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PHOTO ORGANO-GOLD SIGNED

Driving asymmetric photoreactions by merging organo- and gold-catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PHOTO ORGANO-GOLD project word cloud

Explore the words cloud of the PHOTO ORGANO-GOLD project. It provides you a very rough idea of what is the project "PHOTO ORGANO-GOLD" about.

unactivated    place    move    triggered    ideal    photo    frameworks    pharma    excellent    platform    avenues    community    alpha    drug    bromide    libraries    privileged    facilitated    era    pharmaceutical    combine    photoredox    amino    asymmetric    readily    chiral    host    bearing    gold    remarkable    world    position    acid    basic    chloride    dk    desirable    powerful    play    ing    small    enantiopure    broaden    alkyl    probability    unachievable    organic    disubstituted    fellow    perception    remained    cultural    activated    activation    compounds    assembling    career    date    molecules    catalysts    synthesis    structures    company    organocatalysis    natural    catalytic    molecule    easily    yields    comprising    copenhagen    oxindole    nature    discovery    prosperity    lundbeck    modern    otherwise    collection    seven    optimal       unrelated    reactions    chemistry    competencies    generating    mediated    screening    strategies    aryl    changing    candidate    light    visible    catalysis    ir    rh    chemical    photoreactions    biological   

Project "PHOTO ORGANO-GOLD" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-06   to  2018-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

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 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. Also, the chemistry community has recently recognized how visible light-mediated photoreactions can open new avenues in modern organic synthesis and the past seven years have witnessed its remarkable prosperity. Therefore, developing photo-facilitated asymmetric reactions focusing on rapidly generating privileged chiral natural-like compounds for drug discovery are highly desirable. The proposed research aims to combine the fellow’s experience in gold catalysis and the host’s experience in photo-triggered organocatalysis (two powerful fields of molecule activation, which have to date remained unrelated) to develop otherwise unachievable catalytic asymmetric photoreactions. Specifically, we will focus on using readily available, unactivated aryl/alkyl chloride or bromide, which cannot be easily activated by the commonly used Rh- or Ir-based photoredox catalysts. The resulting strategies will be used as an ideal platform for assembling libraries comprising enantiopure chiral small molecules bearing α,α-disubstituted α-amino acid & 3,3-disubstituted oxindole frameworks, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S, Copenhagen, DK), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

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