Explore the words cloud of the PANA project. It provides you a very rough idea of what is the project "PANA" about.
The following table provides information about the project.
SERVIZO GALEGO DE SAUDE
|Coordinator Country||Spain [ES]|
|Total cost||7˙775˙972 €|
|EC max contribution||7˙775˙972 € (100%)|
1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
|Duration (year-month-day)||from 2016-03-01 to 2021-02-28|
Take a look of project's partnership.
|1||SERVIZO GALEGO DE SAUDE||ES (Santiago de Compostela)||coordinator||1˙573˙537.00|
|2||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||1˙094˙875.00|
|3||ITA-SUOMEN YLIOPISTO||FI (KUOPIO)||participant||1˙055˙500.00|
|5||STICHTING VU||NL (AMSTERDAM)||participant||762˙125.00|
|6||UNIVERSIDAD DE SANTIAGO DE COMPOSTELA||ES (SANTIAGO DE COMPOSTELA)||participant||529˙750.00|
|7||reMYND NV||BE (LEUVEN)||participant||482˙720.00|
|8||STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA||PT (CAPARICA)||participant||463˙030.00|
|9||FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON||ES (SORIA)||participant||396˙250.00|
|10||LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA||PT (BRAGA)||participant||319˙497.00|
|11||ROCHE DIAGNOSTICS SL||ES (BARCELONA)||participant||253˙437.00|
Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy in the elderly, implying a progressive cognitive decline and limitation of social activities. Progressive aging of EU population will increase the magnitude of this problem in the next decades. Currently, there is not an effective method for the early diagnosis of AD. Therefore, there is an urgent need to develop new effective early diagnostic and therapeutic strategies to help in delaying the appearance of the most adverse symptoms of this disease. To defeat this challenge, PANA project bases its approach on the importance of tau oligomers in the early pathophysiological processes of AD. The effective strategy will be based on two fundamental pillars; on one hand, efforts will be focused on multimodal PET/MRI imaging which is gaining relevance as the best solution for diagnostic purposes due to the complementary advantages of both technologies, combining the high structural characterization of tissue provided by MRI with the enhanced sensitivity of PET imaging. On the other hand, the challenging development of a theragnostic nanostructures will be focused on tau oligomers detection, which would have to deliver theragnostic agents into the brain to provide in situ diagnostic and therapeutic effects. Therefore, PANA project focuses on developing theranostic nanostructures that specifically recognize very-early molecular markers of AD, and can be detected by means of non-invasive imaging methodologies (MRI and/or PET, which are already common techniques accessible in most hospitals) and eventually provide a therapeutic action if needed. To achieve this goal, we propose a unique consortium which combines neuroscientists, nanotechnologists, molecular imaging experts, clinicians and Small/Medium/Large Enterprises in an effort to use smart nanoparticles engineered with multifunctional biomaterial to provide new very-early diagnostic tools for AD, a vital medical/social problem in EU.
|Dissemination material (version 1)||Documents, reports||2020-03-11 12:30:53|
|Dissemination and communication plan||Documents, reports||2020-03-11 12:30:53|
|Project web site||Documents, reports||2020-03-11 12:30:53|
Take a look to the deliverables list in detail: detailed list of PANA deliverables.
|year||authors and title||journal||last update|
AdriÃ¡n Posado FernÃ¡ndez
In the Siege of AlzheimerÂ´s Castle: Contribution to Immunotherapy
published pages: , ISSN: , DOI:
Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers
Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer\'s disease with amyloid and tau pathology
published pages: e4037, ISSN: 0952-3480, DOI: 10.1002/nbm.4037
|NMR in Biomedicine 32/2||2020-03-11|
Zulema Vargas-Osorio, AndrÃ©s Da Silva-Candal, Yolanda PiÃ±eiro, RamÃ³n Iglesias-Rey, Tomas Sobrino, Francisco Campos, JosÃ© Castillo, JosÃ© Rivas
Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications
published pages: 449, ISSN: 2079-4991, DOI: 10.3390/nano9030449
Zulema Vargas-Osorio, Asteria Luzardo-Ãlvarez, Yolanda PiÃ±eiro, Carlos VÃ¡zquez-VÃ¡zquez, J. Luis GÃ³mez-Amoza, JosÃ© Blanco-MÃ©ndez, Francisco J. Otero Espinar, JosÃ© Rivas
Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility
published pages: 5496-5508, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b03676
|ACS Omega 4/3||2020-03-11|
Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten
Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia
published pages: e12790, ISSN: 1474-9718, DOI: 10.1111/acel.12790
|Aging Cell 17/4||2020-03-11|
Rita Sofia Garcia Ribeiro, Conny Gysemans, JoÃ£o Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel BaÃ±obre-LÃ³pez, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich
Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29136-9
|Scientific Reports 8/1||2020-03-11|
Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, AdriÃ¡n Posado-FernÃ¡ndez, Simo RyhÃ¤nen, Petra MÃ¤kinen, Kaisa M.A. Paldanius, GonÃ§alo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
published pages: 98-108, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.11.008
|Neurobiology of Aging 75||2020-03-11|
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The information about "PANA" are provided by the European Opendata Portal: CORDIS opendata.
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