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Tendon Therapy Train SIGNED

Engineering in vitro microenvironments for translation of cell-based therapies for tendon repair

Total Cost €


EC-Contrib. €






Project "Tendon Therapy Train" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 3˙876˙965 €
 EC max contribution 3˙876˙965 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙062˙698.00
3    THE ROYAL VETERINARY COLLEGE UK (LONDON) participant 546˙575.00
5    PROXY BIOMEDICAL LIMITED IE (Galway) participant 265˙674.00
6    SOFRADIM PRODUCTION SASU FR (TREVOUX) participant 262˙875.00
8    UNIVERSIDADE DO MINHO PT (BRAGA) participant 238˙356.00
10    Aristotle University EL (Thessaloniki) partner 0.00
11    Bose UK (Chatham) partner 0.00
12    Cell Scale CA (Waterloo) partner 0.00
14    Galway Clinic IE (Galway) partner 0.00
15    NAMSA FR (CHASSE SUR RHONE) partner 0.00


 Project objective

Tendon Therapy Train is a research, training and innovation programme for human and equine tendon repair and regeneration that will exploit recent advancements in tissue engineering by self-assembly (TESA) technologies which have led to the clinical translation and commercialisation of advanced therapy medicinal products (ATMPs). Although TESA therapies have the potential to revolutionise healthcare for numerous clinical targets, a lack of researchers with the necessary interdisciplinary skillset to advance the field is limiting clinical translation. Tendon therapy train, a network of 8 beneficiaries and 8 partners (7 universities, 7 companies and 2 hospitals) from six countries across Europe, will train a cohort of 15 researchers to doctoral level in the interdisciplinary area of ATMPs. The innovative credentials of the research and training programme involve engineering suitable ex vivo culture environments that, by mimicking the native tendon tissue milieu (human and equine), will maintain the tenogenic phenotype of tendon derived cells and differentiate non-tendon derived cells (stem cells and dermal fibroblasts) towards the tenogenic lineage, subsequently enabling development of three-dimensional cell-assembled tissue equivalents, the clinical potential of which will be assessed in suitable preclinical models. The comprehensive Tendon Therapy Train programme will equip researchers with transferable inter- and multidisciplinary skills that will further European-based knowledge, innovation, competitiveness and leadership in the field of TESA / ATMP and ultimately enable clinical translation and commercialisation of the developed technologies.


List of deliverables.
Draft Periodic Report Documents, reports 2019-06-27 11:48:00
IDF and patent filings Websites, patent fillings, videos etc. 2019-06-27 11:48:00
Ethics Documents, reports 2019-06-27 11:47:59
Digital media dissemination Websites, patent fillings, videos etc. 2019-06-27 11:48:00
Mid Term review meeting Documents, reports 2019-06-27 11:48:00
Progress report Documents, reports 2019-06-27 11:47:59
Supervisory Board of the Network Documents, reports 2019-06-27 11:47:59

Take a look to the deliverables list in detail:  detailed list of Tendon Therapy Train deliverables.


year authors and title journal last update
List of publications.
2020 Vassey, Matthew J.; Figueredo, Grazziela P.; Scurr, David; Vasilevich, Aliaksei S.; Vermeulen, Steven; Carlier, Aurélie; Luckett, Jeni; Beijer, Nick R.M.; Williams, Paul; Winkler, Dave; de Boer, Jan; Ghaemmaghami, Amir M.; Alexander, Morgan R.
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
published pages: , ISSN: 2198-3844, DOI: 10.1002/advs.201903392
Advanced Science 2020-04-15
2019 Gifford. V., et. at.,
British Society for Matrix Biology Spring 2019 Meeting: “Stroma, Niche, Repair”
published pages: , ISSN: 0959-9673, DOI: 10.1111/iep.12332
International Journal of Experimental Pathology 100/4 2020-04-07
2019 Dimitrios Tsiapalis, Shubhasmin Rana, Meletios Doulgkeroglou, Stephen Kearns, Jack Kelly, Yves Bayon, Dimitrios I. Zeugolis
The effect of aligned electrospun fibers and macromolecular crowding in tenocyte culture
published pages: , ISSN: , DOI: 10.1016/bs.mcb.2019.11.003
Methods in Cell Biology 2020-04-07
2019 Diana Gaspar, Rita Peixoto, Andrea De Pieri, Britta Striegl, Dimitrios I. Zeugolis, Michael Raghunath
Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs
published pages: 126-154, ISSN: 0169-409X, DOI: 10.1016/j.addr.2019.06.002
Advanced Drug Delivery Reviews 146 2020-04-07
2018 Clotilde Théry, Kenneth Witwer
ISEV2018 abstract book
published pages: 1461450, ISSN: 2001-3078, DOI: 10.1080/20013078.2018.1461450
Journal of Extracellular Vesicles 7/sup1 2020-04-07
2019 João Q. Coentro, Andrea De Pieri, Diana Gaspar, Dimitrios Tsiapalis, Dimitrios I. Zeugolis, Yves Bayon
Translational Research Symposium—collaborative efforts as driving forces of healthcare innovation
published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-019-6339-2
Journal of Materials Science: Materials in Medicine 30/12 2020-04-01
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967
Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-03-05
2018 Daniëlle G. Leuning, Nick R. M. Beijer, Nadia A. du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J. Rabelink, Jan de Boer
The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25700-5
Scientific Reports 8/1 2020-03-05
2019 Dimitrios Tsiapalis, Dimitrios I. Zeugolis
Hypoxia Preconditioning of Bone Marrow Mesenchymal Stem Cells Before Implantation in Orthopaedics
published pages: e1040-e1042, ISSN: 1067-151X, DOI: 10.5435/jaaos-d-19-00044
Journal of the American Academy of Orthopaedic Surgeons 27/23 2020-03-05
2020 Dimitrios Tsiapalis, Andrea De Pieri, Kyriakos Spanoudes, Ignacio Sallent, Stephen Kearns, Jack L Kelly, Michael Raghunath, Dimitrios I Zeugolis
The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents
published pages: 25018, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab6412
Biofabrication 12/2 2020-03-05
2020 Aysegul Dede Eren, Ravi Sinha, Egemen Deniz Eren, Yuan Huipin, Sultan Gulce-Iz, Henriette Valster, Lorenzo Moroni, Jasper Foolen, Jan de Boer
Decellularized Porcine Achilles tendon induces anti-inflammatory macrophage phenotype in Vitro and tendon repair in vivo
published pages: 100027, ISSN: 2468-4988, DOI: 10.1016/j.regen.2020.100027
Journal of Immunology and Regenerative Medicine 8 2020-03-05
2019 Anna Sorushanova, Luis M. Delgado, Zhuning Wu, Naledi Shologu, Aniket Kshirsagar, Rufus Raghunath, Anne M. Mullen, Yves Bayon, Abhay Pandit, Michael Raghunath, Dimitrios I. Zeugolis
The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development
published pages: 1801651, ISSN: 0935-9648, DOI: 10.1002/adma.201801651
Advanced Materials 31/1 2020-02-13
2018 A. Dede-Eren, S. Vermeulen, D. Hebels, J. de Boer
Molecular control of tenocyte phenotype through matrix-mediated mechanotransduction
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol 100-B No. Supp_4 2019-06-27
2018 Andrea De Pieri, Sofia Ribeiro, Dimitrios Tsiapalis, David Eglin, Marc Bohner, Peter Dubruel, Philip Procter, Dimitrios I. Zeugolis, Yves Bayon
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
published pages: , ISSN: 0957-4530, DOI: 10.1007/s10856-018-6136-3
Journal of Materials Science: Materials in Medicine 29/8 2019-06-27
2018 A. De Pieri, A. Gorelov, Y. Rochev, D.I. Zeugolis
Thermoresponsive nanofibres for engineering extracellular matrix-rich tissue substitutes
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_16 2019-06-27
2018 D. Tsiapalis, D.I. Zeugolis
A multifactorial toolbox towards tenogenic phenotype maintenance
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_14 2019-06-27
2018 A. Rampin, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolis
Engineering optimal culture conditions to maintain tenogenic phenotype
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_15 2019-06-27
2018 I. Sallent, D.I. Zeugolis
The synergistic effect of topography and substrate rigidity in the development of a collagen scaffold for tendon tissue engineering
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_16 2019-06-27
2018 S. Garnica-Galvez, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolis
Assessment of novel macromolecular crowders to produce cell sheets for scaffold-free musculoskeletal tissue regeneration
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_15 2019-06-27
2018 Guillaumin, S., D.I. Zeugolis
Tenogenic differentiation of mesenchymal stem cells: a co-culture approach
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_16 2019-06-27
2018 A. Dei, W. Chang, A. Sampaio, D. Zeugolis
Development of serum-free culture conditions for differentiation of bone marrow-derived mesenchymal stromal cells from tenocyte-like cells
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_15 2019-06-27
2018 E. Pugliese, S. Korntner, D.I. Zeugolis
Multilayer collagen-based scaffold as delivery vehicles of bioactive molecules for the bone-to-tendon interface regeneration
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_14 2019-06-27
2018 Sarita Kumari, Steven Vermeulen, Ben van der Veer, Aurélie Carlier, Jan de Boer, Deepa Subramanyam
Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells
published pages: 255-266, ISSN: 1937-3368, DOI: 10.1089/ten.teb.2017.0468
Tissue Engineering Part B: Reviews 24/4 2019-06-27
2018 D. Berdecka, P.S. Babo, R.L. Reis, M.E. Gomes
Effect of transforming growth factor beta 3 and growth/differentiation factor 5 on the expression of tendon/ligament markers in human dental pulp stem cells and periodontal ligament cells
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No SUPP_15 2019-06-27
2018 A. Djalali-Cuevas, I. Skoufos, A. Tzora, N. Prassinos, N. Diakakis, D.I. Zeugolid
RNA sequencing and meta-profiling for a better understanding of the musculoskeletal system biology
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No SUPP_15 2019-06-27
2018 S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis
Design and characterization of synthetic biodegradable films for musculoskeletal tissue engineering
published pages: , ISSN: , DOI:
Orthopaedic Proceedings Vol. 100-B, No. SUPP_15 2019-06-27
2018 João Q. Coentro, Eugenia Pugliese, Geoffrey Hanley, Michael Raghunath, Dimitrios I. Zeugolis
Current and upcoming therapies to modulate skin scarring and fibrosis
published pages: digital, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.08.009
Advanced Drug Delivery Reviews Theme issue format 2019-06-27
2019 Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R.M. Beijer, Aysegul Dede Eren, Dimitrios Zeugolis, Jan de Boer
Identification of topographical architectures supporting the phenotype of rat tenocytes
published pages: 277-290, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.10.041
Acta Biomaterialia 83 2019-06-27

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