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AEGIS SIGNED

Accelerated Early staGe drug diScovery

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AEGIS" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH 

Organization address
address: INGOLSTADTER LANDSTRASSE 1
city: NEUHERBERG
postcode: 85764
website: www.helmholtz-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.aegis-itn.eu/
 Total cost 3˙836˙995 €
 EC max contribution 3˙836˙995 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) coordinator 498˙432.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 525˙751.00
3    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 510˙748.00
4    PHILIPPS UNIVERSITAET MARBURG DE (MARBURG) participant 498˙432.00
5    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 265˙226.00
6    NOVARTIS PHARMA AG CH (BASEL) participant 265˙226.00
7    ASTRAZENECA AB SE (SODERTAELJE) participant 263˙659.00
8    RIDGEVIEW INSTRUMENTS AB SE (VANGE) participant 263˙659.00
9    UPPSALA UNIVERSITET SE (UPPSALA) participant 263˙659.00
10    GIOTTO BIOTECH SRL IT (SESTO FIORENTINO FI) participant 258˙061.00
11    UNIWERSYTET JAGIELLONSKI PL (KRAKOW) participant 224˙137.00
12    Astex ES (MADRID) partner 0.00
13    ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE UA (KYIV) partner 0.00
14    EURORDIS - EUROPEAN ORGANISATION FOR RARE DISEASES ASSOCIATION FR (Paris) partner 0.00
15    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) partner 0.00
16    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) partner 0.00
17    Patentanwalt Dietmar Forstmeyer DE (München) partner 0.00
18    RUHR-UNIVERSITAET BOCHUM DE (BOCHUM) partner 0.00
19    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) partner 0.00
20    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) partner 0.00
21    TelesisPharma NL (Groningen) partner 0.00
22    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) partner 0.00
23    UNIVERSITY OF PITTSBURGH US (PITTSBURGH) partner 0.00
24    UNIWERSYTET JAGIELLONSKI PL (Krakow) partner 0.00
25    UNTERNEHMERTUM GMBH DE (GARCHING) partner 0.00

Map

 Project objective

The development of effective novel drugs - especially for rare and neglected diseases - is one of the biggest challenges of the upcoming decades, as illustrated by the recent Ebola outbreak. Moreover, European innovation in new drug registrations is dramatically falling behind compared to the US and Asia. The principal aim of the AEGIS ITN is to implement the first comprehensive, intersectoral cross-disciplinary and structured curriculum for doctoral students in the European Research Area by establishing a unique training platform for the next generation of European researchers in early drug discovery. A significant added value is provided through networking with key European pharmaceutical companies. A key research aim of AEGIS is improving the efficiency and success of early stage drug development by combining innovative methods and techniques to tackle difficult but promising targets (i.e. protein-protein interactions), as potentially valuable drug targets are often neglected due to the high risk associated with their validation. The consortium joins leading academic and industry researchers in an open innovation environment for innovative drug development in Europe. It is supported by several additional partners and stakeholders in the field. Integrated training of the fellows takes place at the host institute and by secondments, research schools and individual training within the AEGIS network. The scientific training includes complementary skills, management, intellectual property rights, fund raising, communication and career planning. AEGIS will improve the availability of a highly skilled workforce for European industries and research, greatly enhance the employability and the career perspectives of young researchers for academia as well as for industry, and will be the seed of a sustainable development in innovative drug discovery, in particular for rare and neglected diseases.

 Deliverables

List of deliverables.
Optimized library Documents, reports 2019-07-09 16:31:29
Web-based MCR platform Documents, reports 2019-07-09 16:31:29
AEGIS Newsletter 1 Websites, patent fillings, videos etc. 2019-07-09 16:31:29
Schools 1 Documents, reports 2019-07-09 16:31:29
Virtual screening & de novo design Documents, reports 2019-07-09 16:31:29
Announcement of the Supervisory Board Other 2019-07-09 16:31:29
Method development induced pockets Documents, reports 2019-07-09 16:31:29
Report 1 about Public Engagement Activities Other 2019-07-09 16:31:29

Take a look to the deliverables list in detail:  detailed list of AEGIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Markella Konstantinidou, Francesca Magari, Fandi Sutanto, Jörg Haupenthal, Varsha R. Jumde, M. Yagiz Ünver, Andreas Heine, Carlos Jamie Camacho, Anna K. H. Hirsch, Gerhard Klebe, Alexander Dömling
Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach
published pages: online, ISSN: 1860-7179, DOI: 10.1002/cmdc.202000024
ChemMedChem online 2020-04-01
2020 Softley CA, Zak KM, Bostock MJ, Fino R, Zhoua RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowic GM
Structure and molecular recognition mechanism of IMP-13 metallo-β-lactamase
published pages: , ISSN: 1098-6596, DOI:
Antimicrobial Agents and Chemotherapy accepted 2020-04-01
2020 R. Fino, R. Byrne, C.A. Softley, M. Sattler, G. Schneider, G.M. Popowicz
Introducing the CSP Analyzer: A novel Machine Learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening
published pages: 603-611, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2020.02.015
Computational and Structural Biotechnology Journal 18 2020-03-31
2020 Sara Marie Øie Solbak, Jie Zang, Dilip Narayanan, Lars Jakobsen Høj, Saskia Bucciarelli, Charlotte Softley, Sebastian Meier, Annette Eva Langkilde, Charlotte Held Gotfredsen, Michael Sattler, Anders Bach
Developing Inhibitors of the p47phox–p22phox Protein–Protein Interaction by Fragment-Based Drug Discovery
published pages: 1156-1177, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01492
Journal of Medicinal Chemistry 63/3 2020-03-31
2019 Qian Wang, Angelina Osipyan, Markella Konstantinidou, Roberto Butera, Kumchok C. Mgimpatsang, Svitlana V. Shishkina, Alexander Dömling
Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles
published pages: 12148-12156, ISSN: 0022-3263, DOI: 10.1021/acs.joc.9b01258
The Journal of Organic Chemistry 84/18 2020-03-31
2018 Varsha R. Jumde, Milon Mondal, Robin M. Gierse, M. Yagiz Unver, Francesca Magari, Roos C. W. van Lier, Andreas Heine, Gerhard Klebe, Anna K. H. Hirsch
Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin
published pages: 2266-2270, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800446
ChemMedChem 13/21 2020-03-31
2019 Ave Kuusk, João Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B. Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G. Doveston
Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ
published pages: 262-271, ISSN: 1554-8929, DOI: 10.1021/acschembio.9b00893
ACS Chemical Biology 15/1 2020-03-31
2020 Lukas Friedrich, Ryan Byrne, Aaron Treder, Inderjeet Singh, Christoph Bauer, Thomas Gudermann, Michael Mederos y Schnitzler, Ursula Storch, Gisbert Schneider
Shape Similarity by Fractal Dimensionality: An Application in the de novo Design of (−)‐Englerin A Mimetics
published pages: online, ISSN: 1860-7179, DOI: 10.1002/cmdc.202000017
ChemMedChem online 2020-03-31
2018 Irene Russo Krauss, Valeria Napolitano, Luigi Petraccone, Romualdo Troisi, Vera Spiridonova, Carlo Andrea Mattia, Filomena Sica
Duplex/quadruplex oligonucleotides: Role of the duplex domain in the stabilization of a new generation of highly effective anti-thrombin aptamers
published pages: 1697-1705, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2017.10.033
International Journal of Biological Macromolecules 107 2020-03-31
2018 Ana S. Pires, Cláudia R. Marques, João C. Encarnação, Ana M. Abrantes, Inês A. Marques, Mafalda Laranjo, Rui Oliveira, João E. Casalta-Lopes, Ana C. Gonçalves, Ana B. Sarmento-Ribeiro, Maria F. Botelho
Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth
published pages: online, ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00911
Frontiers in Physiology 9 2020-03-31
2018 João Crispim Encarnação, Ana Salomé Pires, Renata Alexandra Amaral, Telmo José Gonçalves, Mafalda Laranjo, João Eduardo Casalta-Lopes, Ana Cristina Gonçalves, Ana Bela Sarmento-Ribeiro, Ana Margarida Abrantes, Maria Filomena Botelho
Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells
published pages: 183-192, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2018.02.018
The Journal of Nutritional Biochemistry 56 2020-03-31
2018 Romualdo Troisi, Valeria Napolitano, Vera Spiridonova, Irene Russo Krauss, Filomena Sica
Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
published pages: 12177-12185, ISSN: 0305-1048, DOI: 10.1093/nar/gky990
Nucleic Acids Research 46/22 2020-03-31
2016 Irene Russo Krauss, Vera Spiridonova, Andrea Pica, Valeria Napolitano, Filomena Sica
Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
published pages: 983-991, ISSN: 0305-1048, DOI: 10.1093/nar/gkv1384
Nucleic Acids Research 44/2 2020-03-31
2020 Ekaterina L. Ratkova, Maciej Dawidowski, Valeria Napolitano, Grzegorz Dubin, Roberto Fino, Michael S. Ostertag, Michael Sattler, Grzegorz Popowicz, Igor V. Tetko
Water envelope has a critical impact on the design of protein–protein interaction inhibitors
published pages: \"https://pubs.r, ISSN: 1359-7345, DOI: 10.1039/c9cc07714f
Chemical Communications \"https://pubs.rsc.org/en/conte 2020-03-31
2018 Sergey Lunev, Sabine Butzloff, Atilio R. Romero, Marleen Linzke, Fernando A. Batista, Kamila A. Meissner, Ingrid B. Müller, Alaa Adawy, Carsten Wrenger, Matthew R. Groves
Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro
published pages: e0195011, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0195011
PLOS ONE 13/4 2019-07-09
2018 João Crispim Encarnação, Tim Schulte, Adnane Achour, Hanna Björkelund, Karl Andersson
Detecting ligand interactions in real time on living bacterial cells
published pages: 4193-4201, ISSN: 0175-7598, DOI: 10.1007/s00253-018-8919-3
Applied Microbiology and Biotechnology 102/9 2019-07-09

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