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Functional analysis of Stress Granules formation in plant adaptation to stress

Total Cost €


EC-Contrib. €






 reSGulating project word cloud

Explore the words cloud of the reSGulating project. It provides you a very rough idea of what is the project "reSGulating" about.

responsive    causes    boosting    mrna    link    found    advantage    reinhardtii    efficient    energy    reducing    modulate    model    environmental    genetic    core    collaborations    useless    producing    endowed    despite    impaired    animal    prevent    regulate    fitness    arabidopsis    genes    compartmentalization    largely    compendium    contents    composition    clearance    evolutionary    worldwide    plants    mechanisms    cytoplasmic    disassembly    solid    threats    resistance    stresses    strengthen    expenditure    scientific    insights    mutants    cell    regulation    governs    assembly    crop    paving    kept    molecules    proteins    unknown    mrnas    50    optimal    photosynthetic    thaliana    plant    sgs    stored    stress    formative    fundamental    closer    molecular    structures    modulation    helping    mechanism    models    autophagy    yields    translation    chlamydomonas    species    biology    variety    career    alga    conserved    green    granules    limited    besides    anticipated    silent    recovery    primary    function    degraded    yeast   

Project "reSGulating" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Environmental stresses are the primary causes of crop loss worldwide, reducing average yields for most major crop plants by more than 50%. To get an optimal adaptation to environmental threats, plants have evolved a variety of complex and efficient mechanisms of resistance, including compartmentalization of mRNAs and proteins in cytoplasmic structures known as Stress Granules (SGs). In these, mRNA molecules are stored, degraded or kept silent in order to prevent energy expenditure on producing useless proteins, promoting thus the translation of specific stress-responsive genes that lead to the recovery from stress. Despite their importance in cell fitness, the overall composition of SGs, as well as their assembly requirements and regulation remain largely unknown. Although SGs have been found to be evolutionary conserved between species, the current knowledge of how plant SGs can regulate and modulate the response to stress is still limited. The overall objective of this proposal is to increase our understanding of the fundamental function of SGs on the regulation of plant response to stress. To this end, a compendium of methodologies including genetic and cell biology will be implemented in order to identify and characterize mutants impaired in SGs formation, taking advantage of well-established photosynthetic model systems such as Arabidopsis thaliana and the green alga Chlamydomonas reinhardtii. Given that autophagy is a core mechanism that governs the regulation of SGs formation, disassembly or clearance in animal and yeast models, this molecular link will be studied in higher plants. It is anticipated that implementation of this project will provide novel insights into SGs biology, helping to enhance our knowledge on the modulation of stress responses. Besides, the proposed project is endowed of solid formative contents that will strengthen my previous experience, boosting my future scientific career and paving the way for closer scientific collaborations.

 Work performed, outcomes and results:  advancements report(s) 

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