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EPIROSE SIGNED

Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development

Total Cost €

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EC-Contrib. €

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Partnership

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 EPIROSE project word cloud

Explore the words cloud of the EPIROSE project. It provides you a very rough idea of what is the project "EPIROSE" about.

pathological    determinants    medicine    mechanisms    explore    outside    mysterious    events    induce    causes    architectural    cells    event    genetic    stem    genetically    shed    reveal    limitations    regenerative    axes    embryonic    initiated    human    lacking    successive    morphogenesis    dimensional    implanting    engineered    tissue    fill    screening    functional    provides    transcriptional    emergence    cellular    embryos    transformation    inaccessibility    single    culture    despite    layers    sequencing    spatio    created    photon    mother    outstanding    germ    implantation    microscopy    plan    vivo    congenital    signaling    pregnancy    global    lineage    intertwine    recapitulate    specification    tremendous    molecular    developmental    lethality    merged    post    overcome    interactions    fundamental    embryo    cell    modeling    employed    body    extrapolation    transformations    disorders    integrate    progresses    combining    light    fate    stage    mouse    morphogenetic    temporal    opportunity    gap    decisions    stages    mammalian    intricate    content   

Project "EPIROSE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://zernickagoetzlab.pdn.cam.ac.uk/research.html
 Total cost 2˙477˙951 €
 EC max contribution 2˙477˙951 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙477˙951.00

Map

 Project objective

Embryonic development progresses through successive cell fate decisions and intricate three-dimensional morphogenetic transformations. Implantation is the defining event in mammalian pregnancy during which a fundamental morphogenetic transformation is initiated: the body axes are established and the embryonic germ layers created. Despite its importance, a comprehensive understanding of the molecular mechanisms, transcriptional pathways, cellular interactions, as well as the spatio-temporal development of the embryo at implantation stages is at present lacking, due to the embryo’s inaccessibility. To overcome these limitations, we generated a culture system that allows the development of mouse implanting embryos outside of the mother. This system provides the opportunity to address how architectural features and signaling events integrate to induce the emergence of the body plan. Combining this new technology with the analysis of genetically engineered mouse embryos, the aim of this research proposal is to fill the knowledge gap between pre and post-implantation development. Single cell sequencing, two-photon microscopy, high-content forward genetic screening, and modeling will be merged with a functional assessment of embryo development in vivo to reveal the determinants of implantation and early post-implantation development. This global understanding will be employed to explore the extent to which stem cells can recapitulate embryonic development, with tremendous potential for regenerative medicine. Knowledge of the cellular and molecular mechanisms that intertwine lineage specification, developmental potential, and tissue morphogenesis will offer novel insight on the pathological causes of embryo lethality and congenital disorders. The proposed studies will shed light on this crucial yet mysterious stage of development in the mouse and, by extrapolation, offer outstanding potential to advance our understanding of human development.

 Publications

year authors and title journal last update
List of publications.
2018 Marta N. Shahbazi, Magdalena Zernicka-Goetz
Deconstructing and reconstructing the mouse and human early embryo
published pages: 878-887, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0144-x
Nature Cell Biology 20/8 2020-01-23
2018 Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells
published pages: 1586-1602, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0005-x
Nature Protocols 13/7 2020-01-23
2017 Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni, Magdalena Zernicka-Goetz
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24675
Nature 2020-01-23
2018 Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M. Glover, Magdalena Zernicka-Goetz
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
published pages: 979-989, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0147-7
Nature Cell Biology 20/8 2020-01-23

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