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EPIROSE SIGNED

Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development

Total Cost €

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EC-Contrib. €

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Partnership

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 EPIROSE project word cloud

Explore the words cloud of the EPIROSE project. It provides you a very rough idea of what is the project "EPIROSE" about.

body    genetically    photon    stem    cell    disorders    medicine    signaling    emergence    modeling    culture    plan    mechanisms    merged    morphogenetic    embryos    layers    intricate    mother    provides    content    temporal    events    molecular    regenerative    tremendous    opportunity    specification    embryo    post    vivo    initiated    explore    spatio    shed    lineage    implanting    morphogenesis    mysterious    developmental    fundamental    limitations    event    extrapolation    fill    pregnancy    light    transformations    determinants    gap    genetic    induce    engineered    congenital    germ    outside    reveal    mammalian    axes    dimensional    successive    embryonic    inaccessibility    human    single    employed    pathological    global    functional    stages    causes    microscopy    progresses    architectural    created    fate    implantation    combining    decisions    despite    transformation    interactions    stage    outstanding    recapitulate    cellular    lacking    overcome    screening    mouse    sequencing    intertwine    transcriptional    tissue    cells    lethality    integrate   

Project "EPIROSE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://zernickagoetzlab.pdn.cam.ac.uk/research.html
 Total cost 2˙477˙951 €
 EC max contribution 2˙477˙951 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙477˙951.00

Map

 Project objective

Embryonic development progresses through successive cell fate decisions and intricate three-dimensional morphogenetic transformations. Implantation is the defining event in mammalian pregnancy during which a fundamental morphogenetic transformation is initiated: the body axes are established and the embryonic germ layers created. Despite its importance, a comprehensive understanding of the molecular mechanisms, transcriptional pathways, cellular interactions, as well as the spatio-temporal development of the embryo at implantation stages is at present lacking, due to the embryo’s inaccessibility. To overcome these limitations, we generated a culture system that allows the development of mouse implanting embryos outside of the mother. This system provides the opportunity to address how architectural features and signaling events integrate to induce the emergence of the body plan. Combining this new technology with the analysis of genetically engineered mouse embryos, the aim of this research proposal is to fill the knowledge gap between pre and post-implantation development. Single cell sequencing, two-photon microscopy, high-content forward genetic screening, and modeling will be merged with a functional assessment of embryo development in vivo to reveal the determinants of implantation and early post-implantation development. This global understanding will be employed to explore the extent to which stem cells can recapitulate embryonic development, with tremendous potential for regenerative medicine. Knowledge of the cellular and molecular mechanisms that intertwine lineage specification, developmental potential, and tissue morphogenesis will offer novel insight on the pathological causes of embryo lethality and congenital disorders. The proposed studies will shed light on this crucial yet mysterious stage of development in the mouse and, by extrapolation, offer outstanding potential to advance our understanding of human development.

 Publications

year authors and title journal last update
List of publications.
2018 Marta N. Shahbazi, Magdalena Zernicka-Goetz
Deconstructing and reconstructing the mouse and human early embryo
published pages: 878-887, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0144-x
Nature Cell Biology 20/8 2020-01-23
2018 Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells
published pages: 1586-1602, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0005-x
Nature Protocols 13/7 2020-01-23
2017 Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni, Magdalena Zernicka-Goetz
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24675
Nature 2020-01-23
2018 Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M. Glover, Magdalena Zernicka-Goetz
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
published pages: 979-989, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0147-7
Nature Cell Biology 20/8 2020-01-23

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