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TACT SIGNED

Towards an objective and quantitative Assessment of human Corneal Transparency

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TACT project word cloud

Explore the words cloud of the TACT project. It provides you a very rough idea of what is the project "TACT" about.

subtle    physics    pathologies    biomicroscopy    deep    clinical    capability    polarized    drawbacks    compromised    imaging    care    wavelength    register    position    spur    ageing    aside    researcher    acuity    dependent    resolve    matrix    visual    reproducibility    illumination    monitored    diagnosis    tool    scattering    institut    objectively    excellent    slit    trauma    tomography    full    biomicroscope    ideal    media    quantify    causes    host    subjective    ffoct    inherent    ocular    usually    improvements    hence    lack    million    continue    validating    investigations    segment    candidate    transparencies    monitor    unmet    alone    surgery    vision    resolution    investigates    modalities    ease    langevin    critical    direct    penetration    fellowship    quantitative    de    worldwide    prevention    interface    light    lacks    poor    avenues    auspices    patient    la    cornea    optical    practical    subjectively    qualitatively    ophthalmology    coherence    basic    lamp    infections    focal    characterization    qualitative    people    corneal    independent    innovations    anterior    carry    transparency    opacity    treatment    blindness   

Project "TACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.institut-vision.org/fr/recherche/projets.html
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 173˙076.00
2    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 FR (PARIS) coordinator 0.00

Map

 Project objective

Visual acuity is dependent upon the transparency of the cornea. Corneal transparency can be compromised by various pathologies, infections, trauma, ageing, and surgery, all of which result in increased light scattering. Lack of ocular anterior segment transparency is the leading cause of blindness worldwide, with corneal causes alone affecting over 10 million people. In current clinical ophthalmology practice, corneal transparency is usually monitored subjectively and qualitatively via direct focal illumination using a slit-lamp biomicroscope. Aside from inherent subjective and qualitative drawbacks, including poor reproducibility, this method lacks the capability to register and resolve changes in opacity that may be subtle. Hence, there is a critical need for a reliable and practical tool to objectively quantify, characterize, and monitor corneal transparency towards effective prevention, diagnosis, and treatment. The overall objective of this research programme is to address this unmet need by developing and validating advanced concepts and novel imaging modalities tailored to the needs of cornea assessment. The programme investigates (1) Quantitative Polarized Slit-lamp Biomicroscopy, (2) Multi-Wavelength Full-Field Optical Coherence Tomography (FFOCT), and (3) Multi-Illumination Matrix FFOCT; all enabling ease of use, high resolution, and deep light-penetration characterization and imaging. The candidate will be in an excellent position to carry out the programme under the auspices of the ideal host (Institut de la Vision) and the ideal partner (Institut Langevin). The research will enhance our basic understanding of corneal transparency as well as lead to major changes and improvements in patient care and management. It will, moreover, open new avenues and spur further investigations of ocular media transparencies. The Fellowship will enable the candidate to continue innovations at the interface of physics and ophthalmology as an independent researcher.

 Publications

year authors and title journal last update
List of publications.
2018 Viacheslav Mazlin, Peng Xiao, Eugénie Dalimier, Kate Grieve, Kristina Irsch, José-Alain Sahel, Mathias Fink, A. Claude Boccara
In vivo high resolution human corneal imaging using full-field optical coherence tomography
published pages: 557, ISSN: 2156-7085, DOI: 10.1364/BOE.9.000557
Biomedical Optics Express 9/2 2019-05-23
2019 Kristina Irsch, Kate Grieve, Marie Borderie, Djida Ghoubay, Cristina Georgeon, Vincent Borderie
Full-field Optical Coherence Microscopy for Histology-like Analysis of Stromal Features in Corneal Grafts
published pages: , ISSN: 1940-087X, DOI:
JoVE 2019-05-23

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The information about "TACT" are provided by the European Opendata Portal: CORDIS opendata.

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