Opendata, web and dolomites

MultiScaleNeurovasc SIGNED

Quantifying the structure-function of the neurovascular interface: from micro-circuits to large-scale functional organization

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MultiScaleNeurovasc project word cloud

Explore the words cloud of the MultiScaleNeurovasc project. It provides you a very rough idea of what is the project "MultiScaleNeurovasc" about.

coupling    faceted    fine    neurodegenerative    unified    neuro    nuances    extremely    optogenic    data    afferent    phenomenon    manipulate    lack    interface    active    theory    vascular    mechanisms    description    array    nutrients    quantitative    cues    play    mechanistic    temporal    situ    microcircuits    thorough    dynamics    brain    anaesthetics    concise    super    calling    obtain    details    fundamental    vasoactive    demand    integration    basic    diseases    constant    patterns    hypothesize    wiring    organization    circuit    photon    micro    otherwise    encapsulate    dependent    gila    regions    region    flow    hypothesis    metabolic    volumes    inner    area    revolutionary    tools    neurovascular    signalling    mechanism    supply    budget    awake    components    structural    blood    underpins    cellular    imaging    neuronal    spatial    contractile    combining    functional    fmri    intact    classically    machinery    malfunction    activtuy    glia    workings    unaffected    computations    physiological    players    tomography    resolution    investigation    function    governing    structure    hyperaemia    map    limited    correlative   

Project "MultiScaleNeurovasc" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.pblab.tau.ac.il
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

Map

 Project objective

Neuronal computations in the brain require a high metabolic budget yet the brain has extremely limited resources; calling for an on-demand, robust supply system to deliver nutrients to active regions. In most cases, neuronal activity results in an increase in blood flow to the active area, a phenomenon called functional hyperaemia. This coupling between neuronal and vascular activtuy underpins the mechanism enabling fMRI to map neuronal activity based on vascular dynamics; further, malfunction of the cellular players involved in coupling is now considered to play a key role in otherwise classically defined neurodegenerative diseases. We lack a concise description of the inner workings of this mechanism and a thorough quantitative description of the neuro-gila-vascular interface; issues that are best addressed by an investigation into the cellular mechanisms, the temporal dynamics and multi-scale spatial organization governing neurovascular coupling. My long-term goal is to provide a unified theory to encapsulate our knowledge on neurovascular coupling. Here, I hypothesize that functional hyperaemia results from the constant integration of vasoactive cues with region-dependent coupling emerging from different neuro-glia-vascular microcircuits, nuances in afferent wiring into vascular contractile elements and/or neuronal activity patterns. I will test this hypothesis with a multi-faceted correlative approach combining: two-photon awake imaging of cellular and vascular dynamics to obtain physiological data unaffected by anaesthetics; super-resolution structural imaging of intact volumes to map the fine details of micro-circuit structure; array-tomography to map in situ the neurovascular signalling machinery and novel optogenic tools to manipulate several of its specific components. I expect to offer a revolutionary mechanistic insight into one of the most basic and fundamental physiological processes behind the structure and function of the brain.

 Publications

year authors and title journal last update
List of publications.
2017 Kâmil Uludağ, Pablo Blinder
Linking brain vascular physiology to hemodynamic response in ultra-high field MRI
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.02.063
NeuroImage 2020-03-17
2018 Matthew D. Adams, Aaron T. Winder, Pablo Blinder, Patrick J. Drew
The pial vasculature of the mouse develops according to a sensory-independent program
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27910-3
Scientific Reports 8/1 2020-03-17
2017 Alan Urban, Lior Golgher, Clément Brunner, Amos Gdalyahu, Hagai Har-Gil, David Kain, Gabriel Montaldo, Laura Sironi, Pablo Blinder
Understanding the neurovascular unit at multiple scales: Advantages and limitations of multi-photon and functional ultrasound imaging
published pages: 73-100, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.018
Advanced Drug Delivery Reviews 119 2020-03-17

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MULTISCALENEUROVASC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MULTISCALENEUROVASC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DistMaP (2019)

Distributed and Massively Parallel Graph Algorithms

Read More  

MADEFUN (2019)

Regulation of Brain Macrophage Development and Function

Read More  

WordMeasures (2020)

Word Measures in Groups and Random Cayley Graphs

Read More