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REFOLDAMER

Communication through Polarity-Switchable Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 REFOLDAMER project word cloud

Explore the words cloud of the REFOLDAMER project. It provides you a very rough idea of what is the project "REFOLDAMER" about.

outstanding    hydrogen    dynamic    networks    coupled    ligand    synthetic    single    innovate    helical    global    foldamers    communicate    read    nucleotide    bond    patterns    untapped    career    combined    sequences    carry    nanoscale    bio    translation    encoded    class    conceptually    edge    artificial    scientist    telescope    length    dna    transcription    transfer    full    biological    preference    remote    directionality    receptor    horizons    cutting    reversal    arrangements    dimensional    switching    communicated    spectroscopic    foldamer    source    screw    stored    binding    clayden    site    mechanism    communication    local    acceptors    molecule    storage    reversible    protein    mimic    sense    exploited    bonding    refoldable    hence    area    reminiscent    receptors    donors    chemical    catalytic    reorganisation    structure    rna    translate    communicating    event    chemistry    shape    conformational    boundary    inspired    mechanisms    manner    science    biology    competitiveness    polarity   

Project "REFOLDAMER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.claydenchemistry.net
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-04   to  2018-04-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

We propose to develop a new, artificial but bio-inspired mechanism for communicating information in chemical systems, by using the potential for hydrogen-bond reorganisation of novel dynamic 'refoldable foldamers', combined with biology's information storage mechanisms. Biological information is encoded in DNA or RNA by two dimensional arrangements of hydrogen bond donors and acceptors in nucleotide sequences: we will innovate nanoscale communication devices that read information encoded in this way, and translate it directly into a chemical feature (catalytic activity, ligand-binding ability) at a site remote from the source of information. Conceptually we shall telescope the biological processes of transcription and translation into a single conformational event in a single molecule. We will develop a new class of polarity-reversible foldamers as artificial receptors to translate information stored in hydrogen bonding patterns into a local conformational preference. The preference will be communicated the full length of the foldamer by means of a global change in shape, and used to define the detailed structure and hence spectroscopic and chemical properties at another site in the molecule. Those devices will mimic biology’s ability to communicate information in a manner reminiscent of the G-protein coupled receptor. Dynamic foldamer conformational switching will be based on reversible hydrogen-bond polarity rather than on helical screw sense switching recently used by Clayden to carry information: reversal in directionality of hydrogen bond networks has not yet been exploited. Success would open up a new area of science at the boundary of synthetic chemistry and biology, facilitating new developments in as-yet untapped applications of dynamic foldamers, improving European Science competitiveness. Transfer of cutting edge knowledge to a European scientist of outstanding potential will greatly enhance his career horizons.

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The information about "REFOLDAMER" are provided by the European Opendata Portal: CORDIS opendata.

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