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REFOLDAMER

Communication through Polarity-Switchable Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 REFOLDAMER project word cloud

Explore the words cloud of the REFOLDAMER project. It provides you a very rough idea of what is the project "REFOLDAMER" about.

chemical    edge    mechanism    bond    communicate    spectroscopic    single    polarity    helical    exploited    nanoscale    scientist    ligand    networks    artificial    dna    foldamer    directionality    mechanisms    innovate    nucleotide    rna    conformational    reversal    outstanding    stored    receptor    global    telescope    communicating    area    biology    full    science    bio    sense    inspired    storage    hence    biological    acceptors    coupled    screw    mimic    molecule    shape    communication    untapped    length    reminiscent    communicated    switching    source    bonding    competitiveness    patterns    local    refoldable    class    horizons    conceptually    protein    boundary    receptors    catalytic    site    sequences    translate    chemistry    encoded    career    dynamic    donors    read    cutting    reversible    transcription    dimensional    carry    arrangements    reorganisation    event    preference    clayden    combined    structure    synthetic    foldamers    binding    hydrogen    transfer    manner    translation    remote   

Project "REFOLDAMER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.claydenchemistry.net
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-04   to  2018-04-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

We propose to develop a new, artificial but bio-inspired mechanism for communicating information in chemical systems, by using the potential for hydrogen-bond reorganisation of novel dynamic 'refoldable foldamers', combined with biology's information storage mechanisms. Biological information is encoded in DNA or RNA by two dimensional arrangements of hydrogen bond donors and acceptors in nucleotide sequences: we will innovate nanoscale communication devices that read information encoded in this way, and translate it directly into a chemical feature (catalytic activity, ligand-binding ability) at a site remote from the source of information. Conceptually we shall telescope the biological processes of transcription and translation into a single conformational event in a single molecule. We will develop a new class of polarity-reversible foldamers as artificial receptors to translate information stored in hydrogen bonding patterns into a local conformational preference. The preference will be communicated the full length of the foldamer by means of a global change in shape, and used to define the detailed structure and hence spectroscopic and chemical properties at another site in the molecule. Those devices will mimic biology’s ability to communicate information in a manner reminiscent of the G-protein coupled receptor. Dynamic foldamer conformational switching will be based on reversible hydrogen-bond polarity rather than on helical screw sense switching recently used by Clayden to carry information: reversal in directionality of hydrogen bond networks has not yet been exploited. Success would open up a new area of science at the boundary of synthetic chemistry and biology, facilitating new developments in as-yet untapped applications of dynamic foldamers, improving European Science competitiveness. Transfer of cutting edge knowledge to a European scientist of outstanding potential will greatly enhance his career horizons.

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The information about "REFOLDAMER" are provided by the European Opendata Portal: CORDIS opendata.

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