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SVNanoVax SIGNED

Structural Vaccinology in the design of bionanoparticles with multi-copy antigen display for vaccines with enhanced efficacy

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 SVNanoVax project word cloud

Explore the words cloud of the SVNanoVax project. It provides you a very rough idea of what is the project "SVNanoVax" about.

lives    sepsis    safety    suitable    mapping    stably    encompassing    disease    opportunity    variability    2nd    secondly    self    antigens    generate    map    prepared    pioneered    bexsero    bachmann    innovative    antibodies    save    structure    nanobiology    issue    escape    pace    scarselli    aid    enhanced    functional    bionanoparticles    antigen    meningococcal    reducing    combine    broadly    career    nada    epitopes    protective    vaccines    immunogenicity    generation    pathogens    monoclonal    candidates    structural    bnp    probability    2012    arrays    vaccine    display    safe    copy    host    epitope    optimized    invasive    potentiate    bactericidal    promises    quality    malito    bionanoparticle    overcome    expertise    fhbp    assembling    1st    protein    approved    2014    coverage    vaccinology    sequence    million    bnps    ryan    3d    ordered    combines    immunogenic    delany    offers    menb    neisseria    2013    protect    2011    infectious    termed    firstly    breadth    humans    serogroup    structures    meningitidis    diseases    displaying    2010   

Project "SVNanoVax" data sheet

The following table provides information about the project.

Coordinator		 GLAXOSMITHKLINE VACCINES SRL 

Organization address
address: VIA FIORENTINA 1
city: SIENA
postcode: 53100
website: www.novartis.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-06-15   to  2017-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GLAXOSMITHKLINE VACCINES SRL IT (SIENA) coordinator 168˙277.00

Map

 Project objective

Vaccines are the most effective way to protect humans from infectious disease and may save over 2 million lives per year (Delany, 2013). A key issue for future vaccines is how to improve immunogenicity without reducing safety (Bachmann, 2010). Another challenge is that high antigen sequence variability enables pathogens to escape the host response. To overcome these challenges, this proposal combines Structural Vaccinology and bionanoparticle (BNP) design, to generate novel self-assembling BNPs with multi-copy antigen display for the development of safe vaccine antigens with enhanced immunogenicity and breadth of coverage.

We will generate antigen-BNPs for a 2nd generation vaccine against Neisseria meningitidis serogroup B (MenB), a major cause of sepsis and invasive disease (Pace, 2012). This research may also potentiate antigen-BNP technology suitable for other vaccines. Firstly, we will use functional (bactericidal) monoclonal antibodies to map the most protective epitopes on the 3D structures of two key MenB antigens, fHbp and NadA, which contribute strongly to our recently-approved 1st generation MenB vaccine, Bexsero (O’Ryan, 2014). To aid this, we have developed wide expertise in structure-focused epitope mapping (Malito, 2013). Secondly, we will design optimized antigens stably displaying the best epitopes, an approach that we have pioneered and termed ‘Structural Vaccinology’ (Scarselli, 2011). Finally, self-assembling protein bionanoparticles displaying ordered arrays of the optimized antigens will be prepared, in order to generate novel highly-immunogenic, broadly-protective MenB vaccine candidates.

The proposal offers an exciting career development opportunity encompassing novel high-quality research to combine and deliver the promises of Structural Vaccinology and nanobiology, with a high probability of success to generate innovative new vaccine antigens for products to protect humans against meningococcal and other infectious diseases.

 Publications

year authors and title journal last update
List of publications.
2016 Jacinto López-Sagaseta, Enrico Malito, Rino Rappuoli, Matthew J. Bottomley
Self-assembling protein nanoparticles in the design of vaccines
published pages: 58-68, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2015.11.001 		Computational and Structural Biotechnology Journal 14 2019-06-18

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