Explore the words cloud of the INTENS project. It provides you a very rough idea of what is the project "INTENS" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||7˙101˙716 €|
|EC max contribution||5˙990˙464 € (84%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2016-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||1˙300˙713.00|
|2||KOBENHAVNS UNIVERSITET||DK (KOBENHAVN)||participant||921˙160.00|
|3||KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW||NL (AMSTERDAM)||participant||825˙625.00|
|4||CHILDREN'S HOSPITAL LOS ANGELES||US (LOS ANGELES,CA)||participant||810˙775.00|
|5||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||participant||720˙000.00|
|6||THE FRANCIS CRICK INSTITUTE LIMITED||UK (LONDON)||participant||682˙163.00|
|7||STEMCELL TECHNOLOGIES UK LTD||UK (CAMBRIDGE)||participant||629˙495.00|
|8||THE UNIVERSITY OF EDINBURGH||UK (EDINBURGH)||participant||100˙533.00|
|9||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||participant||0.00|
Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children and adults who have lost their bowel. PN offers a low survival rate, compromised quality of life, and the economic cost for each patient is estimated to be 55,000 euro/year. Small intestinal transplant is also an option with one-year and 4-year survival rates of 90% and 60% respectively. However, because of the shortage of organs, high mortality, the severe side effects of immunosuppression and low quality of life, this is still a sub-optimal solution. The objective of this programme is to deliver a functional bowel reconstruction to patients with SBS through an autologous tissue engineering strategy, overcoming the shortage of organs, and avoiding the need for immunosuppression. It will be achieved by identifying the best autologous cell source; providing the ideal scaffold; engineering functional intestine for transplantation and engaging with patients, scientists and public. The work is designed to lead directly to a clinical trial for the application of the optimal protocol for tissue-engineered intestine. The consortium is uniquely positioned to complete this ambitious effort as we have an internationally pre-eminent, multi-disciplinary team, which possesses a combination of expertise from basic molecular biology, engineering, and surgery, combining knowledge from universities, hospitals and industry. Importantly we are one of the few groups in the world with experience, infrastructure, and track record to translate regenerative medicine solutions to patients, including true clinical translation of tissue engineered organs.
|Obtaining tissue||Documents, reports||2020-02-03 16:27:04|
|Tool for engaging the public||Other||2020-02-03 16:27:04|
|Website||Websites, patent fillings, videos etc.||2020-02-03 16:27:03|
Take a look to the deliverables list in detail: detailed list of INTENS deliverables.
|year||authors and title||journal||last update|
Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
published pages: 35-49.e7, ISSN: 1934-5909, DOI: 10.1016/j.stem.2017.11.001
|Cell Stem Cell 22/1||2020-02-03|
Giuliana Rossi, Andrea Manfrin, Matthias P. Lutolf
Progress and potential in organoid research
published pages: 671-687, ISSN: 1471-0056, DOI: 10.1038/s41576-018-0051-9
|Nature Reviews Genetics 19/11||2020-02-03|
Alfonso Martinez Arias, Matthias P. Lutolf
Mammalian body plan engineering: Lessons and challenges
published pages: 50-56, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.07.007
|Current Opinion in Systems Biology 11||2020-02-03|
Yoji Tabata, Matthias P. Lutolf
Multiscale microenvironmental perturbation of pluripotent stem cell fate and self-organization
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep44711
|Scientific Reports 7/1||2020-02-03|
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The information about "INTENS" are provided by the European Opendata Portal: CORDIS opendata.
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