Explore the words cloud of the EVOLPROOF project. It provides you a very rough idea of what is the project "EVOLPROOF" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||1˙987˙492 €|
|EC max contribution||1˙987˙492 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||1˙485˙731.00|
|2||CENTRE HOSPITALIER UNIVERSITAIRE MONTPELLIER||FR (MONTPELLIER)||participant||501˙761.00|
There is a threat that evolutionary responses can render vaccines ineffective, as illustrated by the emergence of the increasingly virulent Marek Disease Virus strains in poultry following vaccination campaigns. Assessing the ‘evolution-proof’ nature of vaccines targeting human viruses is challenging because it requires an understanding of the epidemiology, the within-host ecology and the evolutionary potential of the virus. To date, most investigations into the spread of vaccine-resistant strains are theoretical and are rarely constrained by data.
We propose a novel alliance between evolutionary ecology and clinical research to assess the risk of vaccines selecting for resistant or virulent strains. Human papillomaviruses (HPV) and their vaccines provide an ideal study system. However, the scope of the project is wider and encompasses other DNA viruses.
The project is divided into three parts. In Part A, we will decipher HPV within-host dynamics in genital infections. By combining mathematical modelling and longitudinal patient data, we will be able to parameterise within-host models and compare them. In Part B, we will jointly analyse host, virus and genital microbiota diversity using a community ecology approach to understand the infectious process. These results will be integrated into evolutionary epidemiology models allowing for diverse infections. In Part C, we will estimate virus substitution rates and use the results from Parts 1 and 2 to develop a multilevel analysis of HPV evolution in response to vaccination. We will also tackle more general questions related to the evolution of the virulence of human oncoviruses.
A major asset of the project is the collection of clinical data in order to address a major public health issue using ideas and methods from evolutionary ecology. This will set a new agenda for the study of human viral infections and establish a perennial leading research group in Europe.
|year||authors and title||journal||last update|
Carmen LÃa Murall, Massilva Rahmoun, Christian Selinger, Monique Baldellou, Claire Bernat, Marine Bonneau, Vanina BouÃ©, Mathilde Buisson, Guillaume Christophe, Giuseppe Dâ€™Auria, Florence De Taroni, Vincent Foulongne, RÃ©my Froissart, Christelle Graf, Sophie Grasset, Soraya Groc, Christophe Hirtz, Audrey Jaussent, Julie Lajoie, FrÃ©dÃ©rique Lorcy, Eric Picot, Marie-Christine Picot, Jacques Rave
Natural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study
published pages: e025129, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-025129
|BMJ Open 9/6||2019-09-02|
Samuel Alizon, Pierre-Olivier MÃ©thot
Reconciling Pasteur and Darwin to control infectious diseases
published pages: e2003815, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2003815
|PLOS Biology 16/1||2019-08-06|
C.L. Murall, J.L. Abbate, M. Puelma Touzel, E. Allen-Vercoe, S. Alizon, R. Froissart, K. McCann
Invasions of Host-Associated Microbiome Networks
published pages: 201-281, ISSN: , DOI: 10.1016/bs.aecr.2016.11.002
|Advances in Ecological Modeling 57||2019-08-06|
Samuel Alizon, Carmen Murall, Ignacio Bravo
Why Human Papillomavirus Acute Infections Matter
published pages: 293, ISSN: 1999-4915, DOI: 10.3390/v9100293
Carmen LÃa Murall, Samuel Alizon
Modelling the evolution of viral oncogenesis
published pages: 20180302, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0302
|Philosophical Transactions of the Royal Society B: Biological Sciences 374/1773||2019-08-06|
Carmen LÃa Murall, Robert Jackson, Ingeborg Zehbe, Nathalie Boulle, Michel Segondy, Samuel Alizon
Epithelial stratification shapes infection dynamics
published pages: e1006646, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006646
|PLOS Computational Biology 15/1||2019-08-06|
Tsukushi Kamiya, Nicole Mideo, Samuel Alizon
Coevolution of virulence and immunosuppression in multiple infections
published pages: 995-1005, ISSN: 1010-061X, DOI: 10.1111/jeb.13280
|Journal of Evolutionary Biology 31/7||2019-08-06|
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