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MARA SIGNED

Molecular Analytical Robotics Assays

Total Cost €

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EC-Contrib. €

0

Partnership

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 MARA project word cloud

Explore the words cloud of the MARA project. It provides you a very rough idea of what is the project "MARA" about.

substantial    first    concerning    mimicry    performed    detection    sensor    young    spread    destroy    pathogens    combine    breakthrough    employs    science    moro    hours    acids    medicine    economic    experts    treatment    nucleic    limitations    realisation    pathogen    infectious    cancer    therapeutic    contain    biotechnology    replacement    enzymes    energy    create    independent    team    cells    biomedical    industry    clinical    antibiotic    breakthroughs    toolkit    multidrug    water    vision    diseases    proof    antigens    molecular    bacterial    technologies    creation    profile    disciplines    release    characterise    audena    revolutionary    instruments    sophisticated    radically    stable    autonomous    class    lysis    meet    protein    anticipates    intracellular    laboratory    complementary    mechanisms    mara    substances    pointed    pcr    applicable    cultivation    dna    manufacturing    agent    soluble    tests    characterising    either    resistance    artificial    robot    diagnostic    scientist    resistant    multidisciplinary   

Project "MARA" data sheet

The following table provides information about the project.

Coordinator
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH 

Organization address
address: GIEFINGGASSE 4
city: WIEN
postcode: 1210
website: http://www.ait.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.maraproject.eu/
 Total cost 3˙996˙477 €
 EC max contribution 3˙996˙477 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) coordinator 1˙649˙517.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 647˙250.00
3    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG DE (FREIBURG) participant 581˙250.00
4    Pure Biologics Spolka Akcyjna PL (WROCLAW) participant 570˙000.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 548˙460.00
6    APTA BIOSCIENCES LIMITED UK (LEDBURY HEREFORDSHIRE) participant 0.00

Map

 Project objective

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.

 Deliverables

List of deliverables.
DNA origami design software Open Research Data Pilot 2019-05-07 20:49:08
Data management plan Documents, reports 2019-05-24 18:18:49
Collaborative website Websites, patent fillings, videos etc. 2019-05-24 18:18:44

Take a look to the deliverables list in detail:  detailed list of MARA deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers
ArnS, a kinase involved in starvation-induced archaellum expression
published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550
Molecular Microbiology 103/1 2019-05-07
2018 H. Miao, E. De Llano, T. Isenberg, M. E. Gröller, I. Barišić, I. Viola
DimSUM: Dimension and Scale Unifying Map for Visual Abstraction of DNA Origami Structures
published pages: 403-413, ISSN: 0167-7055, DOI: 10.1111/cgf.13429
Computer Graphics Forum 37/3 2019-05-07
2018 Haichao Miao, Elisa De Llano, Johannes Sorger, Yasaman Ahmadi, Tadija Kekic, Tobias Isenberg, M. Eduard Groller, Ivan Barisic, Ivan Viola
Multiscale Visualization and Scale-Adaptive Modification of DNA Nanostructures
published pages: 1014-1024, ISSN: 1077-2626, DOI: 10.1109/TVCG.2017.2743981
IEEE Transactions on Visualization and Computer Graphics 24/1 2019-05-07
2016 Dominik Esser, Lena Hoffmann, Trong Khoa Pham, Christopher Bräsen, Wen Qiu, Phillip C. Wright, Sonja-Verena Albers, Bettina Siebers
Protein phosphorylation and its role in archaeal signal transduction
published pages: 625-647, ISSN: 1574-6976, DOI: 10.1093/femsre/fuw020
FEMS Microbiology Reviews 40/5 2019-05-07
2017 M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers
ArnS, a kinase involved in starvation-induced archaellum expression
published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550
Molecular Microbiology 103/1 2019-05-07

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