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EvoStruc SIGNED

The physics of antibiotic resistance evolution in spatially-structured multicellular assemblies

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EvoStruc" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www2.ph.ed.ac.uk/
 Total cost 1˙826˙984 €
 EC max contribution 1˙826˙984 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙826˙984.00

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 Project objective

The rise in bacterial infections that are resistant to antibiotic treatment poses a major global health challenge. Addressing this challenge is not just a clinical issue: understanding bacterial resistance evolution calls for an interdisciplinary approach, in which the development of new physics, in coordination with biology, chemistry and engineering, has a central role to play. In particular, statistical physics, to predict the stochastic emergence of drug-resistant mutants, must be integrated with soft matter and chemical physics, to understand the spatial organization of the bacterial populations within which this happens.

Bacterial infections are very often spatially heterogeneous. This is known to influence the outcome of antibiotic treatment – for example bacterial biofilms, which form on the surfaces of medical implants, are notoriously hard to remove. However, much less attention has been paid to the role of spatial structure in the evolution of drug resistance, i.e. the emergence and spread of genetically drug-resistant bacterial strains.

I will lead a research programme which will for the first time uncover the two-way link between the emergence of spatial structure in bacterial multicellular assemblies and the evolution of drug resistance. The programme builds on my current theoretical, simulation and experimental work. I will first determine the basic principles of evolution in drug gradients using theoretical models, combined with experiments in a controlled, 1D geometry. I will then explore how these principles translate to the more realistic scenario of bacterial biofilms, where spatial structure and drug gradients are emergent properties, using advanced computer simulation methods and both confocal microscopy and evolution experiments. In the final part of the programme, I will use these insights to reveal optimization principles for the design of evolution-resistant surface coatings for applications in medical devices.

 Publications

year authors and title journal last update
List of publications.
2019 Patrick Sinclair, Martín Carballo-Pacheco, Rosalind J Allen
Growth-dependent drug susceptibility can prevent or enhance spatial expansion of a bacterial population
published pages: 46001, ISSN: 1478-3975, DOI: 10.1088/1478-3975/ab131e
Physical Biology 16/4 2020-01-29
2017 Philip Greulich, Jakub Doležal, Matthew Scott, Martin R Evans, Rosalind J Allen
Predicting the dynamics of bacterial growth inhibition by ribosome-targeting antibiotics
published pages: 65005, ISSN: 1478-3975, DOI: 10.1088/1478-3975/aa8001
Physical Biology 14/6 2020-01-29
2016 Rosalind Allen, Bartłomiej Waclaw
Antibiotic resistance: a physicist’s view
published pages: 45001, ISSN: 1478-3975, DOI: 10.1088/1478-3975/13/4/045001
Physical Biology 13/4 2020-01-29
2018 Craig Watson, Paul Hush, Joshua Williams, Angela Dawson, Nikola Ojkic, Simon Titmuss, Bartlomiej Waclaw
Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies (a)
published pages: 68001, ISSN: 1286-4854, DOI: 10.1209/0295-5075/123/68001
EPL (Europhysics Letters) 123/6 2020-01-29
2019 Rosalind J Allen, Bartlomiej Waclaw
Bacterial growth: a statistical physicist’s guide
published pages: 16601, ISSN: 0034-4885, DOI: 10.1088/1361-6633/aae546
Reports on Progress in Physics 82/1 2020-01-29

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