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INTENS SIGNED

INtestinal Tissue ENgineering Solution

Total Cost €

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EC-Contrib. €

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Partnership

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 INTENS project word cloud

Explore the words cloud of the INTENS project. It provides you a very rough idea of what is the project "INTENS" about.

surgery    lost    severe    90    reconstruction    expertise    eminent    cure    transplantation    world    year    cell    solutions    options    removed    function    sbs    designed    translation    internationally    true    entire    sub    combining    fulfilling    biology    renders    functional    offers    translate    medicine    disciplinary    groups    possesses    children    strategy    overcoming    public    complete    transplant    tissue    trial    organs    parenteral    survival    molecular    short    uniquely    avoiding    hospitals    positioned    nutritional    pn    record    economic    ideal    solution    scaffold    scientists    team    compromised    engineering    rates    engineered    track    syndrome    intestinal    combination    option    rate    effort    shortage    industry    small    source    universities    few    patient    life    nutrition    60    immunosuppression    intravenous    bowel    regenerative    incapable    missing    occurs    optimal    adults    patients    autologous    basic    preferred    protocol    mortality    intestine    quality    engaging    respectively    55    clinical    infrastructure   

Project "INTENS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.intens.info/
 Total cost 7˙101˙716 €
 EC max contribution 5˙990˙464 € (84%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙300˙713.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 921˙160.00
3    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 825˙625.00
4    CHILDREN'S HOSPITAL LOS ANGELES US (LOS ANGELES,CA) participant 810˙775.00
5    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 720˙000.00
6    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) participant 682˙163.00
7    STEMCELL TECHNOLOGIES UK LTD UK (CAMBRIDGE) participant 629˙495.00
8    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 100˙533.00
9    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) participant 0.00

Map

 Project objective

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children and adults who have lost their bowel. PN offers a low survival rate, compromised quality of life, and the economic cost for each patient is estimated to be 55,000 euro/year. Small intestinal transplant is also an option with one-year and 4-year survival rates of 90% and 60% respectively. However, because of the shortage of organs, high mortality, the severe side effects of immunosuppression and low quality of life, this is still a sub-optimal solution. The objective of this programme is to deliver a functional bowel reconstruction to patients with SBS through an autologous tissue engineering strategy, overcoming the shortage of organs, and avoiding the need for immunosuppression. It will be achieved by identifying the best autologous cell source; providing the ideal scaffold; engineering functional intestine for transplantation and engaging with patients, scientists and public. The work is designed to lead directly to a clinical trial for the application of the optimal protocol for tissue-engineered intestine. The consortium is uniquely positioned to complete this ambitious effort as we have an internationally pre-eminent, multi-disciplinary team, which possesses a combination of expertise from basic molecular biology, engineering, and surgery, combining knowledge from universities, hospitals and industry. Importantly we are one of the few groups in the world with experience, infrastructure, and track record to translate regenerative medicine solutions to patients, including true clinical translation of tissue engineered organs.

 Deliverables

List of deliverables.
Obtaining tissue Documents, reports 2020-02-03 16:27:04
Tool for engaging the public Other 2020-02-03 16:27:04
Website Websites, patent fillings, videos etc. 2020-02-03 16:27:03

Take a look to the deliverables list in detail:  detailed list of INTENS deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
published pages: 35-49.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.11.001
Cell Stem Cell 22/1 2020-02-03
2018 Giuliana Rossi, Andrea Manfrin, Matthias P. Lutolf
Progress and potential in organoid research
published pages: 671-687, ISSN: 1471-0056, DOI: 10.1038/s41576-018-0051-9
Nature Reviews Genetics 19/11 2020-02-03
2018 Alfonso Martinez Arias, Matthias P. Lutolf
Mammalian body plan engineering: Lessons and challenges
published pages: 50-56, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.07.007
Current Opinion in Systems Biology 11 2020-02-03
2017 Yoji Tabata, Matthias P. Lutolf
Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44711
Scientific Reports 7/1 2020-02-03

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The information about "INTENS" are provided by the European Opendata Portal: CORDIS opendata.

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