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Dynamic Origins of MHC class I Selector function

Total Cost €


EC-Contrib. €






 DynOMIS project word cloud

Explore the words cloud of the DynOMIS project. It provides you a very rough idea of what is the project "DynOMIS" about.

computational    fundamental    secretory    mechanisms    interactions    apparatus    peptides    energy    mhc    cofactors    antigenic    world    pave    comprising    biochemical    cancer    mechanism    sophisticated    thermodynamic    arsenal    dynomis    elucidate    drive    transformations    cell    immunological    mediator    integrates    employ    interdisciplinary    unleash    suitability    molecular    chemists    stratify    structural    simulations    class    exact    dynamics    quantitative    deep    cytotoxic    turn    immunity    molecules    adaptive    lymphocytes    calculations    industrial    clinically    epitopes    immune    antigen    basis    immunologists    cellular    group    vaccination    environment    immunoprotective    immunotherapy    function    surface    free    infections    context    peptide    experimental    timescales    healthy    pathogens    selecting    malignant    patients    investigation    equally    histocompatibility    vaccines    bound    predict    proteins    infectious    researcher    biomarkers    biologists    structure   

Project "DynOMIS" data sheet

The following table provides information about the project.


Organization address
address: Highfield
postcode: SO17 1BJ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-06   to  2018-09-05


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

DynOMIS aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level in the highly complex cellular environment. Major histocompatibility complex class I molecules (MHC-I) is a key mediator of adaptive immunity, the cell’s arsenal against infectious pathogens and malignant transformations. MHC-I present antigenic peptides to cytotoxic T lymphocytes at the cell surface, which in turn unleash their cytotoxic apparatus only when peptides from non-healthy proteins are recognized. This process is the result of an equally important peptide selecting function in the early secretory pathway, a mechanism that has not been clearly understood in spite of its fundamental role in vaccination. Deep understanding of the exact mechanisms that drive peptide selection by MHC-I will help to predict immunoprotective epitopes in infections and cancer, which will in turn pave the way for the development of more effective T cell-targeting vaccines and biomarkers to stratify patients’ suitability for immunotherapy. DynOMIS will employ a sophisticated, interdisciplinary approach that integrates quantitative computational systems modelling to identify molecular mechanism from cellular biochemical information, experimental investigation of the structure and dynamics of peptide-bound MHC-I over a large range of timescales, and state-of-the-art molecular dynamics simulations and free energy calculations to elucidate the thermodynamic basis of the peptide selection mechanism in the context of their interactions with cellular cofactors. To this end, DynOMIS will be carried out by an experienced researcher at a world-leading interdisciplinary group comprising molecular immunologists, structural biologists, computational chemists, and industrial partners with a strong focus on clinically relevant immunological research.


year authors and title journal last update
List of publications.
2017 Athanasios Papakyriakou, Efstratios Stratikos
The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00946
Frontiers in Immunology 8 2019-06-13
2018 Athanasios Papakyriakou, Emma Reeves, Mary Beton, Halina Mikolajek, Leon Douglas, Grace Cooper, Tim Elliott, Jörn M. Werner, Edward James
The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
published pages: 7538-7548, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.000313
Journal of Biological Chemistry 293/20 2019-05-09

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The information about "DYNOMIS" are provided by the European Opendata Portal: CORDIS opendata.

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