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NeurOLED SIGNED

Organic Light-Emitting Diodes for Optogenetic Control of Neurons

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NeurOLED" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS 

Organization address
address: NORTH STREET 66 COLLEGE GATE
city: ST ANDREWS
postcode: KY16 9AJ
website: www.st-andrews.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://gatherlab.wp.st-andrews.ac.uk/people/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS UK (ST ANDREWS) coordinator 195˙454.00

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 Project objective

Optogenetics is an emerging new method in biology for the non-invasive control of neuronal behaviour with light. NeurOLED will develop and validate a novel, biocompatible light source that provides unprecedented high-resolution, real-time optogenetic control of neurons. At the heart of the new devices are organic light-emitting diodes (OLEDs) that are brought into direct contact with neuronal cells. Using microscopic patterning, we will create dense arrays of OLEDs that can stimulate the firing of individual live neurons. Initial proof-of-principle experiments will use the new OLED light source to study neuronal networks in vitro. To fully exploit the potential of OLEDs in optogenetics, neuronal networks will ultimately be investigated in vivo. We will examine the neuronal network that is responsible for locomotion in the model organism Drosophila melanogaster. To maximize spatial resolution in vivo, the light penetration depth in tissue will be optimized by systematic optical design of the spectral and angular emission characteristics of the OLEDs. Furthermore, stacked multi-colour OLEDs will be used to achieve both activation and deactivation of single neurons at very high speed and precision. Atomic layer deposition will be used as an innovative thin-film encapsulation technology to develop OLEDs that can withstand aqueous environments and can thus be brought into direct contact with neurons and biological tissue. Compared to current state-of-the-art optogenetic light sources, OLEDs will significantly advance control of neuronal behaviour thus paving the way to a better understanding of neural networks.

 Publications

year authors and title journal last update
List of publications.
2016 Andrew Morton, Caroline Murawski, Stefan R. Pulver, Malte C. Gather
High-brightness organic light-emitting diodes for optogenetic control of Drosophila locomotor behaviour
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31117
Scientific Reports 6/1 2019-06-13
2018 Caroline Murawski, Chris Elschner, Simone Lenk, Sebastian Reineke, Malte C. Gather
Investigating the molecular orientation of Ir(ppy) 3 and Ir(ppy) 2 (acac) emitter complexes by X-ray diffraction
published pages: 198-204, ISSN: 1566-1199, DOI: 10.1016/j.orgel.2017.11.036
Organic Electronics 53 2019-06-13
2018 Arko Graf, Caroline Murawski, Yuriy Zakharko, Jana Zaumseil, Malte C. Gather
Infrared Organic Light-Emitting Diodes with Carbon Nanotube Emitters
published pages: 1706711, ISSN: 0935-9648, DOI: 10.1002/adma.201706711
Advanced Materials 30/12 2019-06-13
2018 Chang-Min Keum, Nils M. Kronenberg, Caroline Murawski, Kou Yoshida, Yali Deng, Cordelia Berz, Wenbo Li, Mengjie Wei, Ifor D. W. Samuel, Malte C. Gather
The Role of Metallic Dopants in Improving the Thermal Stability of the Electron Transport Layer in Organic Light-Emitting Diodes
published pages: 1800496, ISSN: 2195-1071, DOI: 10.1002/adom.201800496
Advanced Optical Materials 2019-06-13

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