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INTENS SIGNED

INtestinal Tissue ENgineering Solution

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

INTENS project word cloud

Explore the words cloud of the INTENS project. It provides you a very rough idea of what is the project "INTENS" about.

lost option scaffold eminent engineering internationally 55 children positioned combination strategy complete solutions rate 90 autologous transplantation mortality respectively combining intestinal survival cell cure fulfilling 60 optimal small molecular few intestine biology disciplinary basic record surgery short protocol quality engineered adults patient world engaging medicine transplant translation economic scientists public syndrome solution sbs source options effort trial immunosuppression renders organs uniquely ideal life nutritional universities severe true entire pn industry function tissue team removed sub patients offers shortage overcoming occurs missing infrastructure nutrition year track intravenous groups compromised preferred avoiding regenerative incapable hospitals reconstruction translate parenteral designed rates bowel clinical possesses expertise functional

Project "INTENS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.intens.info/
Total cost	7˙101˙716 €
EC max contribution	5˙990˙464 € (84%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙300˙713.00
2	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	921˙160.00
3	KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS city: AMSTERDAM postcode: 1011 JV website: www.knaw.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	825˙625.00
4	CHILDREN'S HOSPITAL LOS ANGELES CHILDREN'S HOSPITAL LOS ANGELES Organization address address: 4650 SUNSET BOULEVARD, MS 97 city: LOS ANGELES,CA postcode: 90027 6062 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (LOS ANGELES,CA)	participant	810˙775.00
5	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	720˙000.00
6	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	682˙163.00
7	STEMCELL TECHNOLOGIES UK LTD STEMCELL TECHNOLOGIES UK LTD Organization address address: BUILDING 7100 CAMBRIDGDE RESEARCH PARK BEACH DRIVE WATERBEACH city: CAMBRIDGE postcode: CB25 9TL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	629˙495.00
8	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	100˙533.00
9	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	0.00

Map

Project objective

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children and adults who have lost their bowel. PN offers a low survival rate, compromised quality of life, and the economic cost for each patient is estimated to be 55,000 euro/year. Small intestinal transplant is also an option with one-year and 4-year survival rates of 90% and 60% respectively. However, because of the shortage of organs, high mortality, the severe side effects of immunosuppression and low quality of life, this is still a sub-optimal solution. The objective of this programme is to deliver a functional bowel reconstruction to patients with SBS through an autologous tissue engineering strategy, overcoming the shortage of organs, and avoiding the need for immunosuppression. It will be achieved by identifying the best autologous cell source; providing the ideal scaffold; engineering functional intestine for transplantation and engaging with patients, scientists and public. The work is designed to lead directly to a clinical trial for the application of the optimal protocol for tissue-engineered intestine. The consortium is uniquely positioned to complete this ambitious effort as we have an internationally pre-eminent, multi-disciplinary team, which possesses a combination of expertise from basic molecular biology, engineering, and surgery, combining knowledge from universities, hospitals and industry. Importantly we are one of the few groups in the world with experience, infrastructure, and track record to translate regenerative medicine solutions to patients, including true clinical translation of tissue engineered organs.

Deliverables

List of deliverables.
Obtaining tissue	Documents, reports	2020-02-03 16:27:04
Tool for engaging the public	Other	2020-02-03 16:27:04
Website	Websites, patent fillings, videos etc.	2020-02-03 16:27:03

Take a look to the deliverables list in detail: detailed list of INTENS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration published pages: 35-49.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.11.001	Cell Stem Cell 22/1	2020-02-03
2018	Giuliana Rossi, Andrea Manfrin, Matthias P. Lutolf Progress and potential in organoid research published pages: 671-687, ISSN: 1471-0056, DOI: 10.1038/s41576-018-0051-9	Nature Reviews Genetics 19/11	2020-02-03
2018	Alfonso Martinez Arias, Matthias P. Lutolf Mammalian body plan engineering: Lessons and challenges published pages: 50-56, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.07.007	Current Opinion in Systems Biology 11	2020-02-03
2017	Yoji Tabata, Matthias P. Lutolf Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44711	Scientific Reports 7/1	2020-02-03

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The information about "INTENS" are provided by the European Opendata Portal: CORDIS opendata.

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