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MAGNEURON SIGNED

Hijacking cell signalling pathways with magnetic nanoactuators for remote-controlled stemcell therapies of neurodegenerative disorders

Total Cost €

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EC-Contrib. €

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Partnership

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 MAGNEURON project word cloud

Explore the words cloud of the MAGNEURON project. It provides you a very rough idea of what is the project "MAGNEURON" about.

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Project "MAGNEURON" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://magneuron.eu/
 Total cost 3˙473˙026 €
 EC max contribution 3˙473˙026 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 638˙750.00
2    UNIVERSITY OF KEELE UK (KEELE) participant 860˙125.00
3    RUHR-UNIVERSITAET BOCHUM DE (BOCHUM) participant 681˙875.00
4    UNIVERSITAET OSNABRUECK DE (OSNABRUECK) participant 654˙000.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 488˙276.00
6    EFFICIENT INNOVATION SAS FR (CASTELNAU LE LEZ) participant 150˙000.00

Map

 Project objective

Neurodegenerative diseases, such as Parkinson’s disease, are a major public health issue given the aging population in Europe and beyond. While curative pharmacological treatment of these diseases is not in sight, cell replacement therapies (CTs) are considered very promising, in particular with the advent of stem-cell reprogramming technologies. However, a fundamental challenge in the medical application of CTs in the brain of patients lies in the lack of control of cell behaviour at the site of transplantation, and particularly their differentiation and oriented growth. The aim of this project is to introduce a fundamentally new concept for remote control of cellular functions by means of magnetic manipulation. The technology is based on magnetic nanoparticles functionalized with proteins involved in cellular signalling cascades. These biofunctionalized MNPs (bMNPs) will be delivered into target cells, where they act as intracellular signalling platforms activatable in a spatially and temporally controlled manner by external magnetic fields. The project will focus on engineering these tools for the control of neuronal cell programming and fibre outgrowth by hijacking Wnt and neurotrophin signalling, respectively, with the ulti-mate objective of advancing cell replacement therapies for PD using dopaminergic precursor neurons. To achieve this ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edge know-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronal cell differentiation, stem-cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise, a novel, versatile technology for magnetic control of intracellular signalling is envis-aged, which will be a breakthrough for remote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injuries within the following decade.

 Deliverables

List of deliverables.
Consolidated Data Management Plan Open Research Data Pilot 2020-04-16 13:47:52
Identification and assessment of neuronal differentiation and axonal outgrowth Documents, reports 2020-04-16 13:47:35
Dissemination Strategy report 2 Documents, reports 2020-04-16 13:49:00
Systematic analysis of the cell differentiation response to signalling perturbations Documents, reports 2020-04-16 13:47:25
Protocols for activation of neuronal differentiation through key receptor tags Documents, reports 2020-04-16 13:47:14
Final workshop Documents, reports 2020-04-16 13:46:52
Device for parallelized stimulation and high-throughput assay Demonstrators, pilots, prototypes 2020-04-16 13:47:03
Final Dissemination Strategy report Documents, reports 2020-04-16 13:46:41
Characterization of magnetic manipulation in cells Documents, reports 2020-04-07 20:22:13
Recombinant ferritin-based MNPs Documents, reports 2020-04-07 20:22:13
Intermediate workshop Documents, reports 2020-04-07 20:22:13
Dispersions of silica core shell MNPs Documents, reports 2020-04-07 20:22:13
Activation of intracellular membrane-anchored small G-proteins by cytosolic MNPs Documents, reports 2020-04-07 20:22:13
Dispersions of stabilized MNPs Documents, reports 2020-04-07 20:22:13
Dissemination Strategy report 1 Documents, reports 2020-04-07 20:22:13
Data Management Plan Documents, reports 2020-04-07 20:22:13
MAGNEURON website Websites, patent fillings, videos etc. 2020-04-07 20:22:13
Dissemination Strategy plan Documents, reports 2020-04-07 20:22:13
MAGNEURON brochure Documents, reports 2020-04-07 20:22:13

Take a look to the deliverables list in detail:  detailed list of MAGNEURON deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Marie Kappen, Domenik Liße, Jacob Piehler
Nanowerkzeuge für regeneratives Nervenwachstum.
published pages: 16, ISSN: , DOI:
Gesundheit für Mensch, Tier und Pflanze 2019 2020-04-07
2019 Manon Debayle, Elie Balloul, Fatimata Dembele, Xiangzhen Xu, Mohamed Hanafi, Francois Ribot, Cornelia Monzel, Mathieu Coppey, Alexandra Fragola, Maxime Dahan, Thomas Pons, Nicolas Lequeux
Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation?
published pages: 119357, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2019.119357
Biomaterials 219 2020-04-07
2018 Loïc Toraille, Koceila Aïzel, Élie Balloul, Chiara Vicario, Cornelia Monzel, Mathieu Coppey, Emilie Secret, Jean-Michel Siaugue, João Sampaio, Stanislas Rohart, Nicolas Vernier, Louise Bonnemay, Thierry Debuisschert, Loïc Rondin, Jean-François Roch, Maxime Dahan
Optical Magnetometry of Single Biocompatible Micromagnets for Quantitative Magnetogenetic and Magnetomechanical Assays
published pages: 7635-7641, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b03222
Nano Letters 18/12 2020-04-07
2019 Michael Rotherham, Tasmin Nahar, Timothy Goodman, Neil Telling, Monte Gates, Alicia El Haj
Magnetic Mechanoactivation of Wnt Signaling Augments Dopaminergic Differentiation of Neuronal Cells
published pages: 1900091, ISSN: 2366-7478, DOI: 10.1002/adbi.201900091
Advanced Biosystems 2020-04-07
2019 Hendrik Schöneborn, Fabian Raudzus, Emilie Secret, Nils Otten, Aude Michel, Jérome Fresnais, Christine Ménager, Jean-Michel Siaugue, Holm Zaehres, Irmgard D. Dietzel, Rolf Heumann
Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins
published pages: 32, ISSN: 2079-4983, DOI: 10.3390/jfb10030032
Journal of Functional Biomaterials 10/3 2020-04-07
2018 Hendrik Schöneborn, Fabian Raudzus, Mathieu Coppey, Sebastian Neumann, Rolf Heumann
Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons
published pages: 4052, ISSN: 1422-0067, DOI: 10.3390/ijms19124052
International Journal of Molecular Sciences 19/12 2020-04-07
2018 Meray Serdar, Josephine Herz, Karina Kempe, Elke Winterhager, Holger Jastrow, Rolf Heumann, Ursula Felderhoff-Müser, Ivo Bendix
Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury
published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2018.00175
Frontiers in Neurology 9 2020-04-07
2016 Panagiotis S. Athanasopoulos, Wright Jacob, Sebastian Neumann, Miriam Kutsch, Dirk Wolters, Eng K. Tan, Zoë Bichler, Christian Herrmann and Rolf Heumann
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2
published pages: 541-554, ISSN: 1437-4315, DOI: 10.1515/hsz-2015-0189
Biological Chemistry 397(6) February 19, 2016 2020-04-07
2016 Drees, C. Raj, A. N. Kurre, R. Busch, K. B. Haase, M. Piehler, J.
Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells
published pages: 11668-11672, ISSN: 1433-7851, DOI: 10.1002/anie.201603028
Angew. Chem. Int. Ed. Engl. 55 (38) Sep 12 2020-04-07

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