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REFOLDAMER

Communication through Polarity-Switchable Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 REFOLDAMER project word cloud

Explore the words cloud of the REFOLDAMER project. It provides you a very rough idea of what is the project "REFOLDAMER" about.

chemistry    chemical    local    science    telescope    inspired    artificial    single    foldamer    innovate    cutting    acceptors    coupled    communication    conceptually    nanoscale    clayden    helical    networks    untapped    biological    protein    bio    refoldable    donors    binding    storage    ligand    reversal    hence    global    reversible    hydrogen    sense    exploited    arrangements    source    reminiscent    bond    boundary    career    mimic    stored    outstanding    length    transcription    encoded    synthetic    screw    reorganisation    receptors    dimensional    event    foldamers    competitiveness    communicated    patterns    full    mechanisms    combined    sequences    carry    molecule    conformational    preference    scientist    read    class    catalytic    transfer    biology    switching    receptor    site    mechanism    manner    nucleotide    structure    edge    area    dna    communicating    spectroscopic    rna    horizons    remote    translation    dynamic    translate    polarity    communicate    shape    bonding    directionality   

Project "REFOLDAMER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.claydenchemistry.net
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-04   to  2018-04-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

We propose to develop a new, artificial but bio-inspired mechanism for communicating information in chemical systems, by using the potential for hydrogen-bond reorganisation of novel dynamic 'refoldable foldamers', combined with biology's information storage mechanisms. Biological information is encoded in DNA or RNA by two dimensional arrangements of hydrogen bond donors and acceptors in nucleotide sequences: we will innovate nanoscale communication devices that read information encoded in this way, and translate it directly into a chemical feature (catalytic activity, ligand-binding ability) at a site remote from the source of information. Conceptually we shall telescope the biological processes of transcription and translation into a single conformational event in a single molecule. We will develop a new class of polarity-reversible foldamers as artificial receptors to translate information stored in hydrogen bonding patterns into a local conformational preference. The preference will be communicated the full length of the foldamer by means of a global change in shape, and used to define the detailed structure and hence spectroscopic and chemical properties at another site in the molecule. Those devices will mimic biology’s ability to communicate information in a manner reminiscent of the G-protein coupled receptor. Dynamic foldamer conformational switching will be based on reversible hydrogen-bond polarity rather than on helical screw sense switching recently used by Clayden to carry information: reversal in directionality of hydrogen bond networks has not yet been exploited. Success would open up a new area of science at the boundary of synthetic chemistry and biology, facilitating new developments in as-yet untapped applications of dynamic foldamers, improving European Science competitiveness. Transfer of cutting edge knowledge to a European scientist of outstanding potential will greatly enhance his career horizons.

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The information about "REFOLDAMER" are provided by the European Opendata Portal: CORDIS opendata.

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