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TACT SIGNED

Towards an objective and quantitative Assessment of human Corneal Transparency

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TACT project word cloud

Explore the words cloud of the TACT project. It provides you a very rough idea of what is the project "TACT" about.

subtle    media    host    vision    resolve    capability    segment    full    la    coherence    clinical    prevention    anterior    ocular    qualitatively    langevin    fellowship    spur    lacks    ease    opacity    scattering    focal    ageing    aside    inherent    critical    compromised    illumination    carry    trauma    monitored    subjective    patient    practical    usually    worldwide    auspices    tomography    pathologies    lamp    basic    characterization    acuity    objectively    ideal    ophthalmology    quantitative    independent    monitor    transparencies    reproducibility    quantify    investigations    register    improvements    subjectively    wavelength    continue    poor    slit    direct    cornea    surgery    position    drawbacks    optical    million    alone    causes    qualitative    treatment    institut    infections    imaging    biomicroscopy    investigates    excellent    dependent    researcher    deep    visual    polarized    tool    diagnosis    light    interface    hence    avenues    candidate    penetration    corneal    blindness    validating    resolution    innovations    biomicroscope    care    matrix    transparency    de    unmet    physics    modalities    lack    ffoct    people   

Project "TACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.institut-vision.org/fr/recherche/projets.html
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 173˙076.00
2    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 FR (PARIS) coordinator 0.00

Map

 Project objective

Visual acuity is dependent upon the transparency of the cornea. Corneal transparency can be compromised by various pathologies, infections, trauma, ageing, and surgery, all of which result in increased light scattering. Lack of ocular anterior segment transparency is the leading cause of blindness worldwide, with corneal causes alone affecting over 10 million people. In current clinical ophthalmology practice, corneal transparency is usually monitored subjectively and qualitatively via direct focal illumination using a slit-lamp biomicroscope. Aside from inherent subjective and qualitative drawbacks, including poor reproducibility, this method lacks the capability to register and resolve changes in opacity that may be subtle. Hence, there is a critical need for a reliable and practical tool to objectively quantify, characterize, and monitor corneal transparency towards effective prevention, diagnosis, and treatment. The overall objective of this research programme is to address this unmet need by developing and validating advanced concepts and novel imaging modalities tailored to the needs of cornea assessment. The programme investigates (1) Quantitative Polarized Slit-lamp Biomicroscopy, (2) Multi-Wavelength Full-Field Optical Coherence Tomography (FFOCT), and (3) Multi-Illumination Matrix FFOCT; all enabling ease of use, high resolution, and deep light-penetration characterization and imaging. The candidate will be in an excellent position to carry out the programme under the auspices of the ideal host (Institut de la Vision) and the ideal partner (Institut Langevin). The research will enhance our basic understanding of corneal transparency as well as lead to major changes and improvements in patient care and management. It will, moreover, open new avenues and spur further investigations of ocular media transparencies. The Fellowship will enable the candidate to continue innovations at the interface of physics and ophthalmology as an independent researcher.

 Publications

year authors and title journal last update
List of publications.
2018 Viacheslav Mazlin, Peng Xiao, Eugénie Dalimier, Kate Grieve, Kristina Irsch, José-Alain Sahel, Mathias Fink, A. Claude Boccara
In vivo high resolution human corneal imaging using full-field optical coherence tomography
published pages: 557, ISSN: 2156-7085, DOI: 10.1364/BOE.9.000557
Biomedical Optics Express 9/2 2019-05-23
2019 Kristina Irsch, Kate Grieve, Marie Borderie, Djida Ghoubay, Cristina Georgeon, Vincent Borderie
Full-field Optical Coherence Microscopy for Histology-like Analysis of Stromal Features in Corneal Grafts
published pages: , ISSN: 1940-087X, DOI:
JoVE 2019-05-23

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The information about "TACT" are provided by the European Opendata Portal: CORDIS opendata.

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