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PHOTO ORGANO-GOLD SIGNED

Driving asymmetric photoreactions by merging organo- and gold-catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PHOTO ORGANO-GOLD project word cloud

Explore the words cloud of the PHOTO ORGANO-GOLD project. It provides you a very rough idea of what is the project "PHOTO ORGANO-GOLD" about.

basic    enantiopure    desirable    lundbeck    triggered    perception    natural    rh    ir    place    easily    reactions    privileged    dk    molecules    catalysis    small    gold    chiral    photo    competencies    comprising    changing    avenues    position    host    acid    bromide    asymmetric    screening    remained    prosperity    career    pharma    mediated    remarkable    era    world    light    unachievable    photoredox    community    chemical    excellent    alpha    candidate    ing    activation    compounds    powerful    copenhagen    organocatalysis    move    catalytic    optimal    drug    organic    oxindole    molecule    catalysts    platform    collection    otherwise    ideal    pharmaceutical    facilitated    seven    generating    probability    frameworks       libraries    fellow    visible    broaden    amino    modern    combine    unrelated    date    disubstituted    structures    activated    chemistry    bearing    strategies    cultural    play    yields    unactivated    assembling    readily    company    photoreactions    alkyl    aryl    synthesis    discovery    chloride    biological    nature   

Project "PHOTO ORGANO-GOLD" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA 

Organization address
address: AVENIDA PAISSOS CATALANS 16
city: TARRAGONA
postcode: 43007
website: www.iciq.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.iciq.org/research/research_group/prof-paolo-melchiorre/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-06   to  2018-05-05

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA ES (TARRAGONA) coordinator 158˙121.00

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 Project objective

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. Also, the chemistry community has recently recognized how visible light-mediated photoreactions can open new avenues in modern organic synthesis and the past seven years have witnessed its remarkable prosperity. Therefore, developing photo-facilitated asymmetric reactions focusing on rapidly generating privileged chiral natural-like compounds for drug discovery are highly desirable. The proposed research aims to combine the fellow’s experience in gold catalysis and the host’s experience in photo-triggered organocatalysis (two powerful fields of molecule activation, which have to date remained unrelated) to develop otherwise unachievable catalytic asymmetric photoreactions. Specifically, we will focus on using readily available, unactivated aryl/alkyl chloride or bromide, which cannot be easily activated by the commonly used Rh- or Ir-based photoredox catalysts. The resulting strategies will be used as an ideal platform for assembling libraries comprising enantiopure chiral small molecules bearing α,α-disubstituted α-amino acid & 3,3-disubstituted oxindole frameworks, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S, Copenhagen, DK), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

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