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reSGulating TERMINATED

Functional analysis of Stress Granules formation in plant adaptation to stress

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 reSGulating project word cloud

Explore the words cloud of the reSGulating project. It provides you a very rough idea of what is the project "reSGulating" about.

disassembly    function    compendium    fundamental    causes    optimal    composition    50    collaborations    evolutionary    mrnas    regulation    primary    scientific    advantage    solid    resistance    species    molecular    impaired    energy    governs    stress    variety    proteins    anticipated    formative    arabidopsis    modulate    insights    despite    link    reinhardtii    worldwide    besides    granules    limited    regulate    animal    cytoplasmic    cell    translation    autophagy    contents    found    mechanisms    genetic    reducing    helping    fitness    plant    photosynthetic    environmental    silent    stored    yields    unknown    molecules    sgs    clearance    crop    prevent    recovery    threats    paving    models    chlamydomonas    expenditure    career    genes    structures    strengthen    boosting    producing    responsive    compartmentalization    model    modulation    mrna    core    degraded    plants    green    stresses    thaliana    useless    mutants    biology    assembly    closer    efficient    mechanism    conserved    largely    kept    alga    endowed    yeast   

Project "reSGulating" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://twitter.com/stress_granules
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Environmental stresses are the primary causes of crop loss worldwide, reducing average yields for most major crop plants by more than 50%. To get an optimal adaptation to environmental threats, plants have evolved a variety of complex and efficient mechanisms of resistance, including compartmentalization of mRNAs and proteins in cytoplasmic structures known as Stress Granules (SGs). In these, mRNA molecules are stored, degraded or kept silent in order to prevent energy expenditure on producing useless proteins, promoting thus the translation of specific stress-responsive genes that lead to the recovery from stress. Despite their importance in cell fitness, the overall composition of SGs, as well as their assembly requirements and regulation remain largely unknown. Although SGs have been found to be evolutionary conserved between species, the current knowledge of how plant SGs can regulate and modulate the response to stress is still limited. The overall objective of this proposal is to increase our understanding of the fundamental function of SGs on the regulation of plant response to stress. To this end, a compendium of methodologies including genetic and cell biology will be implemented in order to identify and characterize mutants impaired in SGs formation, taking advantage of well-established photosynthetic model systems such as Arabidopsis thaliana and the green alga Chlamydomonas reinhardtii. Given that autophagy is a core mechanism that governs the regulation of SGs formation, disassembly or clearance in animal and yeast models, this molecular link will be studied in higher plants. It is anticipated that implementation of this project will provide novel insights into SGs biology, helping to enhance our knowledge on the modulation of stress responses. Besides, the proposed project is endowed of solid formative contents that will strengthen my previous experience, boosting my future scientific career and paving the way for closer scientific collaborations.

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