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Dementia

DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

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 Dementia project word cloud

Explore the words cloud of the Dementia project. It provides you a very rough idea of what is the project "Dementia" about.

unparalleled    neurodegenerative    delta    progressive    decline    transgenic    identification    damage    offers    opening    plaques    medication    worldwide    quantitative    qol    profiles    beta    despite    fail    mouse    amyloid    connection    similarities    50    unprecedented    rna    million    erc    prominent    indicating    valid    resource    classes    care    transition    unmet    primary    generating    spectacularly    combating    model    health    represented    progression    instrumental    final    lt    magnitude    biomarkers    overexpressing    companies    aggregates    parallels    dramatic    mice    seriously    ercc1    realistic    relies    perspectives    bona    ad    dna    proteins    interventions    alzheimer    poc    characterization    economical    preclinical    age    expression    tangles    human    context    mainly    mutants    provides    deficient    repair    socio    genome       complete    syndromes    intervention    disease    striking    patients    cognitive    huge    monitoring    medical    poorly    prevention    brain    discovered    therapy    neurodegeneration    disclosed    nutritional    compartments    fide    people    delay    mutant    requirement    protein    aging    models    altered    pharmaceutical    disorders    tau   

Project "Dementia" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 150˙000.00

Map

 Project objective

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models. Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for prevention and/or therapy. This proposal addresses a huge unmet medical need worldwide, which seriously affects QoL, challenges health care systems, and offers unprecedented socio-economical opportunities.

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The information about "DEMENTIA" are provided by the European Opendata Portal: CORDIS opendata.

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