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Modulation of juvenile hormone signaling by receptor phosphorylation

Total Cost €


EC-Contrib. €






 JHSIGNAL project word cloud

Explore the words cloud of the JHSIGNAL project. It provides you a very rough idea of what is the project "JHSIGNAL" about.

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Project "JHSIGNAL" data sheet

The following table provides information about the project.

Biologicke centrum AV CR, v. v. i. 

Organization address
address: Branisovska 31
postcode: 370 05

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Project website
 Total cost 154˙720 €
 EC max contribution 154˙720 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Biologicke centrum AV CR, v. v. i. CZ (CESKE BUDEJOVICE) coordinator 154˙720.00


 Project objective

Juvenile hormones (JHs) are lipophilic signals of vital importance to insects and related arthropods, representing the most successful group of animals on our planet. Among species relying on regulation by JH are beneficial pollinators and crustaceans, as well as agricultural pests and disease vectors. Manipulation of JH signaling is a good target for insecticide control. Therefore, knowledge of JH signaling is important both for fundamental science and for practical use. The intracellular JH receptor has been identified, largely through work in the host laboratory, but its action is still poorly understood. Current evidence suggests that activity of this JH receptor is modulated by JH-induced phosphorylation. The objective of this proposal is to identify the phosphorylation target sites and to determine their significance for the JH receptor function. To achieve this goal, the status of amino acid residues potentially phosphorylated in response to JH will be determined using mass spectrometry of the JH receptor protein expressed in insect cell lines. The key residues will be mutated either to prevent phosphorylation or to mimic a constitutively phosphorylated state, and the mutant receptors will be examined for capacity to bind JH, induce JH-response genes, and sustain normal insect development in vivo. The approach thus ranges from protein biochemistry through cell-based assays to developmental genetics employing the Drosophila model. The goals are achievable through the combined expertise of the Applicant, extensively trained in protein chemistry and molecular biology at the top-ranking US universities, and the host laboratory of Dr. Marek Jindra, who is among the leaders in insect developmental endocrinology and JH research in particular. This project will enable the Applicant to fully expand her potential and learn insect developmental genetics while permanently integrating to European science.


year authors and title journal last update
List of publications.
2019 Lenka Bittova, Pavel Jedlicka, Martin Dracinsky, Palani Kirubakaran, Jiri Vondrasek, Robert Hanus, Marek Jindra
Exquisite ligand stereoselectivity of a Drosophila juvenile hormone receptor contrasts with its broad agonist repertoire
published pages: 410-423, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.005992
Journal of Biological Chemistry 294/2 2019-06-05

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