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MultiScaleNeurovasc SIGNED

Quantifying the structure-function of the neurovascular interface: from micro-circuits to large-scale functional organization

Total Cost €

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EC-Contrib. €

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Partnership

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 MultiScaleNeurovasc project word cloud

Explore the words cloud of the MultiScaleNeurovasc project. It provides you a very rough idea of what is the project "MultiScaleNeurovasc" about.

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Project "MultiScaleNeurovasc" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Project website http://www.pblab.tau.ac.il
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

Map

 Project objective

Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions. In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia. This coupling between neuronal and vascular activtuy underpins the mechanism enabling fMRI to map neuronal activity based on vascular dynamics; further, malfunction of the cellular players involved in coupling is now considered to play a key role in otherwise classically defined neurodegenerative diseases. We lack a concise description of the inner workings of this mechanism and a thorough quantitative description of the neuro-gila-vascular interface; issues that are best addressed by an investigation into the cellular mechanisms, the temporal dynamics and multi-scale spatial organization governing neurovascular coupling. My long-term goal is to provide a unified theory to encapsulate our knowledge on neurovascular coupling. Here, I hypothesize that functional hyperaemia results from the constant integration of vasoactive cues with region-dependent coupling emerging from different neuro-glia-vascular microcircuits, nuances in afferent wiring into vascular contractile elements and/or neuronal activity patterns. I will test this hypothesis with a multi-faceted correlative approach combining: two-photon awake imaging of cellular and vascular dynamics to obtain physiological data unaffected by anaesthetics; super-resolution structural imaging of intact volumes to map the fine details of micro-circuit structure; array-tomography to map in situ the neurovascular signalling machinery and novel optogenic tools to manipulate several of its specific components. I expect to offer a revolutionary mechanistic insight into one of the most basic and fundamental physiological processes behind the structure and function of the brain.

 Publications

year authors and title journal last update
List of publications.
2017 Kâmil Uludağ, Pablo Blinder
Linking brain vascular physiology to hemodynamic response in ultra-high field MRI
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.02.063
NeuroImage 2020-03-17
2018 Matthew D. Adams, Aaron T. Winder, Pablo Blinder, Patrick J. Drew
The pial vasculature of the mouse develops according to a sensory-independent program
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27910-3
Scientific Reports 8/1 2020-03-17
2017 Alan Urban, Lior Golgher, Clément Brunner, Amos Gdalyahu, Hagai Har-Gil, David Kain, Gabriel Montaldo, Laura Sironi, Pablo Blinder
Understanding the neurovascular unit at multiple scales: Advantages and limitations of multi-photon and functional ultrasound imaging
published pages: 73-100, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.018
Advanced Drug Delivery Reviews 119 2020-03-17

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