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FIDELIO SIGNED

Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FIDELIO project word cloud

Explore the words cloud of the FIDELIO project. It provides you a very rough idea of what is the project "FIDELIO" about.

disease    preclinical    interdisciplinary    employ    clinicians    models    webinars    markers    intelligence    subsequent    individual    unravelling    companies    aging    genetic    vitro    skills    collaborative    individualized    supporting    residential    imposes    secondments    diabetic    fragility    fracture    suggests    fidelio    biologists    mineral    worldwide    epidemiologists    despite    joint    mostly    databases    technologies    fractures    date    risk    largely    professional    bmd    bone    techniques    stratification    predictive    artificial    area    society    osteoporosis    succeed    engineers    burden    derive    experts    entrepreneurial    morbidity    treatment    biological    geneticists    esrs    courses    relative    altered    cohorts    broad    epidemic    quality    lack    mechanisms    cutting    imaging    interventions    emerged    mortality    patient    diabetes    stage    trained    develops    anabolic    healthcare    transferable    normal    fold    mellitus    entrepreneurs    density    offers    training    unknown    hormones    multidisciplinary    environment    edge    form   

Project "FIDELIO" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET DRESDEN 

Organization address
address: HELMHOLTZSTRASSE 10
city: DRESDEN
postcode: 1069
website: http://www.tu-dresden.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙810˙146 €
 EC max contribution 3˙810˙146 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) coordinator 505˙576.00
2    SYDDANSK UNIVERSITET DK (ODENSE M) participant 595˙044.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 562˙553.00
4    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 531˙239.00
5    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 505˙576.00
6    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 303˙172.00
7    UNIVERSITE DE GENEVE CH (GENEVE) participant 281˙276.00
8    TAMIRNA GMBH AT (WIEN) participant 264˙207.00
9    UNIVERSITA CAMPUS BIO MEDICO DI ROMA IT (ROMA) participant 261˙499.00

Map

 Project objective

Diabetes mellitus has emerged as a novel risk factor for fragility fractures. While in type 1 diabetes the 3-fold overall relative risk for fractures may mostly derive from low bone mineral density (BMD) likely due to the lack of the bone-anabolic hormones, in type 2 diabetes, the fracture risk is increased about 2-fold, despite a normal or even higher BMD. This suggests that bone fragility in each form of diabetes develops by distinct mechanisms that to date remain largely unknown and may require an individualized approach for effective treatment. As the diabetes epidemic is increasing worldwide with aging, and the fractures that are associated with diabetes cause an increase in morbidity, mortality, and healthcare costs, diabetes-induced osteoporosis imposes a significant burden on our society and our healthcare system.

FIDELIO offers a comprehensive, multidisciplinary training program for Early Stage Researchers (ESRs) in this emerging field, unravelling i) the biological mechanisms that contribute to altered bone quality parameters with subsequent bone fragility in diabetes, ii) identify predictive markers for patient stratification and individualized interventions, and iii) develop novel imaging techniques to determine bone quality aspects. The research will employ well-defined patient cohorts, preclinical models of diabetic bone disease, in vitro studies, genetic databases, artificial intelligence, and cutting-edge imaging technologies in a highly collaborative and interdisciplinary environment. ESRs will be trained through individual research projects, secondments, residential courses, and webinars provided by a broad range of experts, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, as well as companies supporting this important area of research. The joint training programme will also develop transferable and entrepreneurial skills to help the ESRs succeed in their choice of professional future.

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