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Dementia

DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics

Total Cost €

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EC-Contrib. €

0

Partnership

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 Dementia project word cloud

Explore the words cloud of the Dementia project. It provides you a very rough idea of what is the project "Dementia" about.

compartments    nutritional    genome    mice    discovered    perspectives    damage    disease    resource    instrumental    neurodegenerative    mutants    represented    context    seriously    quantitative    delay    protein    classes    profiles    relies    huge    brain    biomarkers    generating    characterization    primary    beta    interventions    lt    transgenic    requirement    pharmaceutical    opening    repair    progressive    ercc1    monitoring    rna    worldwide    unprecedented    50    age    fail    decline    poorly    health    care    model    aging    socio    poc    magnitude    identification    striking    spectacularly    overexpressing    proteins    progression    unparalleled    erc    deficient    offers    valid    connection    economical    realistic    disorders    prominent    syndromes    final    ad    disclosed    indicating    amyloid    unmet    plaques    tau    neurodegeneration    aggregates    provides    medical    mutant    human    models    million       patients    transition    parallels    altered    preclinical    qol    bona    combating    mainly    fide    intervention    people    therapy    despite    mouse    alzheimer    dramatic    dna    similarities    companies    medication    prevention    tangles    complete    cognitive    expression    delta   

Project "Dementia" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2016-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 150˙000.00

Map

 Project objective

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models. Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for prevention and/or therapy. This proposal addresses a huge unmet medical need worldwide, which seriously affects QoL, challenges health care systems, and offers unprecedented socio-economical opportunities.

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The information about "DEMENTIA" are provided by the European Opendata Portal: CORDIS opendata.

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