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MARA SIGNED

Molecular Analytical Robotics Assays

Total Cost €

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EC-Contrib. €

0

Partnership

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 MARA project word cloud

Explore the words cloud of the MARA project. It provides you a very rough idea of what is the project "MARA" about.

bacterial    enzymes    concerning    technologies    cancer    multidisciplinary    manufacturing    create    proof    soluble    biomedical    complementary    diseases    pointed    clinical    replacement    industry    protein    characterise    team    multidrug    acids    robot    instruments    biotechnology    breakthrough    independent    applicable    treatment    substantial    mimicry    sensor    intracellular    laboratory    creation    employs    pathogen    class    destroy    hours    stable    resistance    autonomous    dna    moro    cells    audena    young    economic    characterising    anticipates    artificial    combine    tests    substances    nucleic    meet    contain    cultivation    experts    either    scientist    therapeutic    disciplines    limitations    toolkit    first    breakthroughs    vision    medicine    realisation    antibiotic    pathogens    diagnostic    sophisticated    profile    infectious    detection    energy    radically    resistant    antigens    mara    agent    release    molecular    revolutionary    science    lysis    spread    performed    mechanisms    water    pcr   

Project "MARA" data sheet

The following table provides information about the project.

Coordinator
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH 

Organization address
address: GIEFINGGASSE 4
city: WIEN
postcode: 1210
website: http://www.ait.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.maraproject.eu/
 Total cost 3˙996˙477 €
 EC max contribution 3˙996˙477 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) coordinator 1˙649˙517.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 647˙250.00
3    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG DE (FREIBURG) participant 581˙250.00
4    Pure Biologics Spolka Akcyjna PL (WROCLAW) participant 570˙000.00
5    AARHUS UNIVERSITET DK (AARHUS C) participant 548˙460.00
6    APTA BIOSCIENCES LIMITED UK (LEDBURY HEREFORDSHIRE) participant 0.00

Map

 Project objective

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.

 Deliverables

List of deliverables.
DNA origami design software Open Research Data Pilot 2019-05-07 20:49:08
Data management plan Documents, reports 2019-05-24 18:18:49
Collaborative website Websites, patent fillings, videos etc. 2019-05-24 18:18:44

Take a look to the deliverables list in detail:  detailed list of MARA deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers
ArnS, a kinase involved in starvation-induced archaellum expression
published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550
Molecular Microbiology 103/1 2019-05-07
2018 H. Miao, E. De Llano, T. Isenberg, M. E. Gröller, I. Barišić, I. Viola
DimSUM: Dimension and Scale Unifying Map for Visual Abstraction of DNA Origami Structures
published pages: 403-413, ISSN: 0167-7055, DOI: 10.1111/cgf.13429
Computer Graphics Forum 37/3 2019-05-07
2018 Haichao Miao, Elisa De Llano, Johannes Sorger, Yasaman Ahmadi, Tadija Kekic, Tobias Isenberg, M. Eduard Groller, Ivan Barisic, Ivan Viola
Multiscale Visualization and Scale-Adaptive Modification of DNA Nanostructures
published pages: 1014-1024, ISSN: 1077-2626, DOI: 10.1109/TVCG.2017.2743981
IEEE Transactions on Visualization and Computer Graphics 24/1 2019-05-07
2016 Dominik Esser, Lena Hoffmann, Trong Khoa Pham, Christopher Bräsen, Wen Qiu, Phillip C. Wright, Sonja-Verena Albers, Bettina Siebers
Protein phosphorylation and its role in archaeal signal transduction
published pages: 625-647, ISSN: 1574-6976, DOI: 10.1093/femsre/fuw020
FEMS Microbiology Reviews 40/5 2019-05-07
2017 M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers
ArnS, a kinase involved in starvation-induced archaellum expression
published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550
Molecular Microbiology 103/1 2019-05-07

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