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HippBoundariesPE

Identifying the building blocks of episodic memory: how the hippocampus parses boundless experience into discrete events

Total Cost €

0

EC-Contrib. €

0

Partnership

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 HippBoundariesPE project word cloud

Explore the words cloud of the HippBoundariesPE project. It provides you a very rough idea of what is the project "HippBoundariesPE" about.

infancy    previously    hippocampus    involvement    interpreted    memory    segmentation    lays    constitutes    encoding    first    fmri    hypothesize    elucidate    region    theories    neuropsychological    few    combining    prediction    applicable    error    fails    complementary    linked    surprise    received    occurrences    mnemonic    events    researcher    pe    focal    lesions    surprising    distinction    normal    7t    subfields    induce    continuous    differ    host    discrete    laid    forms    ends    employing    patients    segment    film    significantly    collaborations    significance    explicit    individuals    interventions    posit    recognition    boundary    ongoing    event    clips    nature    dissociate    provides    hippocampal    healthy    stimuli    perceptual    units    illuminate    stream    brief    episodic    boundaries    expectancy    employed    salient    segments    upcoming    disorders    designed    registered    life    amnesic    ameliorating    occur    expertise   

Project "HippBoundariesPE" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.mrc-cbu.cam.ac.uk/people/aya.ben-yakov/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-08-18   to  2018-08-17

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 103˙563.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 79˙891.00

Map

 Project objective

Life provides us with a continuous stream of information that ends up being organized in long-term memory as distinct events. How does this occur? Leading theories posit that surprising occurrences (when prediction of the immediate future fails) are interpreted by the system as event boundaries that segment ongoing experience. Will any type of surprise induce such segmentation? Moreover, how are these segments then laid down in memory as discrete units? The proposed research addresses these key issues in a two phase study, combining fMRI of healthy individuals with a neuropsychological study of amnesic patients, and using tailored film clips designed to dissociate between distinct forms of prediction error (PE) – low-level PE (salient perceptual changes) and high-level PE (explicit expectancy of an upcoming change). We hypothesize that the key region in this process may be the hippocampus, a region strongly linked to formation of episodic memory. Combining a 7T fMRI study (enabling distinction between hippocampal subfields) with a study of patients with focal hippocampal lesions will enable us to elucidate the nature and necessity of hippocampal involvement in segmentation. The significance of this study lays first in its potential to illuminate how real-life events are registered to memory, a process which is likely to differ significantly from the encoding of brief, simple stimuli that have been employed previously. The importance of studying encoding of complex events has recently received increasing recognition, yet this is still only at its infancy, with very few studies employing this approach. Combining the complementary expertise of the researcher and the host, the proposed research aims to identify what constitutes an event boundary in mnemonic processing. Through future collaborations, this has the potential to lead to applicable interventions for improving normal memory and ameliorating mnemonic disorders.

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