Opendata, web and dolomites

PURKINJEREG SIGNED

Identification of cellular identities and characterization of the STAT3 signalling pathway in Purkinje cell layer regeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PURKINJEREG project word cloud

Explore the words cloud of the PURKINJEREG project. It provides you a very rough idea of what is the project "PURKINJEREG" about.

tissue    injuries    transgenic    degeneration    considering    signaling    ablated    model    therapeutic    reveal    locomotor    functions    employing    de    potentials    inhibitor    cerebellar    organism    neuronal    severe    time    fundamental    stat3    regeneration    capacity    zebrafish    rely    inducible    cerebellum    sources    pc    regenerating    extremely    revealing    neurons    sole    revealed    output    there    tests    diseases    accompanying    mammals    derive    cell    spatial    molecular    neurogenesis    involve    elucidate    mechanical    unknown    behavioral    first    roles    differentiating    constraints    adult    vertebrate    brain    ataxia    layer    suffer    symptoms    candidate    protocols    insights    degenerative    regenerative    migratory    strains    double    superior    cells    technique    plasticity    pcs    remaining    interactions    progenitors    proper    routes    course    ablation    mechanisms    obtain    novo    tool    exhibits    basic    purkinje    restoration    certain    recovery    extensive    treating    functional    cellular   

Project "PURKINJEREG" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAET BRAUNSCHWEIG 

Organization address
address: UNIVERSITAETSPLATZ 2
city: BRAUNSCHWEIG
postcode: 38106
website: www.tu-braunschweig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.tu-braunschweig.de/zoology/forschung/cellularmolecularneurobiology/focus/regeneration
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAET BRAUNSCHWEIG DE (BRAUNSCHWEIG) coordinator 159˙460.00

Map

 Project objective

There are many degenerative diseases affecting the cerebellum (as certain cerebellar ataxia) with severe locomotor symptoms, in which the Purkinje cells (PCs), the sole-output cerebellar neurons, suffer from degeneration. The adult regenerative capacity of neurons in mammals is extremely low. However, the zebrafish is a model organism that exhibits extensive adult neurogenesis and regeneration, and is therefore most likely to elucidate key cerebellar regenerative mechanisms that are currently unknown. The proposed project will focus on the study of PC regeneration using an inducible cell type specific ablation technique, in which the recovery of PCs cannot involve the plasticity of remaining cells, making this tool superior to existing protocols which rely on mechanical injuries. In such PC-ablated zebrafish the time course of PC layer recovery will be analyzed by behavioral tests, which will also reveal specific functions of the zebrafish cerebellum. Cellular processes of regeneration will be revealed by the analysis of double transgenic zebrafish strains addressing: the cellular sources of regenerating PC progenitors, their spatial distribution, potential migratory routes of de novo differentiating PCs, and cellular interactions accompanying a proper restoration of a functional PC layer. We also expect to obtain first insights into potential molecular processes involved in the degeneration-regeneration processes of PCs, considering Stat3- signaling (with important roles in tissue restoration) as a promising candidate to promote PC regeneration by employing inhibitor studies, and to derive functional consequences for the organism. These results are fundamental to understanding and eventually treating diseases affecting the cerebellum. Therefore, these studies about PCs regeneration in zebrafish will reach beyond basic research by revealing molecular and cellular potentials and constraints for neuronal regeneration therapeutic approaches in the vertebrate brain.

 Publications

year authors and title journal last update
List of publications.
2018 G. Russo, F. Lehne, S. M. Pose Méndez, S. Dübel, R. W. Köster, W. A. Sassen
Culture and transfection of zebrafish primary cells
published pages: , ISSN: 1940-087X, DOI:
Journal of Visualized Experiments monthly 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PURKINJEREG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PURKINJEREG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TeamUp (2020)

Understanding and improving team decision making in uncertain environments

Read More  

IRF4 Degradation (2019)

Using a novel protein degradation approach to uncover IRF4-regulated genes in plasma cells

Read More