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LUCA SIGNED

Laser and Ultrasound Co-Analyzer for thyroid nodules

Total Cost €

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EC-Contrib. €

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Partnership

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 LUCA project word cloud

Explore the words cloud of the LUCA project. It provides you a very rough idea of what is the project "LUCA" about.

limited    euros    trs    thyroidectomies    followed    fails    specificity    comorbidities    joins    suspicious    savings    device    sub    spectroscopy    enabled    biopsy    modality    modal    correlation    exclude    care    photonic    photonics    components    participate    radiologists    women    fnab    screening    diffuse    surgeries    infrared    experts    procedure    industrial    15    industry    dcs    resolved    time    sensitivity    76    synergetic    near    cover    men    medical    action    combines    nodules       diagnostic    acquisition    ultrasound    function    thyroid    palpable    physicists    unnecessary    composition    shows    diminishing    positive    disciplinary    implies    occurs    hypothesize    exploited    fine    pathology    chain    tc    tn    point    socio       first    engineers    economic    hemodynamic    leads    tissue    data    ultrasonics    needle    prevalence    morphology    neck    false    directed    endocrinologists    19    probe    trans    concentrated    millions    optical    aspiration    cancer   

Project "LUCA" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES 

Organization address
address: AVINGUDA CARL FRIEDRICH GAUSS 3
city: Castelldefels
postcode: 8860
website: www.icfo.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.luca-project.eu/
 Total cost 3˙999˙334 €
 EC max contribution 3˙628˙845 € (91%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2015
 Funding Scheme IA
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) coordinator 1˙048˙730.00
2    POLITECNICO DI MILANO IT (MILANO) participant 689˙700.00
3    HEMOPHOTONICS SL ES (CASTELLDEFELS) participant 402˙299.00
4    EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG AT (WIEN) participant 375˙000.00
5    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 353˙763.00
6    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 297˙178.00
7    IMV IMAGING FRANCE FR (ANGOULEME) participant 273˙542.00
8    VERMON SA FR (TOURS) participant 188˙630.00

Map

 Project objective

This is a trans-disciplinary project that joins endocrinologists (“end-users”), radiologists (“end-users”), physicists who are experts in medical photonics, engineers who are experts in photonics and ultrasonics and the industry to work towards a concentrated goal - to produce a novel, point-of-care, low-cost, screening device that combines two photonics systems (near-infrared diffuse correlation spectroscopy (DCS) and time-resolved spectroscopy (TRS)) with a multi-modal ultrasound (US) system and a probe that enables multi-modal data acquisition for the screening of thyroid nodules (TN) for thyroid cancer (TC). TN are a common pathology having a prevalence of palpable nodules around 5% in women and 1% in men, that increases to 19-76% with the use of neck US. In screening thyroid nodules, to exclude thyroid cancer which occurs in 5-15% of TN, the first step is the US followed by fine needle aspiration biopsy (FNAB) of suspicious nodules. The sensitivity and specificity of this process in thyroid cancer are limited, with a large number of non-diagnostic and false positive results that lead to unnecessary surgeries. A reduction in the number of surgeries with a point-of-care diagnostic procedure would have an important socio-economic impact, diminishing the number of thyroidectomies and the associated comorbidities. This implies savings of millions of euros per year. Evidence shows that multi-modal approaches that include hemodynamic information leads to better specificity while each modality on its own fails. We hypothesize that a new optical-ultrasound probe and integrated system enabled by the development of novel, key enabling photonic components and sub-systems to provide synergetic information on tissue morphology, composition and function will have a large impact in this field. Our action is directed by end-users who participate in the proposal and will be exploited by the industrial partners who cover the whole value-chain.

 Deliverables

List of deliverables.
Communication kit update Documents, reports 2020-02-28 09:35:32
Report on the dissemination activity Y2 Documents, reports 2020-02-28 09:35:32
Fully functional LUCA system Demonstrators, pilots, prototypes 2020-02-28 09:35:32
Report on the dissemination activity Y3 Documents, reports 2020-02-28 09:35:32
Data Management Plan_new Open Research Data Pilot 2020-02-28 09:35:32
Approval by ethical committees Documents, reports 2020-02-28 09:35:32
Project web site Websites, patent fillings, videos etc. 2020-02-28 09:35:31
Provision of a optical-ultrasound phantom kit Demonstrators, pilots, prototypes 2020-02-28 09:35:30
Dissemination material Websites, patent fillings, videos etc. 2020-02-28 09:35:30
Project management and quality assurance plan Documents, reports 2020-02-28 09:35:30
Project Presentation Documents, reports 2020-02-28 09:35:31
Dissemination and communication plan Documents, reports 2020-02-28 09:35:31
Data Management Plan Documents, reports 2020-02-28 09:35:32
Report on the dissemination activity Y1 Documents, reports 2020-02-28 09:35:31
Video Websites, patent fillings, videos etc. 2020-02-28 09:35:31

Take a look to the deliverables list in detail:  detailed list of LUCA deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi
Eight-Wavelength, Dual Detection Channel Instrument for Near-Infrared Time-Resolved Diffuse Optical Spectroscopy
published pages: 1-11, ISSN: 1077-260X, DOI: 10.1109/jstqe.2018.2863570
IEEE Journal of Selected Topics in Quantum Electronics 25/1 2020-02-28
2018 Lorenzo Cortese, Giuseppe Lo Presti, Marco Pagliazzi, Davide Contini, Alberto Dalla Mora, Antonio Pifferi, Sanathana Konugolu Venkata Sekar, Lorenzo Spinelli, Paola Taroni, Marta Zanoletti, Udo M. Weigel, Sixte de Fraguier, An Nguyen-Dihn, Bogdan Rosinski, Turgut Durduran
Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties
published pages: 2068, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002068
Biomedical Optics Express 9/5 2020-02-28
2018 Stanislaw Wojtkiewicz, Turgut Durduran, Hamid Dehghani
Time-resolved near infrared light propagation using frequency domain superposition
published pages: 41, ISSN: 2156-7085, DOI: 10.1364/boe.9.000041
Biomedical Optics Express 9/1 2020-02-28
2018 Sanathana Konugolu Venkata Sekar, Andrea Farina, Alberto Dalla Mora, Claus Lindner, Marco Pagliazzi, Mireia Mora, Gloria Aranda, Hamid Dehghani, Turgut Durduran, Paola Taroni, Antonio Pifferi
Broadband (550–1350 nm) diffuse optical characterization of thyroid chromophores
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-27684-8
Scientific Reports 8/1 2020-02-28
2017 Mauro Buttafava, Edoardo Martinenghi, Davide Tamborini, Davide Contini, Alberto Dalla Mora, Marco Renna, Alessandro Torricelli, Antonio Pifferi, Franco Zappa, Alberto Tosi
A Compact Two-Wavelength Time-Domain NIRS System Based on SiPM and Pulsed Diode Lasers
published pages: 1-14, ISSN: 1943-0655, DOI: 10.1109/JPHOT.2016.2632061
IEEE Photonics Journal 9/1 2020-02-28
2016 E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, A. Dalla Mora
Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems
published pages: 73101, ISSN: 0034-6748, DOI: 10.1063/1.4954968
Review of Scientific Instruments 87/7 2020-02-28

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