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Water as cosubstrate for biocatalytic redox reactions

Total Cost €


EC-Contrib. €






Project "BioAqua" data sheet

The following table provides information about the project.


Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙998˙020 €
 EC max contribution 1˙998˙020 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 1˙998˙020.00


 Project objective

The research proposed in BioAqua aims at breaking new ground in the area of catalysis by enabling water-driven biocatalytic redox reactions.

Oxidoreductases are a class of enzymes with a very high potential for preparative organic synthesis, which is why they are increasingly used also on industrial scale. The current state-of-the-art, however, utilises valuable high-energy cosubstrates (such as glucose and alcohols) to promote oxidoreductases. Thereby valuable (and edible) building blocks are wasted as sacrificial electron donors which will have significant ethical (food for chemistry), economic and environmental consequences once redox biocatalysis is applied at scale. I envision utilizing water as sacrificial electron donor. Hence, a simple and abundant cosubstrate will be used instead of the valuable cosubstrates mentioned above. This will be a completely new approach in (bio)catalysis. However, activating water for this purpose water is extremely difficult due to its kinetic and thermodynamic inertness. To solve this problem, I propose using visible light as external energy source and advanced chemical catalysts to facilitate water oxidation. The electrons liberated in this process will be made available (for the first time) to promote oxidoreductases-catalysed transformations.

BioAqua represents an entirely new paradigm in catalysis as I will bridge the gap between photocatalysis and biocatalysis enabling cleaner and more efficient reaction schemes.


year authors and title journal last update
List of publications.
2019 Milja Pesic, Sébastien Jean-Paul Willot, Elena Fernández-Fueyo, Florian Tieves, Miguel Alcalde, Frank Hollmann
Multienzymatic in situ hydrogen peroxide generation cascade for peroxygenase-catalysed oxyfunctionalisation reactions
published pages: 101-104, ISSN: 0939-5075, DOI: 10.1515/znc-2018-0137
Zeitschrift für Naturforschung C 74/3-4 2020-02-18
2020 Hee-Jeong Cha, Se-Yeun Hwang, Da-Som Lee, Ravi Kumar Akula, Yong-Uk Kwon, Moritz Voß, Eva Schuiten, Uwe Bornscheuer, Frank Hollmann, Deok-Kun Oh, Jin-Byung Park
Whole-Cell Photoenzymatic Cascades to Synthesize Long Chain Aliphatic Amines and Esters from Renewable Fatty Acids
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201915108
Angewandte Chemie International Edition 2020-02-18
2019 Florian Tieves, Fabio Tonin, Elena Fernández-Fueyo, John M. Robbins, Bettina Bommarius, Andreas S. Bommarius, Miguel Alcalde, Frank Hollmann
Energising the E-factor: The E+-factor
published pages: 1311-1314, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.01.065
Tetrahedron 75/10 2020-02-18
2019 Florian Tieves, Sébastien Jean-Paul Willot, Morten Martinus Cornelis Harald van Schie, Marine Charlène Renée Rauch, Sabry Hamdy Hamed Younes, Wuyuan Zhang, JiaJia Dong, Patricia Gomez de Santos, John Mick Robbins, Bettina Bommarius, Miguel Alcalde, Andreas Sebastian Bommarius, Frank Hollmann
Formate Oxidase (FOx) from Aspergillus oryzae : One Catalyst Enables Diverse H 2 O 2 -Dependent Biocatalytic Oxidation Reactions
published pages: 7873-7877, ISSN: 1433-7851, DOI: 10.1002/anie.201902380
Angewandte Chemie International Edition 58/23 2020-02-18
2018 Frank Hollmann, Selin Kara, Diederik J. Opperman, Yonghua Wang
Biocatalytic synthesis of lactones and lactams
published pages: 3601-3610, ISSN: 1861-4728, DOI: 10.1002/asia.201801180
Chemistry - An Asian Journal 13/23 2020-02-18
2018 Georg T. Höfler, Elena Fernández-Fueyo, Milja Pesic, Sabry H. Younes, Eun-Gyu Choi, Yong H. Kim, Vlada B. Urlacher, Isabel W. C. E. Arends, Frank Hollmann
A Photoenzymatic NADH Regeneration System
published pages: 2344-2347, ISSN: 1439-4227, DOI: 10.1002/cbic.201800530
ChemBioChem 19/22 2020-02-18
2019 Jie Zhang, Fabio Tonin, Wuyuan Zhang, Peter-Leon Hagedoorn, Lloyd Mallée, Frank Hollmann
‘Clean’ hydrolase reactions using commercial washing powder
published pages: 24039-24042, ISSN: 2046-2069, DOI: 10.1039/c9ra05828a
RSC Advances 9/42 2020-02-18
2019 Jenő Gacs, Wuyuan Zhang, Tanja Knaus, Francesco G. Mutti, Isabel W.C.E. Arends, Frank Hollmann
A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines
published pages: 305, ISSN: 2073-4344, DOI: 10.3390/catal9040305
Catalysts 9/4 2020-02-18
2015 Pablo Domínguez de María, Frank Hollmann
On the (Un)greenness of Biocatalysis: Some Challenging Figures and Some Promising Options
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2015.01257
Frontiers in Microbiology 6 2020-02-18
2019 Sabry H. H. Younes, Florian Tieves, Dongming Lan, Yonghua Wang, Philipp Süss, Henrike Brundiek, Ron Wever, Frank Hollmann
Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols
published pages: 97-101, ISSN: 1864-5631, DOI: 10.1002/cssc.201902240
ChemSusChem 13/1 2020-02-18
2020 Georg T. Höfler, Andrada But, Sabry H. H. Younes, Ron Wever, Caroline E. Paul, Isabel W. C. E. Arends, Frank Hollmann
Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
published pages: , ISSN: 2168-0485, DOI: 10.1021/acssuschemeng.9b07494
ACS Sustainable Chemistry & Engineering 2020-02-18
2019 Yunjian Ma, Yongru Li, Shahid Ali, Peilin Li, Wuyuan Zhang, Marine C. R. Rauch, Sébastien J.‐P. Willot, Doris Ribitsch, Young Hae Choi, Miguel Alcalde, Frank Hollmann, Yonghua Wang
Natural Deep Eutectic Solvents as Performance Additives for Peroxygenase Catalysis
published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201901842
ChemCatChem 2020-02-18
2019 Willot, Tieves, Girhard, Urlacher, Hollmann, de Gonzalo
P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules
published pages: 567, ISSN: 2073-4344, DOI: 10.3390/catal9070567
Catalysts 9/7 2020-02-18
2020 M.C.R. Rauch, M.M.E. Huijbers, M. Pabst, C.E. Paul, M. Pešić, I.W.C.E. Arends, F. Hollmann
Photochemical regeneration of flavoenzymes – An Old Yellow Enzyme case-study
published pages: 140303, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2019.140303
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868/1 2020-02-18
2019 Yunjian Ma, Peilin Li, Yongru Li, Sébastien J.‐P. Willot, Wuyuan Zhang, Doris Ribitsch, Young Hae Choi, Robert Verpoorte, Tianyu Zhang, Frank Hollmann, Yonghua Wang
Natural Deep Eutectic Solvents as Multifunctional Media for the Valorization of Agricultural Wastes
published pages: 1310-1315, ISSN: 1864-5631, DOI: 10.1002/cssc.201900043
ChemSusChem 12/7 2020-02-18
2019 Wuyuan Zhang, Elena Fernandez Fueyo, Frank Hollmann, Laura Leemans Martin, Milja Pesic, Rainer Wardenga, Matthias Höhne, Sandy Schmidt
Combining Photo-Organo Redox- and Enzyme Catalysis Facilitates Asymmetric C-H Bond Functionalization
published pages: 80-84, ISSN: 1434-193X, DOI: 10.1002/ejoc.201801692
European Journal of Organic Chemistry 2019/1 2020-02-18
2019 B. O. Burek, S. Bormann, F. Hollmann, J. Z. Bloh, D. Holtmann
Hydrogen peroxide driven biocatalysis
published pages: 3232-3249, ISSN: 1463-9262, DOI: 10.1039/c9gc00633h
Green Chemistry 21/12 2020-02-18
2020 Yongru Li, Yunjian Ma, Peilin Li, Xizhen Zhang, Doris Ribitsch, Miguel Alcalde, Frank Hollmann, Yonghua Wang
Enantioselective Sulfoxidation of Thioanisole by Cascading a Choline Oxidase and a Peroxygenase in the Presence of Natural Deep Eutectic Solvents
published pages: 254-257, ISSN: 2192-6506, DOI: 10.1002/cplu.201900751
ChemPlusChem 85/1 2020-02-18
2019 Musa M. Musa, Frank Hollmann, Francesco G. Mutti
Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods
published pages: 5487-5503, ISSN: 2044-4753, DOI: 10.1039/c9cy01539f
Catalysis Science & Technology 9/20 2020-02-18
2019 Laia Josa-Culleré, Antti Lahdenperä, Aubert Ribaucourt, Georg Höfler, Serena Gargiulo, Yuan-Yang Liu, Jian-He Xu, Jennifer Cassidy, Francesca Paradisi, Diederik Opperman, Frank Hollmann, Caroline Paul
Synthetic Biomimetic Coenzymes and Alcohol Dehydrogenases for Asymmetric Catalysis
published pages: 207, ISSN: 2073-4344, DOI: 10.3390/catal9030207
Catalysts 9/3 2020-02-18
2017 Milja Pesic, Elena Fernández-Fueyo, Frank Hollmann
Characterization of the Old Yellow Enzyme Homolog from Bacillus subtilis (YqjM)
published pages: 3866-3871, ISSN: 2365-6549, DOI: 10.1002/slct.201700724
ChemistrySelect 2/13 2019-06-06
2018 Wuyuan Zhang, Frank Hollmann
Nonconventional regeneration of redox enzymes – a practical approach for organic synthesis?
published pages: 7281-7289, ISSN: 1359-7345, DOI: 10.1039/C8CC02219D
Chemical Communications 54/53 2019-06-06
2016 Dirk Holtmann, Frank Hollmann
The Oxygen Dilemma: A Severe Challenge for the Application of Monooxygenases?
published pages: 1391-1398, ISSN: 1439-4227, DOI: 10.1002/cbic.201600176
ChemBioChem 17/15 2019-06-06
2017 Wuyuan Zhang, Bastien O. Burek, Elena Fernández-Fueyo, Miguel Alcalde, Jonathan Z. Bloh, Frank Hollmann
Selective Activation of C−H Bonds in a Cascade Process Combining Photochemistry and Biocatalysis
published pages: 15451-15455, ISSN: 1433-7851, DOI: 10.1002/anie.201708668
Angewandte Chemie International Edition 56/48 2019-06-06
2018 JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline E. Paul, Milja Pesic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang
Biocatalytic Oxidation Reactions: A Chemist\'s Perspective
published pages: 9238-9261, ISSN: 1433-7851, DOI: 10.1002/anie.201800343
Angewandte Chemie International Edition 57/30 2019-06-06
2016 Elena Fernández-Fueyo, Yan Ni, Alvaro Gomez Baraibar, Miguel Alcalde, Lukas M. van Langen, Frank Hollmann
Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media
published pages: 347-352, ISSN: 1381-1177, DOI: 10.1016/j.molcatb.2016.09.013
Journal of Molecular Catalysis B: Enzymatic 134 2019-06-06
2017 Wuyuan Zhang, Jenő Gacs, Isabel W. C. E. Arends, Frank Hollmann
Selective Photooxidation Reactions using Water-Soluble Anthraquinone Photocatalysts
published pages: 3821-3826, ISSN: 1867-3880, DOI: 10.1002/cctc.201700779
ChemCatChem 9/20 2019-06-06
2017 Yonghua Wang, Dongming Lan, Rabia Durrani, Frank Hollmann
Peroxygenases en route to becoming dream catalysts. What are the opportunities and challenges?
published pages: 1-9, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2016.10.007
Current Opinion in Chemical Biology 37 2019-06-06
2017 M. Rauch, S. Schmidt, I. W. C. E. Arends, K. Oppelt, S. Kara, F. Hollmann
Photobiocatalytic alcohol oxidation using LED light sources
published pages: 376-379, ISSN: 1463-9262, DOI: 10.1039/C6GC02008A
Green Chem. 19/2 2019-06-06
2017 Wuyuan Zhang, Anna Bariotaki, Ioulia Smonou, Frank Hollmann
Visible-light-driven photooxidation of alcohols using surface-doped graphitic carbon nitride
published pages: 2096-2100, ISSN: 1463-9262, DOI: 10.1039/c7gc00539c
Green Chemistry 19/9 2019-06-06
2015 Yan Ni, Frank Hollmann
Artificial Photosynthesis: Hybrid Systems
published pages: , ISSN: , DOI: 10.1007/10_2015_5010
Advances in Biochemical Engineering/Biotechnology 2019-06-06
2017 Sabry Younes, Yan Ni, Sandy Schmidt, Wolfgang Kroutil, Frank Hollmann
Alcohol dehydrogenases catalyze the reduction of thioesters
published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201700165
ChemCatChem 2019-06-06
2018 Wuyuan Zhang, Elena Fernández-Fueyo, Yan Ni, Morten van Schie, Jenö Gacs, Rokus Renirie, Ron Wever, Francesco G. Mutti, Dörte Rother, Miguel Alcalde, Frank Hollmann
Selective aerobic oxidation reactions using a combination of photocatalytic water oxidation and enzymatic oxyfunctionalizations
published pages: 55-62, ISSN: 2520-1158, DOI: 10.1038/s41929-017-0001-5
Nature Catalysis 1/1 2019-06-06

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