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HippBoundariesPE

Identifying the building blocks of episodic memory: how the hippocampus parses boundless experience into discrete events

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HippBoundariesPE project word cloud

Explore the words cloud of the HippBoundariesPE project. It provides you a very rough idea of what is the project "HippBoundariesPE" about.

hypothesize    elucidate    first    interpreted    segments    illuminate    amnesic    dissociate    ameliorating    designed    forms    involvement    stream    complementary    individuals    segmentation    brief    hippocampal    boundary    patients    events    encoding    significance    host    ongoing    discrete    focal    registered    occurrences    expertise    ends    memory    collaborations    7t    region    episodic    event    fails    lesions    interventions    nature    provides    researcher    pe    employed    subfields    surprising    disorders    distinction    clips    boundaries    mnemonic    received    healthy    hippocampus    film    normal    prediction    continuous    salient    units    laid    induce    error    applicable    posit    expectancy    perceptual    previously    fmri    few    infancy    life    theories    linked    lays    recognition    employing    surprise    neuropsychological    combining    occur    differ    stimuli    significantly    segment    constitutes    upcoming    explicit   

Project "HippBoundariesPE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.mrc-cbu.cam.ac.uk/people/aya.ben-yakov/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-08-18   to  2018-08-17

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 103˙563.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 79˙891.00

Map

 Project objective

Life provides us with a continuous stream of information that ends up being organized in long-term memory as distinct events. How does this occur? Leading theories posit that surprising occurrences (when prediction of the immediate future fails) are interpreted by the system as event boundaries that segment ongoing experience. Will any type of surprise induce such segmentation? Moreover, how are these segments then laid down in memory as discrete units? The proposed research addresses these key issues in a two phase study, combining fMRI of healthy individuals with a neuropsychological study of amnesic patients, and using tailored film clips designed to dissociate between distinct forms of prediction error (PE) – low-level PE (salient perceptual changes) and high-level PE (explicit expectancy of an upcoming change). We hypothesize that the key region in this process may be the hippocampus, a region strongly linked to formation of episodic memory. Combining a 7T fMRI study (enabling distinction between hippocampal subfields) with a study of patients with focal hippocampal lesions will enable us to elucidate the nature and necessity of hippocampal involvement in segmentation. The significance of this study lays first in its potential to illuminate how real-life events are registered to memory, a process which is likely to differ significantly from the encoding of brief, simple stimuli that have been employed previously. The importance of studying encoding of complex events has recently received increasing recognition, yet this is still only at its infancy, with very few studies employing this approach. Combining the complementary expertise of the researcher and the host, the proposed research aims to identify what constitutes an event boundary in mnemonic processing. Through future collaborations, this has the potential to lead to applicable interventions for improving normal memory and ameliorating mnemonic disorders.

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