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Dementia

DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

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 Dementia project word cloud

Explore the words cloud of the Dementia project. It provides you a very rough idea of what is the project "Dementia" about.

combating    therapy    opening    overexpressing    beta    prevention    tangles    tau    discovered    fide    patients    expression    50    offers    dramatic    unparalleled    interventions    preclinical    indicating    monitoring    economical    mice    quantitative    mutants    brain    care    medical    generating    plaques    mainly    progression    magnitude    primary    cognitive    striking    transition    mutant    damage    repair    delay    requirement    million    amyloid    connection    relies    decline    compartments    transgenic    proteins    realistic    aggregates    seriously    ercc1    disease    models    companies    profiles    medication    perspectives    progressive    syndromes    alzheimer    huge    biomarkers    complete    unmet    rna    prominent    final    similarities    age    aging    socio    bona    disorders    ad    altered    valid    context    instrumental    represented    characterization    parallels    despite    intervention    protein    disclosed    worldwide    unprecedented    people    pharmaceutical    neurodegenerative    model    spectacularly    provides    poorly    lt    fail    nutritional    mouse    qol    erc    identification    delta    dna    human    resource    genome    classes    neurodegeneration    poc    deficient    health      

Project "Dementia" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 150˙000.00

Map

 Project objective

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models. Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for prevention and/or therapy. This proposal addresses a huge unmet medical need worldwide, which seriously affects QoL, challenges health care systems, and offers unprecedented socio-economical opportunities.

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The information about "DEMENTIA" are provided by the European Opendata Portal: CORDIS opendata.

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