Explore the words cloud of the DynaMech project. It provides you a very rough idea of what is the project "DynaMech" about.
The following table provides information about the project.
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
|Coordinator Country||Netherlands [NL]|
|Total cost||2˙132˙500 €|
|EC max contribution||2˙132˙500 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-02-01 to 2021-01-31|
Take a look of project's partnership.
|1||PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV||NL (UTRECHT)||coordinator||2˙132˙500.00|
'Transcription is a stepwise process that is inherently dynamic. Different types of transcription factors are continuously interacting off and onto DNA, 'searching' for appropriate interactions - each bringing different functions into play. The rates with which these factors interact with chromatin, their association and dissociation rates, dictate the outcome of 'steady-state', developmental and rapidly responsive regulatory programs. Given the central role of transcription factors in biology and disease, it is remarkable that we know next to nothing about the dynamics of transcription factor-chromatin interactions.
The objective of DynaMech is to implement technologies that will allow us to measure transcription factor binding dynamics (on- and off-rates) genome-wide, at binding site resolution. This will be applied to gain a systematic understanding of how these dynamics effect the function of transcription factors. Analyses will encompass components of the RNA polymerase II pre-initiation complex in yeast, as well as a comprehensive set of gene-specific transcription factors. For each of these factors we will determine the on- and off-rates genome-wide as well as the degree to which the mRNA synthesis rates from all promoters are dependent on the factor. This data will all be analysed in the context of nucleosome binding dynamics to understand the general principles of how chromatin-transcripton factor binding dynamics shape regulatory mechanisms. Through modelling promoter output and by additional perturbations, these principles will be explored to understand which properties of regulatory DNA determine differential transcription factor dynamics thereby causing differential promoter behaviour.
We are as yet far from predicting regulatory outcome from regulatory sequence. The long-term aim of this work is to bring this closer, by bringing into play the almost completely unexplored aspect of transcription factor-chromatin interaction dynamics. '
|year||authors and title||journal||last update|
Wim J de Jonge, Eoghan O\'Duibhir, Philip Lijnzaad, Dik van Leenen, Marian JA Groot Koerkamp, Patrick Kemmeren, Frank CP Holstege
Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters
published pages: 274-290, ISSN: 0261-4189, DOI: 10.15252/embj.201695621
|The EMBO Journal 36/3||2019-07-08|
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The information about "DYNAMECH" are provided by the European Opendata Portal: CORDIS opendata.
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