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BIOACTIVECOATINGS

BioActive Coatings in multi-well cell culture plates

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BIOACTIVECOATINGS project word cloud

Explore the words cloud of the BIOACTIVECOATINGS project. It provides you a very rough idea of what is the project "BIOACTIVECOATINGS" about.

cellular    vitro    mechanical    market    extra    biochemical    lbl    assembly    functions    biopolymers    material    surface    biological    trigger    molecules    dishes    discovery    coatings    petri    cell    presentation    synthetic    medicine    date    artificially    drug    plates    soft    alternatives    provides    generally    polystyrene    industry    innovative    layer    hydrogels    biotechnologies    environment    microscopy    substrates    regenerative    stiffness    drastically    broaden    optical    physiological    microenvironment    signals    experimental    assays    hydration    stability    bioengineers    coated    commercially    vivo    performed    peptide    biomolecules    outside    diagnosis    surrounded    active    cells    thickness    few    hydrogel    mimic    natural    fundamental    bias    lack    time    receptors    living    sensitive    compatible    plastic    bioactivecoatings    throughput    mask    substrate    ecm    made    strategy    bioactive    contrast    stiff    peptides    matrix    begun    culture   

Project "BIOACTIVECOATINGS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT POLYTECHNIQUE DE GRENOBLE 

Organization address
address: AVENUE FELIX VIALLET 46
city: GRENOBLE CEDEX 1
postcode: 38031
website: http://www.grenoble-inp.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 149˙998 €
 EC max contribution 149˙998 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT POLYTECHNIQUE DE GRENOBLE FR (GRENOBLE CEDEX 1) coordinator 149˙998.00

Map

 Project objective

Cell culture is a method used for growing living cells artificially outside their natural environment under controlled conditions. It is used for a large range of applications such as studies of cellular functions, drug discovery, biotechnologies and regenerative medicine. Cell culture in vitro is generally performed on plastic substrates, especially multi-well plates or Petri dishes that are made of polystyrene, a very stiff and synthetic material. This stiff substrate can bias the experimental results and mask cellular responses. These culture conditions contrast drastically with the conditions of the cellular microenvironment in vivo, where the cells are surrounded by a soft extra-cellular matrix (ECM) that provides mechanical and biochemical signals. Bioengineers have recently made developments on hydrogels and surface coatings that better mimic the natural ECM and present: 1) a controlled stiffness in a more physiological range than plastic dishes and 2) active biomolecules (peptides, growth factors) that can target specific receptors and trigger cellular responses. However, to date, there are still very few commercially available alternatives to the traditional plastic plates for high throughput cell culture in more relevant conditions. Hydrogel-coated plates have begun to be developed but lack stability in time and are highly sensitive to hydration. The aim of the BioActiveCoatings project is to bring to the market surface-coated plates with a control over thickness, stiffness and presentation of bioactive molecules (peptide, growth factor). This innovative strategy based on the layer-by-layer assembly of biopolymers will be implemented on multi-well plates, which are compatible with biological assays and optical microscopy. The Lbl-coated multi-well plates will broaden the application of cell culture plates in research and industry for fundamental biological studies, production of biological molecules, diagnosis and regenerative medicine.

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The information about "BIOACTIVECOATINGS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-24 8:59:42) correctly updated