Opendata, web and dolomites

JHSIGNAL

Modulation of juvenile hormone signaling by receptor phosphorylation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 JHSIGNAL project word cloud

Explore the words cloud of the JHSIGNAL project. It provides you a very rough idea of what is the project "JHSIGNAL" about.

host    sites    lipophilic    vectors    achievable    extensively    dr    determined    animals    chemistry    capacity    drosophila    goals    significance    relying    pests    mutated    beneficial    molecular    biochemistry    insects    marek    successful    combined    jhs    fundamental    trained    biology    expertise    jh    receptor    lines    potentially    modulated    signaling    protein    laboratory    genes    permanently    regulation    spectrometry    agricultural    constitutively    integrating    hormones    practical    either    normal    species    insecticide    phosphorylation    function    vital    examined    disease    mimic    insect    assays    signals    prevent    status    phosphorylated    poorly    employing    ranking    planet    universities    pollinators    endocrinology    expand    model    science    developmental    genetics    bind    receptors    manipulation    juvenile    acid    good    representing    expressed    sustain    cell    induce    arthropods    mass    amino    residues    suggests    largely    mutant    vivo    ranges    leaders    action    crustaceans    jindra    group    intracellular   

Project "JHSIGNAL" data sheet

The following table provides information about the project.

Coordinator
Biologicke centrum AV CR, v. v. i. 

Organization address
address: Branisovska 31
city: CESKE BUDEJOVICE
postcode: 370 05
website: www.bc.cas.cz

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Project website https://marek-jindra-lab.webnode.cz/jhsignal-project/
 Total cost 154˙720 €
 EC max contribution 154˙720 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Biologicke centrum AV CR, v. v. i. CZ (CESKE BUDEJOVICE) coordinator 154˙720.00

Map

 Project objective

Juvenile hormones (JHs) are lipophilic signals of vital importance to insects and related arthropods, representing the most successful group of animals on our planet. Among species relying on regulation by JH are beneficial pollinators and crustaceans, as well as agricultural pests and disease vectors. Manipulation of JH signaling is a good target for insecticide control. Therefore, knowledge of JH signaling is important both for fundamental science and for practical use. The intracellular JH receptor has been identified, largely through work in the host laboratory, but its action is still poorly understood. Current evidence suggests that activity of this JH receptor is modulated by JH-induced phosphorylation. The objective of this proposal is to identify the phosphorylation target sites and to determine their significance for the JH receptor function. To achieve this goal, the status of amino acid residues potentially phosphorylated in response to JH will be determined using mass spectrometry of the JH receptor protein expressed in insect cell lines. The key residues will be mutated either to prevent phosphorylation or to mimic a constitutively phosphorylated state, and the mutant receptors will be examined for capacity to bind JH, induce JH-response genes, and sustain normal insect development in vivo. The approach thus ranges from protein biochemistry through cell-based assays to developmental genetics employing the Drosophila model. The goals are achievable through the combined expertise of the Applicant, extensively trained in protein chemistry and molecular biology at the top-ranking US universities, and the host laboratory of Dr. Marek Jindra, who is among the leaders in insect developmental endocrinology and JH research in particular. This project will enable the Applicant to fully expand her potential and learn insect developmental genetics while permanently integrating to European science.

 Publications

year authors and title journal last update
List of publications.
2019 Lenka Bittova, Pavel Jedlicka, Martin Dracinsky, Palani Kirubakaran, Jiri Vondrasek, Robert Hanus, Marek Jindra
Exquisite ligand stereoselectivity of a Drosophila juvenile hormone receptor contrasts with its broad agonist repertoire
published pages: 410-423, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.005992
Journal of Biological Chemistry 294/2 2019-06-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "JHSIGNAL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "JHSIGNAL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TIPTOP (2019)

Tensoring Positive Maps on Operator Structures

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More