, the structural basis of myelin plasticity and the mechanisms of myelin turnover in the adult. We will test the hypothesis that microglia actively participate in myelin turnover by taking up myelin fragments that pinch off from the myelin sheath. To realize these aims we plan to pursue an integrative and multidisciplinary approach by bringing together genetics, biochemistry, proteomics and imaging in various model systems. The innovation arises from the combination of high-resolution imaging with molecular approaches in different cell types to obtain a unifying mechanistic understanding of myelin formation, maintenance and degradation. If successful, the project would not only explain how myelin is generated during brain development, but also give insight into how myelin plasticity could fine-tune neuronal networks.

 Publications

year authors and title journal last update
List of publications.
2016 Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L Edinger, Steffen Jung, Moritz J Rossner, Mikael Simons
Age-related myelin degradation burdens the clearance function of microglia during aging
published pages: 995-998, ISSN: 1097-6256, DOI: 10.1038/nn.4325
Nature Neuroscience 19/8 2019-05-31
2018 Ludovico Cantuti-Castelvetri, Dirk Fitzner, Mar Bosch-Queralt, Marie-Theres Weil, Minhui Su, Paromita Sen, Torben Ruhwedel, Miso Mitkovski, George Trendelenburg, Dieter Lütjohann, Wiebke Möbius, Mikael Simons
Defective cholesterol clearance limits remyelination in the aged central nervous system
published pages: eaan4183, ISSN: 0036-8075, DOI: 10.1126/science.aan4183
Science 2019-05-31
2017 Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin
published pages: 314-323, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.12.053
Cell Reports 18/2 2019-05-31
2017 Maryam K. Fard, Franziska van der Meer, Paula Sánchez, Ludovico Cantuti-Castelvetri, Sunit Mandad, Sarah Jäkel, Eugenio F. Fornasiero, Sebastian Schmitt, Marc Ehrlich, Laura Starost, Tanja Kuhlmann, Christina Sergiou, Verena Schultz, Claudia Wrzos, Wolfgang Brück, Henning Urlaub, Leda Dimou, Christine Stadelmann, Mikael Simons
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
published pages: eaam7816, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aam7816
Science Translational Medicine 9/419 2019-05-31
2016 Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
published pages: 314-322, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.06.008
Cell Reports 16/2 2019-05-31

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