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FIDELIO SIGNED

Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FIDELIO project word cloud

Explore the words cloud of the FIDELIO project. It provides you a very rough idea of what is the project "FIDELIO" about.

biologists    risk    mechanisms    bmd    imposes    webinars    artificial    genetic    lack    training    entrepreneurial    morbidity    trained    clinicians    burden    aging    multidisciplinary    stage    largely    transferable    society    epidemiologists    emerged    fragility    cutting    diabetic    edge    employ    develops    courses    esrs    hormones    mineral    interdisciplinary    bone    stratification    patient    skills    date    relative    markers    mortality    joint    technologies    techniques    preclinical    density    offers    professional    quality    despite    predictive    broad    geneticists    collaborative    secondments    disease    form    entrepreneurs    engineers    supporting    experts    cohorts    anabolic    worldwide    fracture    subsequent    epidemic    treatment    fidelio    area    vitro    intelligence    interventions    companies    databases    unknown    altered    unravelling    models    osteoporosis    individual    residential    healthcare    mostly    derive    environment    biological    fractures    fold    mellitus    succeed    imaging    individualized    normal    suggests    diabetes   

Project "FIDELIO" data sheet

The following table provides information about the project.

Coordinator		 TECHNISCHE UNIVERSITAET DRESDEN 

Organization address
address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069
website: http://www.tu-dresden.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 3˙810˙146 €
 EC max contribution 3˙810˙146 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) coordinator 505˙576.00
2    SYDDANSK UNIVERSITET DK (ODENSE M) participant 595˙044.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 562˙553.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 531˙239.00
5    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 505˙576.00
6    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
7    UNIVERSITE DE GENEVE CH (GENEVE) participant 281˙276.00
8    TAMIRNA GMBH AT (WIEN) participant 264˙207.00
9    UNIVERSITA CAMPUS BIO MEDICO DI ROMA IT (ROMA) participant 261˙499.00

Map

 Project objective

Diabetes mellitus has emerged as a novel risk factor for fragility fractures. While in type 1 diabetes the 3-fold overall relative risk for fractures may mostly derive from low bone mineral density (BMD) likely due to the lack of the bone-anabolic hormones, in type 2 diabetes, the fracture risk is increased about 2-fold, despite a normal or even higher BMD. This suggests that bone fragility in each form of diabetes develops by distinct mechanisms that to date remain largely unknown and may require an individualized approach for effective treatment. As the diabetes epidemic is increasing worldwide with aging, and the fractures that are associated with diabetes cause an increase in morbidity, mortality, and healthcare costs, diabetes-induced osteoporosis imposes a significant burden on our society and our healthcare system.

FIDELIO offers a comprehensive, multidisciplinary training program for Early Stage Researchers (ESRs) in this emerging field, unravelling i) the biological mechanisms that contribute to altered bone quality parameters with subsequent bone fragility in diabetes, ii) identify predictive markers for patient stratification and individualized interventions, and iii) develop novel imaging techniques to determine bone quality aspects. The research will employ well-defined patient cohorts, preclinical models of diabetic bone disease, in vitro studies, genetic databases, artificial intelligence, and cutting-edge imaging technologies in a highly collaborative and interdisciplinary environment. ESRs will be trained through individual research projects, secondments, residential courses, and webinars provided by a broad range of experts, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, as well as companies supporting this important area of research. The joint training programme will also develop transferable and entrepreneurial skills to help the ESRs succeed in their choice of professional future.

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