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LocalAdaptation SIGNED

Detecting Local Adaptation with Climate-Informed Spatial Genetic Models

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EC-Contrib. €

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Project "LocalAdaptation" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙839 €
 EC max contribution 1˙999˙839 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙999˙839.00

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 Project objective

Local adaptation, whereby individuals of a population exhibit higher fitness in their local environment compared to that experienced by other populations, has the potential to shape the distribution of genetic diversity and influence speciation. However, detecting and quantifying the extent of local adaptation is challenging, since neutral demographic processes can leave signatures which are hard to distinguish from those of local selection. In this project, I propose to quantify the extent of local adaptation in Anatomically Modern Humans by using climate-informed spatial genetic models (CISGeM) to reconstruct past population sizes, local movements, and range expansions, and thus provide a null model against which the signature of geographically-localised selection can be detected. In CISGeM, demography is affected by local resource availability, which in turn is defined by paleoclimate and paleovegetation reconstructions. By using these additional lines of evidence, it is possible to generate accurate demographic reconstructions for any number of populations, as well as integrating information from both modern and ancient genomes. Such spatially-explicit reconstructions are key for defining the expected neutral patterns due to complex demography, and thus allow us to isolate the signals of selection from this noisy background with high fidelity. The availability of paleoclimate reconstructions also enables formally testing hypotheses about the drivers of selection, integrating the changes in the strength of selection through space and time. While this project will be focused on Anatomically Modern Humans, the framework that I will develop will be applicable to the investigation of local adaptation from genomic data in any species. Such tools are very timely, given the ever-increasing availability of large genetic datasets thanks to the decreasing cost of genotyping and sequencing in both model and non-model organisms.

 Publications

year authors and title journal last update
List of publications.
2017 Liisa Loog, Mark G. Thomas, Ross Barnett, Richard Allen, Naomi Sykes, Ptolemaios D. Paxinos, Ophélie Lebrasseur, Keith Dobney, Joris Peters, Andrea Manica, Greger Larson, Anders Eriksson
Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices
published pages: 1981-1990, ISSN: 0737-4038, DOI: 10.1093/molbev/msx142
Molecular Biology and Evolution 34/8 2020-04-06
2017 Martin Sikora, Andaine Seguin-Orlando, Vitor C. Sousa, Anders Albrechtsen, Thorfinn Korneliussen, Amy Ko, Simon Rasmussen, Isabelle Dupanloup, Philip R. Nigst, Marjolein D. Bosch, Gabriel Renaud, Morten E. Allentoft, Ashot Margaryan, Sergey V. Vasilyev, Elizaveta V. Veselovskaya, Svetlana B. Borutskaya, Thibaut Deviese, Dan Comeskey, Tom Higham, Andrea Manica, Robert Foley, David J. Meltzer, Rasmus Nielsen, Laurent Excoffier, Marta Mirazon Lahr, Ludovic Orlando, Eske Willerslev
Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers
published pages: 659-662, ISSN: 0036-8075, DOI: 10.1126/science.aao1807
Science 358/6363 2020-04-06
2017 Michela Leonardi, Guido Barbujani, Andrea Manica
An earlier revolution: genetic and genomic analyses reveal pre-existing cultural differences leading to Neolithization
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03717-6
Scientific Reports 7/1 2020-04-06
2018 C. L. Scheib, Hongjie Li, Tariq Desai, Vivian Link, Christopher Kendall, Genevieve Dewar, Peter William Griffith, Alexander Mörseburg, John R. Johnson, Amiee Potter, Susan L. Kerr, Phillip Endicott, John Lindo, Marc Haber, Yali Xue, Chris Tyler-Smith, Manjinder S. Sandhu, Joseph G. Lorenz, Tori D. Randall, Zuzana Faltyskova, Luca Pagani, Petr Danecek, Tamsin C. O’Connell, Patricia Martz, Alan S. Boraas, Brian F. Byrd, Alan Leventhal, Rosemary Cambra, Ronald Williamson, Louis Lesage, Brian Holguin, Ernestine Ygnacio-De Soto, JohnTommy Rosas, Mait Metspalu, Jay T. Stock, Andrea Manica, Aylwyn Scally, Daniel Wegmann, Ripan S. Malhi, Toomas Kivisild
Ancient human parallel lineages within North America contributed to a coastal expansion
published pages: 1024-1027, ISSN: 0036-8075, DOI: 10.1126/science.aar6851
Science 360/6392 2020-04-06
2017 Gloria González-Fortes, Eppie R. Jones, Emma Lightfoot, Clive Bonsall, Catalin Lazar, Aurora Grandal-d’Anglade, María Dolores Garralda, Labib Drak, Veronika Siska, Angela Simalcsik, Adina Boroneanţ, Juan Ramón Vidal Romaní, Marcos Vaqueiro Rodríguez, Pablo Arias, Ron Pinhasi, Andrea Manica, Michael Hofreiter
Paleogenomic Evidence for Multi-generational Mixing between Neolithic Farmers and Mesolithic Hunter-Gatherers in the Lower Danube Basin
published pages: 1801-1810.e10, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.05.023
Current Biology 27/12 2020-04-06
2017 Liisa Loog, Marta Mirazón Lahr, Mirna Kovacevic, Andrea Manica, Anders Eriksson, Mark G. Thomas
Estimating mobility using sparse data: Application to human genetic variation
published pages: 12213-12218, ISSN: 0027-8424, DOI: 10.1073/pnas.1703642114
Proceedings of the National Academy of Sciences 114/46 2020-04-06
2018 Kevin G. Daly, Pierpaolo Maisano Delser, Victoria E. Mullin, Amelie Scheu, Valeria Mattiangeli, Matthew D. Teasdale, Andrew J. Hare, Joachim Burger, Marta Pereira Verdugo, Matthew J. Collins, Ron Kehati, Cevdet Merih Erek, Guy Bar-Oz, François Pompanon, Tristan Cumer, Canan Çakırlar, Azadeh Fatemeh Mohaseb, Delphine Decruyenaere, Hossein Davoudi, Özlem Çevik, Gary Rollefson, Jean-Denis Vigne, Roya Khazaeli, Homa Fathi, Sanaz Beizaee Doost, Roghayeh Rahimi Sorkhani, Ali Akbar Vahdati, Eberhard W. Sauer, Hossein Azizi Kharanaghi, Sepideh Maziar, Boris Gasparian, Ron Pinhasi, Louise Martin, David Orton, Benjamin S. Arbuckle, Norbert Benecke, Andrea Manica, Liora Kolska Horwitz, Marjan Mashkour, Daniel G. Bradley
Ancient goat genomes reveal mosaic domestication in the Fertile Crescent
published pages: 85-88, ISSN: 0036-8075, DOI: 10.1126/science.aas9411
Science 361/6397 2020-04-06
2018 Michela Leonardi, Francesco Boschin, Konstantinos Giampoudakis, Robert M. Beyer, Mario Krapp, Robin Bendrey, Robert Sommer, Paolo Boscato, Andrea Manica, David Nogues-Bravo, Ludovic Orlando
Late Quaternary horses in Eurasia in the face of climate and vegetation change
published pages: eaar5589, ISSN: 2375-2548, DOI: 10.1126/sciadv.aar5589
Science Advances 4/7 2020-04-06
2018 Eleanor M.L. Scerri, Mark G. Thomas, Andrea Manica, Philipp Gunz, Jay T. Stock, Chris Stringer, Matt Grove, Huw S. Groucutt, Axel Timmermann, G. Philip Rightmire, Francesco d’Errico, Christian A. Tryon, Nick A. Drake, Alison S. Brooks, Robin W. Dennell, Richard Durbin, Brenna M. Henn, Julia Lee-Thorp, Peter deMenocal, Michael D. Petraglia, Jessica C. Thompson, Aylwyn Scally, Lounès Chikhi
Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter?
published pages: 582-594, ISSN: 0169-5347, DOI: 10.1016/j.tree.2018.05.005
Trends in Ecology & Evolution 33/8 2020-04-06
2016 Anna-Sapfo Malaspinas, Michael C. Westaway, Craig Muller, Vitor C. Sousa, Oscar Lao, Isabel Alves, Anders Bergström, Georgios Athanasiadis, Jade Y. Cheng, Jacob E. Crawford, Tim H. Heupink, Enrico Macholdt, Stephan Peischl, Simon Rasmussen, Stephan Schiffels, Sankar Subramanian, Joanne L. Wright, Anders Albrechtsen, Chiara Barbieri, Isabelle Dupanloup, Anders Eriksson, Ashot Margaryan, Ida Moltke, Irina Pugach, Thorfinn S. Korneliussen, Ivan P. Levkivskyi, J. Víctor Moreno-Mayar, Shengyu Ni, Fernando Racimo, Martin Sikora, Yali Xue, Farhang A. Aghakhanian, Nicolas Brucato, Søren Brunak, Paula F. Campos, Warren Clark, Sturla Ellingvåg, Gudjugudju Fourmile, Pascale Gerbault, Darren Injie, George Koki, Matthew Leavesley, Betty Logan, Aubrey Lynch, Elizabeth A. Matisoo-Smith, Peter J. McAllister, Alexander J. Mentzer, Mait Metspalu, Andrea B. Migliano, Les Murgha, Maude E. Phipps, William Pomat, Doc Reynolds, Francois-Xavier Ricaut, Peter Siba, Mark G. Thomas, Thomas Wales, Colleen Ma’run Wall, Stephen J. Oppenheimer, Chris Tyler-Smith, Richard Durbin, Joe Dortch, Andrea Manica, Mikkel H. Schierup, Robert A. Foley, Marta Mirazón Lahr, Claire Bowern, Jeffrey D. Wall, Thomas Mailund, Mark Stoneking, Rasmus Nielsen, Manjinder S. Sandhu, Laurent Excoffier, David M. Lambert, Eske Willerslev
A genomic history of Aboriginal Australia
published pages: 207-214, ISSN: 0028-0836, DOI: 10.1038/nature18299
Nature 538/7624 2020-04-06
2016 Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander Mörseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag, Jeffrey D. Wall, Alexia Cardona, Reedik Mägi, Melissa A. Wilson Sayres, Sarah Kaewert, Charlotte Inchley, Christiana L. Scheib, Mari Järve, Monika Karmin, Guy S. Jacobs, Tiago Antao, Florin Mircea Iliescu, Alena Kushniarevich, Qasim Ayub, Chris Tyler-Smith, Yali Xue, Bayazit Yunusbayev, Kristiina Tambets, Chandana Basu Mallick, Lehti Saag, Elvira Pocheshkhova, George Andriadze, Craig Muller, Michael C. Westaway, David M. Lambert, Grigor Zoraqi, Shahlo Turdikulova, Dilbar Dalimova, Zhaxylyk Sabitov, Gazi Nurun Nahar Sultana, Joseph Lachance, Sarah Tishkoff, Kuvat Momynaliev, Jainagul Isakova, Larisa D. Damba, Marina Gubina, Pagbajabyn Nymadawa, Irina Evseeva, Lubov Atramentova, Olga Utevska, François-Xavier Ricaut, Nicolas Brucato, Herawati Sudoyo, Thierry Letellier, Murray P. Cox, Nikolay A. Barashkov, Vedrana Škaro, Lejla Mulahasanovic´, Dragan Primorac, Hovhannes Sahakyan, Maru Mormina, Christina A. Eichstaedt, Daria V. Lichman, Syafiq Abdullah, Gyaneshwer Chaubey, Joseph T. S. Wee, Evelin Mihailov, Alexandra Karunas, Sergei Litvinov, Rita Khusainova, Natalya Ekomasova, Vita Akhmetova, Irina Khidiyatova, Damir Marjanović, Levon Yepiskoposyan, Doron M. Behar, Elena Balanovska, Andres Metspalu, Miroslava Derenko, Boris Malyarchuk, Mikhail Voevoda, Sardana A. Fedorova, Ludmila P. Osipova, Marta Mirazón Lahr, Pascale Gerbault, Matthew Leavesley, Andrea Bamberg Migliano, Michael Petraglia, Oleg Balanovsky, Elza K. Khusnutdinova, Ene Metspalu, Mark G. Thomas, Andrea Manica, Rasmus Nielsen, Richard Villems, Eske Willerslev, Toomas Kivisild, Mait Metspalu
Genomic analyses inform on migration events during the peopling of Eurasia
published pages: 238-242, ISSN: 0028-0836, DOI: 10.1038/nature19792
Nature 538/7624 2020-04-06
2015 Eppie R. Jones, Gloria Gonzalez-Fortes, Sarah Connell, Veronika Siska, Anders Eriksson, Rui Martiniano, Russell L. McLaughlin, Marcos Gallego Llorente, Lara M. Cassidy, Cristina Gamba, Tengiz Meshveliani, Ofer Bar-Yosef, Werner Müller, Anna Belfer-Cohen, Zinovi Matskevich, Nino Jakeli, Thomas F. G. Higham, Mathias Currat, David Lordkipanidze, Michael Hofreiter, Andrea Manica, Ron Pinhasi, Daniel G. Bradley
Upper Palaeolithic genomes reveal deep roots of modern Eurasians
published pages: 8912, ISSN: 2041-1723, DOI: 10.1038/ncomms9912
Nature Communications 6 2020-04-06
2015 M. G. Llorente, E. R. Jones, A. Eriksson, V. Siska, K. W. Arthur, J. W. Arthur, M. C. Curtis, J. T. Stock, M. Coltorti, P. Pieruccini, S. Stretton, F. Brock, T. Higham, Y. Park, M. Hofreiter, D. G. Bradley, J. Bhak, R. Pinhasi, A. Manica
Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa
published pages: 820-822, ISSN: 0036-8075, DOI: 10.1126/science.aad2879
Science 350/6262 2020-04-06
2017 Veronika Siska, Eppie Ruth Jones, Sungwon Jeon, Youngjune Bhak, Hak-Min Kim, Yun Sung Cho, Hyunho Kim, Kyusang Lee, Elizaveta Veselovskaya, Tatiana Balueva, Marcos Gallego-Llorente, Michael Hofreiter, Daniel G. Bradley, Anders Eriksson, Ron Pinhasi, Jong Bhak, Andrea Manica
Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago
published pages: e1601877, ISSN: 2375-2548, DOI: 10.1126/sciadv.1601877
Science Advances 3/2 2020-04-06
2017 Eppie R. Jones, Gunita Zarina, Vyacheslav Moiseyev, Emma Lightfoot, Philip R. Nigst, Andrea Manica, Ron Pinhasi, Daniel G. Bradley
The Neolithic Transition in the Baltic Was Not Driven by Admixture with Early European Farmers
published pages: 576-582, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.12.060
Current Biology 27/4 2020-04-06
2016 M. Gallego-Llorente, S. Connell, E. R. Jones, D. C. Merrett, Y. Jeon, A. Eriksson, V. Siska, C. Gamba, C. Meiklejohn, R. Beyer, S. Jeon, Y. S. Cho, M. Hofreiter, J. Bhak, A. Manica, R. Pinhasi
The genetics of an early Neolithic pastoralist from the Zagros, Iran
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31326
Scientific Reports 6/1 2020-04-06

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