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Dementia

DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Dementia project word cloud

Explore the words cloud of the Dementia project. It provides you a very rough idea of what is the project "Dementia" about.

realistic    classes    spectacularly    provides    transgenic    nutritional    neurodegeneration    unprecedented    alzheimer    proteins    model    profiles    identification    amyloid    cognitive    tangles    rna    complete    represented    combating    fail    requirement    discovered    health    genome    damage    parallels    economical    despite    bona    beta    quantitative    ad    prevention    mouse    final    therapy    lt    mainly    huge    similarities    progression    companies    dramatic    connection    deficient    striking    million    protein    models    relies    altered    worldwide    context    tau    generating    unmet    aging    magnitude    opening    biomarkers    interventions    qol    erc    delay    human    primary    disorders    fide    pharmaceutical    disclosed    mutant    preclinical    monitoring    mutants    brain    poorly    socio    intervention    dna    people    syndromes    offers    transition    plaques    repair    disease    delta    neurodegenerative       indicating    overexpressing    care    valid    expression    seriously    age    ercc1    progressive    aggregates    perspectives    medical    resource    compartments    prominent    poc    medication    decline    mice    instrumental    50    unparalleled    patients    characterization   

Project "Dementia" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 150˙000.00

Map

 Project objective

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models. Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for prevention and/or therapy. This proposal addresses a huge unmet medical need worldwide, which seriously affects QoL, challenges health care systems, and offers unprecedented socio-economical opportunities.

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The information about "DEMENTIA" are provided by the European Opendata Portal: CORDIS opendata.

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