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APTASENS

A new generation of AptaSensors

Total Cost €

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EC-Contrib. €

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Partnership

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Project "APTASENS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://sites.google.com/view/aptasens/home
 Total cost 239˙191 €
 EC max contribution 239˙191 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 239˙191.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

The aim of this project is to design different next generation libraries of biosensors that will yield ready-to-go analytical tools against any target in unprecedented speed and high affinity. The project intends to focus on aptamers, a new generation of recognition elements that will be integrated into bioelectronics devices. The huge number of candidates to be tested using a combinatorial trial and error approach will be radically reduced by rationalizing the strategy to design the aptamers. A new virtual screening process will be used for the generation of aptamers by the help of modern molecular modelling tools. The design and binding of large database will be created and screened by adding or mutating molecule bricks (amino acids and DNA), minimizing experimental tests and therefore reducing the research costs. These sensor elements will be organized in medium to high density nucleic acid and peptide arrays with different transducing principles. In particular, we will design and produce an electrochemical sensor array platform based on screen printing technology together with suitable extraction- and pre-concentration procedures by coupling aptamers to nanoparticles. The analytical procedures produced will be tested using first standards and then real samples. The target molecules will be analytes related to health and safety control (Xenobiotics: e.g. PCB, pesticides. Mycotoxins: e.g. patulin, nivalenol, Antioxidants: e.g. resveratrol, luteolin). The proposal has strong focus on development of concrete evolutionary new biosensors for application to diagnostics, food, terrorism threat agents, environmental and new frontiers analysis such as bioanalysis in the space.

 Publications

year authors and title journal last update
List of publications.
2018 Marcello Mascini, Sara Gaggiotti, Flavio Della Pelle, Joseph Wang, José M. Pingarrón, Dario Compagnone
Hairpin DNA-AuNPs as molecular binding elements for the detection of volatile organic compounds
published pages: 7, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.07.028
Biosensors and Bioelectronics 2019-09-13
2017 Esteban-Fernandez de Avila, B. Zhao, M. Campuzano, S. Ricci, F. Pingarron, J. M. Mascini, M. Wang, J.
Rapid Micromotor-Based Naked-Eye Immunoassay
published pages: , ISSN: 0039-9140, DOI: 10.1016/j.talanta.2017.02.068
TALANTA 2019-09-13
2017 Marcello Mascinia, Camilla Montesano, German Perez, Joseph Wang, Dario Compagnone, Manuel Sergi
Selective solid phase extraction of JWH synthetic cannabinoids by using computationally designed peptides
published pages: , ISSN: 0039-9140, DOI: 10.1016/j.talanta.2017.01.072
TALANTA 2019-09-13

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The information about "APTASENS" are provided by the European Opendata Portal: CORDIS opendata.

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