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PANA SIGNED

PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES.

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "PANA" data sheet

The following table provides information about the project.

Coordinator
SERVIZO GALEGO DE SAUDE 

Organization address
address: Edificio Administrativo San Lázaro
city: Santiago de Compostela
postcode: 15703
website: www.sergas.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://panaproject.eu/
 Total cost 7˙775˙972 €
 EC max contribution 7˙775˙972 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
 Code Call H2020-NMP-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SERVIZO GALEGO DE SAUDE ES (Santiago de Compostela) coordinator 1˙573˙537.00
2    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 1˙094˙875.00
3    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 1˙055˙500.00
4    BIOTECHPHARMA LT (VILNIUS) participant 845˙250.00
5    STICHTING VU NL (AMSTERDAM) participant 762˙125.00
6    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 529˙750.00
7    reMYND NV BE (LEUVEN) participant 482˙720.00
8    STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA PT (CAPARICA) participant 463˙030.00
9    FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON ES (SORIA) participant 396˙250.00
10    LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA PT (BRAGA) participant 319˙497.00
11    ROCHE DIAGNOSTICS SL ES (BARCELONA) participant 253˙437.00

Map

 Project objective

Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new effective early diagnostic and therapeutic strategies to help in delaying the appearance of the most adverse symptoms of this disease. To defeat this challenge, PANA project bases its approach on the importance of tau oligomers in the early pathophysiological processes of AD. The effective strategy will be based on two fundamental pillars; on one hand, efforts will be focused on multimodal PET/MRI imaging which is gaining relevance as the best solution for diagnostic purposes due to the complementary advantages of both technologies, combining the high structural characterization of tissue provided by MRI with the enhanced sensitivity of PET imaging. On the other hand, the challenging development of a theragnostic nanostructures will be focused on tau oligomers detection, which would have to deliver theragnostic agents into the brain to provide in situ diagnostic and therapeutic effects. Therefore, PANA project focuses on developing theranostic nanostructures that specifically recognize very-early molecular markers of AD, and can be detected by means of non-invasive imaging methodologies (MRI and/or PET, which are already common techniques accessible in most hospitals) and eventually provide a therapeutic action if needed. To achieve this goal, we propose a unique consortium which combines neuroscientists, nanotechnologists, molecular imaging experts, clinicians and Small/Medium/Large Enterprises in an effort to use smart nanoparticles engineered with multifunctional biomaterial to provide new very-early diagnostic tools for AD, a vital medical/social problem in EU.

 Deliverables

List of deliverables.
Dissemination material (version 1) Documents, reports 2020-03-11 12:30:53
Dissemination and communication plan Documents, reports 2020-03-11 12:30:53
Project web site Documents, reports 2020-03-11 12:30:53

Take a look to the deliverables list in detail:  detailed list of PANA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Adrián Posado Fernández
In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy
published pages: , ISSN: , DOI:
2020-03-11
2019 Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers
Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer\'s disease with amyloid and tau pathology
published pages: e4037, ISSN: 0952-3480, DOI: 10.1002/nbm.4037
NMR in Biomedicine 32/2 2020-03-11
2019 Zulema Vargas-Osorio, Andrés Da Silva-Candal, Yolanda Piñeiro, Ramón Iglesias-Rey, Tomas Sobrino, Francisco Campos, José Castillo, José Rivas
Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications
published pages: 449, ISSN: 2079-4991, DOI: 10.3390/nano9030449
Nanomaterials 9/3 2020-03-11
2019 Zulema Vargas-Osorio, Asteria Luzardo-Álvarez, Yolanda Piñeiro, Carlos Vázquez-Vázquez, J. Luis Gómez-Amoza, José Blanco-Méndez, Francisco J. Otero Espinar, José Rivas
Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility
published pages: 5496-5508, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b03676
ACS Omega 4/3 2020-03-11
2018 Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten
Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia
published pages: e12790, ISSN: 1474-9718, DOI: 10.1111/acel.12790
Aging Cell 17/4 2020-03-11
2018 Rita Sofia Garcia Ribeiro, Conny Gysemans, João Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel Bañobre-López, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29136-9
Scientific Reports 8/1 2020-03-11
2019 Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M.A. Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
published pages: 98-108, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.11.008
Neurobiology of Aging 75 2020-03-11

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