Explore the words cloud of the MultiScaleNeurovasc project. It provides you a very rough idea of what is the project "MultiScaleNeurovasc" about.
The following table provides information about the project.
TEL AVIV UNIVERSITY
|Coordinator Country||Israel [IL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2021-05-31|
Take a look of project's partnership.
|1||TEL AVIV UNIVERSITY||IL (TEL AVIV)||coordinator||1˙500˙000.00|
Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions. In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia. This coupling between neuronal and vascular activtuy underpins the mechanism enabling fMRI to map neuronal activity based on vascular dynamics; further, malfunction of the cellular players involved in coupling is now considered to play a key role in otherwise classically defined neurodegenerative diseases. We lack a concise description of the inner workings of this mechanism and a thorough quantitative description of the neuro-gila-vascular interface; issues that are best addressed by an investigation into the cellular mechanisms, the temporal dynamics and multi-scale spatial organization governing neurovascular coupling. My long-term goal is to provide a unified theory to encapsulate our knowledge on neurovascular coupling. Here, I hypothesize that functional hyperaemia results from the constant integration of vasoactive cues with region-dependent coupling emerging from different neuro-glia-vascular microcircuits, nuances in afferent wiring into vascular contractile elements and/or neuronal activity patterns. I will test this hypothesis with a multi-faceted correlative approach combining: two-photon awake imaging of cellular and vascular dynamics to obtain physiological data unaffected by anaesthetics; super-resolution structural imaging of intact volumes to map the fine details of micro-circuit structure; array-tomography to map in situ the neurovascular signalling machinery and novel optogenic tools to manipulate several of its specific components. I expect to offer a revolutionary mechanistic insight into one of the most basic and fundamental physiological processes behind the structure and function of the brain.
|year||authors and title||journal||last update|
KÃ¢mil UludaÄŸ, Pablo Blinder
Linking brain vascular physiology to hemodynamic response in ultra-high field MRI
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.02.063
Matthew D. Adams, Aaron T. Winder, Pablo Blinder, Patrick J. Drew
The pial vasculature of the mouse develops according to a sensory-independent program
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27910-3
|Scientific Reports 8/1||2020-03-17|
Alan Urban, Lior Golgher, ClÃ©ment Brunner, Amos Gdalyahu, Hagai Har-Gil, David Kain, Gabriel Montaldo, Laura Sironi, Pablo Blinder
Understanding the neurovascular unit at multiple scales: Advantages and limitations of multi-photon and functional ultrasound imaging
published pages: 73-100, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.018
|Advanced Drug Delivery Reviews 119||2020-03-17|
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