RISK - IR

"Risk, Stem Cells and Tissue Kinetics – Ionising Radiation"

 Coordinatore Department of Health 

 Organization address address: Quarry House, Quarry Hill
city: Leeds
postcode: LS2 7UE

contact info
Titolo: Mr.
Nome: Paul
Cognome: Barty
Email: send email
Telefono: +44 1235 825445
Fax: +44 1235 833891

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 8˙597˙164 €
 EC contributo 6˙685˙000 €
 Programma FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection
 Code Call FP7-Fission-2012
 Funding Scheme CP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2017-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    Department of Health

 Organization address address: Quarry House, Quarry Hill
city: Leeds
postcode: LS2 7UE

contact info
Titolo: Mr.
Nome: Paul
Cognome: Barty
Email: send email
Telefono: +44 1235 825445
Fax: +44 1235 833891

UK (Leeds) coordinator 1˙292˙548.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Dr.
Nome: Michele
Cognome: Martin
Email: send email
Telefono: +33 1 60873491
Fax: +33 1 60873498

FR (PARIS 15) participant 2˙029˙427.00
3    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Liesbeth
Cognome: Dorama
Email: send email
Telefono: +31 71 526 9569
Fax: +31 71 526 8275

NL (LEIDEN) participant 622˙520.00
4    UNIVERSITY OF SUSSEX

 Organization address address: Sussex House
city: FALMER, BRIGHTON
postcode: BN1 9RH

contact info
Titolo: Ms.
Nome: Bettina
Cognome: Lehmbeck
Email: send email
Telefono: +44 1273 877960
Fax: +44 1273 678192

UK (FALMER, BRIGHTON) participant 481˙035.00
5    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

 Organization address address: The Old Schools, Trinity Lane
city: CAMBRIDGE
postcode: CB2 1TN

contact info
Titolo: Mrs.
Nome: Dimple
Cognome: Fernado
Email: send email
Telefono: 441223000000
Fax: +441223 332988

UK (CAMBRIDGE) participant 410˙000.00
6    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Dr.
Nome: Dolores
Cognome: Liebanes
Email: send email
Telefono: +34 912246900

ES (MADRID) participant 399˙244.00
7    TECHNISCHE UNIVERSITAET DARMSTADT

 Organization address address: Karolinenplatz 5
city: DARMSTADT
postcode: 64289

contact info
Titolo: Prof.
Nome: Markus
Cognome: Lobrich
Email: send email
Telefono: +49 6151 167460
Fax: +49 6151 167462

DE (DARMSTADT) participant 396˙480.00
8    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Dr.
Nome: Panagiota
Cognome: Sotiropoulou
Email: send email
Telefono: +32 2 555 30 15
Fax: +32 2 555 46 55

BE (BRUXELLES) participant 391˙800.00
9    Nome Ente NON disponibile

 Organization address address: VIALE BENEDUCE 10
city: CASERTA
postcode: 81100

contact info
Titolo: Prof.
Nome: Umberto
Cognome: Galderisi
Email: send email
Telefono: 39815667585
Fax: 39815667547

IT (CASERTA) participant 344˙400.00
10    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022

DE (MUENCHEN) participant 294˙295.00
11    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Dr.
Nome: Phil
Cognome: Jones
Email: send email
Telefono: +44 1223 763379
Fax: +44 1223 763240

UK (SWINDON) participant 23˙251.00
12    HEALTH PROTECTION AGENCY HPA

 Organization address address: Central Office - 7th Floor, Holborn Gate - High Holborn 330
city: LONDON
postcode: WC1V 7PP

contact info
Titolo: Mrs.
Nome: Anne
Cognome: Dempsey
Email: send email
Telefono: +44 1235 825433
Fax: +44 1235 833891

UK (LONDON) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

stem    estimates    risk    responses    dose    origin    improving    scientific    doses    upon    cells    exposed    cancer    identification    radiation    extrapolation    cancers    lt    protection    biological    mechanistic    humans    tissue   

 Obiettivo del progetto (Objective)

'The magnitude of cancer risk in humans exposed to low radiation doses (<100mSv) is uncertain and depends upon extrapolation of human population based estimates obtained at higher doses. The linear non-threshold extrapolation model currently used has some support from mechanistic/biophysical considerations but it is not based on understanding of the biological responses of the cells of origin for radiation cancer. Stem cells are widely recognised as the cells of origin for many cancers. Understanding the responses of stem cells to low radiation doses will be important therefore in providing mechanistic support for low dose cancer risk extrapolation. In this project, techniques emerging from stem cell biological and tissue kinetics research will be used to address several major areas of uncertainty in low dose (<100 mGy) cancer risk estimates:

1. The identification and enumeration of stem/progenitor cells at risk 2. Understanding low dose radio-sensitivity of stem cells and tissues. 3. Improving understanding of mechanisms of age-dependant cancer risk 4. Improving understanding of tissue specific differences in cancer risk. 5. Identification of key events and individual susceptibility factors associated with cancer development.

The primary output of the RISK-IR project will be peer reviewed scientific papers. Considerable efforts will be made to consolidate scientific evidence of relevance for radiation protection through reviews and dissemination of project results and implications to radiation protection specialists will be facilitated through a stakeholder meeting in the final year of the project.'

Introduzione (Teaser)

Cancer risk in humans exposed to low radiation doses is usually calculated based upon estimates obtained at higher doses. As many cancers originate in stem cells, studying low dose radiation effects on these cells is particularly important.

Altri progetti dello stesso programma (FP7-EURATOM-FISSION)

ADVANCE (2011)

Ageing Diagnostics and Prognostics of low-voltage I&C cables

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DOREMI (2010)

Low Dose Research towards Multidisciplinary Integration

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RENEB (2012)

Realizing the European Network in Biodosimetry

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