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Understanding the role of lysosomes in the intercellular TNT-mediated spreading of α-synuclein and the impact of lysosomal dysfunction

Total Cost €


EC-Contrib. €






 LySyT project word cloud

Explore the words cloud of the LySyT project. It provides you a very rough idea of what is the project "LySyT" about.

accumulates    insights    implications    suggested    prion    inherited    transport    nds    fibrils    brain    cytosolic    unravel    showed    materials    metabolic    combining    acceptor    skills    neurodegenerative    zurzolo    valuable    causes    hallmark    pd    loaded    degraded    severe    lysosomes    escape    microtubules    nanotubes    lysosome    inside    shed    understand    death    deep    disorders    defective    dysfunction    caused    spread    group    lab    receiving    linked    physiopathology    neurodegeneration    host    perspective    disease    light    actin    thin    generally    cells    aggregates    correlation    etiopathogenesis    tnts    membrane    syn    nd    diseases    fate    function    lysosomal    monomers    aggregation    neuronal    regions    storage    progression    synuclein    decades    combat    misfolded    spreading    protein    trait    accumulation    intercellular    forms    move    transferred    lsds    tunneling    over    shared    soluble    induce    incurable    expertise    demonstrated    mediating    cargos    last    protrusions    global    enzyme    few    rare    pathogenesis    alpha    mechanism    became    pathology    parkinson   

Project "LySyT" data sheet

The following table provides information about the project.


Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-12-01   to  2022-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 184˙707.00


 Project objective

Over the last few decades, neurodegenerative diseases (NDs) became one of the top 10 global causes of death. The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several NDs. Misfolded alpha-synuclein (α-syn) accumulates in Parkinson’s disease (PD), the second most common ND, and recently a “prion-like” mechanism linked to the spreading of α-syn has been suggested for the pathology progression. The Zurzolo group demonstrated that α-syn fibrils spread between neuronal cells inside lysosomes through tunneling nanotubes (TNTs), thin actin-based membrane protrusions mediating intercellular transport of various cargos. As known, lysosomes move along microtubules therefore this research aims to understand how lysosomes can move inside and through actin-based TNTs. The host lab also showed that the transferred α-syn fibrils induce the aggregation of soluble cytosolic α-syn in receiving cells and this project will unravel the mechanism by which α-syn fibrils escape from lysosomes to induce the aggregation of monomers in acceptor cells. In addition, since lysosomal dysfunction is a common feature of NDs, this research will shed light on the functionality and fate of α-syn-loaded lysosomes. Lysosomal dysfunction is also a trait of Lysosomal Storage Diseases (LSDs), a group of about 50 rare inherited metabolic disorders generally caused by the defective function of a specific lysosomal enzyme leading to the lysosomal accumulation of non-degraded materials and neurodegeneration in the forms most severe. This project will investigate the correlation between LSDs and NDs and the possible implications of TNTs in LSDs that represent a new perspective for LSDs etiopathogenesis. By combining my skills in lysosome physiopathology and the host lab expertise in TNTs and PD pathogenesis, this project will provide a deep understanding of the role of lysosomes in NDs pathogenesis and valuable insights to combat these incurable diseases.

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The information about "LYSYT" are provided by the European Opendata Portal: CORDIS opendata.

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