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NANO-SUPREMI SIGNED

“Tracking nano-bioprocesses using Super-Resolution Microscopy Techniques”

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANO-SUPREMI project word cloud

Explore the words cloud of the NANO-SUPREMI project. It provides you a very rough idea of what is the project "NANO-SUPREMI" about.

collaborations manufacturers innovative cellular plugging nano goals microscope setting bio interdisciplinary answer full scientific gap nanoscale ideas efficacy structures dna creative trafficking outstanding analytical record vitro explore drive junior careers questions ranging clinical complementary intersectoral membrane education solving evaluation potentiality single international science supremi stage synergistic therapeutic nanomedicines countries long techniques turn probe resolution protein interactions biological achievements participation nanometer ultimately transformative synthetic molecular bioprocesses dynamic super achievement materials nanophotonics biomedical settled biology au groups microscopy pursued chemistry brazil services cu fundamental innovation molecule dimension few tracking technologies

Project "NANO-SUPREMI" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Organization address address: VIA CRACOVIA 50 city: ROMA postcode: 133 website: www.uniroma2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://nanosupremi.fnusa-icrc.org.
Total cost	873˙000 €
EC max contribution	724˙500 € (83%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Organization address address: VIA CRACOVIA 50 city: ROMA postcode: 133 website: www.uniroma2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	306˙000.00
2	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	270˙000.00
3	FAKULTNI NEMOCNICE U SV. ANNY V BRNE FAKULTNI NEMOCNICE U SV. ANNY V BRNE Organization address address: Pekarska 53 city: Brno postcode: 656 91 website: www.fnusa.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (Brno)	participant	148˙500.00
4	FUNDACAO UNIVERSIDADE FEDERAL DO ABC FUNDACAO UNIVERSIDADE FEDERAL DO ABC Organization address address: RUA SANTA ADELIA 166 city: SANTO ANDRE postcode: 09 210 170 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (SANTO ANDRE)	partner	0.00
5	Ministerio de Ciencia, Tecnología y Medio Ambiente Ministerio de Ciencia, Tecnología y Medio Ambiente Organization address address: Capitolio 10 200 city: La Habana postcode: n.a. website: www.citmahabana.cu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CU (La Habana)	partner	0.00
6	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	partner	0.00
7	UNIVERSITY OF MELBOURNE UNIVERSITY OF MELBOURNE Organization address address: PARKVILLEOFFICE OF THE VICE CHANCELLOR city: MELBOURNE postcode: 3010 website: www.unimelb.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (MELBOURNE)	partner	0.00

Map

Project objective

Long-range research and innovation goal: The long-range goal of Nano-Supremi is to develop case studies to enable the advanced super-resolution microscopy to investigate nanoscale synthetic and biological structures and to probe nanoscale dynamic processes. Long-range biomedical research and technology goal: The implementation of Nano-Supremi will allow for tracking nanometer-scale bioprocesses such as (i) nanomedicines cellular uptake and trafficking and (ii) single-molecule dynamic processes of DNA-protein, (iii) protein-membrane interactions. Key Research Goals: The objective of Nano-Supremi is to turn the following creative research ideas into advanced microscopy technologies and services. This will ultimately results in the evaluation of in vitro protein and DNA activity and therapeutic efficacy of nanomedicines plugging the gap between innovative research and its exploitation in clinical setting. Scientific impact: We identified a few innovative case studies to explore the potentiality of super resolution microscopy techniques in solving nanoscale bio-structures and dynamic processes. Impact on early-stage researchers: Nano-Supremi involves key participation of junior researchers with outstanding record of achievements in education and research, providing strong support for the development of their careers. Intersectoral dimension: A synergistic approach in using advanced technologies developed by microscope manufacturers to answer fundamental and applied questions on bioprocesses will be pursued. Interdisciplinary dimension: A complementary research program, ranging from nanophotonics, materials science, to molecular biology and bio-analytical chemistry, will drive the implementation of research tasks towards the full achievement of the objectives. International dimension: Funding of this program will enable long-term, transformative research collaborations between groups settled in European Countries and in four non-EU Countries (AU, US, Brazil, Cu)

Deliverables

List of deliverables.
Proceedings and teaching material concerning EU grants	Documents, reports	2020-03-11 13:05:38
Submitted grant proposals to European Community, NSF and NIH (USA), ARC	Documents, reports	2020-03-11 13:05:35
Lecture notes on advanced microscopy methods and technologies	Documents, reports	2020-03-11 13:05:34
Lecture notes and conference presentations	Documents, reports	2019-10-08 17:07:18
Training young scientist on experimental methods for studying YAP protein and protein mechanosensor; Training young scientist on experimental advanced microscopy-AFM techniques	Other	2019-09-02 14:28:37
\"Lecture notes on \"\"Role of mechanotransduction systems during stem cell differentiation\"\" and â€œ Advanced microscopy for protein trackingâ€\"	Documents, reports	2019-09-02 14:28:37
Serve as a training platform providing courses, individual instruction, and consulting on STED, STORM, SIM, FCS-STED and FLIM	Other	2019-09-02 14:28:37
A set of DNA-based fluorescent TF-beacons for TEAD and NF-kB inhibition; Characterization of TEAD/YAP behaviour during mammary cancer progression	Documents, reports	2019-09-02 14:28:37
Curriculum of interdisciplinary studies on innovation strategies	Documents, reports	2019-09-02 14:28:37
Training young scientist on the use of STED, STORM, SIM, FCS-STED and FLIM	Other	2019-09-02 14:28:36
Training young scientist on experimental methods for nanobubbles and nanogels preparation; Training young scientist on experimental methods for studying the physico-chemical properties of siRNA loaded nanocarriers	Other	2019-09-02 14:28:37
Support research giving access to most advanced technologies in the field of cellular imaging, data analysis and image processing available at IIT and Nikon Imaging Centre (NIC@IIT)	Other	2019-09-02 14:28:36
Minute conference calls for coordination of visiting periods	Documents, reports	2019-09-02 14:28:36
\"Lecture notes on \"\"Role of mechanotransduction systems during stem cell differentiation\"\"\"	Other	2019-09-02 14:28:36
Training ESR on experimental methods for studying the behaviour of DNA-based conformational switching probes in solution; Training ESR on experimental methods for engineering and characterization of nanocarriers	Other	2019-09-02 14:28:36
Training young scientist on biochemistry and molecular biology methods in the laboratory; Training young scientist on experimental methods for studying YAP/TEAD and NFkB	Other	2019-09-02 14:28:36
Seminars held at industries and SME	Other	2019-09-02 14:28:36
Definition of the best conditions to obtain and enrich iPSCs lines expressing YAP-GFP construct and its mutants; Definition of the domains of YAP protein responsible for its acknowledged mechanosensor activity	Documents, reports	2019-09-02 14:28:36
Complete the synthesis and characterization of siRNA-loaded nanobubble and nanogels	Documents, reports	2019-09-02 14:28:36

Take a look to the deliverables list in detail: detailed list of NANO-SUPREMI deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Sukhvir Kaur Bhangu, Gianfranco Bocchinfuso, Muthupandian Ashokkumar, Francesca Cavalieri Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles published pages: , ISSN: 2055-6756, DOI: 10.1039/c9nh00611g	Nanoscale Horizons	2020-03-05
2020	Rita Cimino, Elisa Grelloni, Gabriele Magna, Donato Monti, Manuela Stefanelli, Emanuela Gatto, Ernesto Placidi, Francesca Biscaglia, Marina Gobbo, Mariano Venanzi Tuning the morphology of mesoscopic structures of porphyrin macrocycles functionalized by an antimicrobial peptide published pages: A-I, ISSN: 1088-4246, DOI: 10.1142/s1088424619502006	Journal of Porphyrins and Phthalocyanines	2020-03-05
2019	Marta De Zotti, Gabriele Corvi, Emanuela Gatto, Benedetta Di Napoli, Claudia Mazzuca, Antonio Palleschi, Ernesto Placidi, Barbara Biondi, Marco Crisma, Fernando Formaggio, Claudio Toniolo, Mariano Venanzi Controlling the Formation of Peptide Films: Fully Developed Helical Peptides are Required to Obtain a Homogenous Coating over a Large Area published pages: 1688-1696, ISSN: 2192-6506, DOI: 10.1002/cplu.201900456	ChemPlusChem 84/11	2020-03-05
2019	Barbara B. Gerbelli, Sandra V. Vassiliades, Jose E. U. Rojas, Juliane N. B. D. Pelin, Rodrigo S. N. Mancini, Wallace S. G. Pereira, Andrea M. Aguilar, Mariano Venanzi, Francesca Cavalieri, Francesca Giuntini, Wendel A. Alves Hierarchical Selfâ€Assembly of Peptides and its Applications in Bionanotechnology published pages: 1900085, ISSN: 1022-1352, DOI: 10.1002/macp.201900085	Macromolecular Chemistry and Physics 220/14	2020-03-05
2018	Marta De Zotti, Beatrice Muzzi, Emanuela Gatto, Benedetta Di Napoli, Claudia Mazzuca, Antonio Palleschi, Ernesto Placidi, Fernando Formaggio, Claudio Toniolo, Mariano Venanzi Tuning the Morphology of Nanostructured Peptide Films by the Introduction of a Secondary Structure Conformational Constraint: A Case Study of Hierarchical Self-Assembly published pages: 6305-6313, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.8b01877	The Journal of Physical Chemistry B 122/24	2019-10-09
2018	Juliane N. B. D. Pelin, Emanuela Gatto, Mariano Venanzi, Francesca Cavalieri, Cristiano L. P. Oliveira, Herculano Martinho, Emerson R. Silva, Andrea M. Aguilar, Juliana S. Souza, Wendel A. Alves Hybrid Conjugates Formed between Gold Nanoparticles and an Amyloidogenic Diphenylalanine-Cysteine Peptide published pages: 6756-6765, ISSN: 2365-6549, DOI: 10.1002/slct.201801345	ChemistrySelect 3/24	2019-10-09

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