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Cell line development platform for SMEs to reduce the length and cost of biologic drug development

Total Cost €


EC-Contrib. €






 IcoCell project word cloud

Explore the words cloud of the IcoCell project. It provides you a very rough idea of what is the project "IcoCell" about.

throughput    optimizing    factories    advantages    lines    2022    faster    industrial    platform    player    tools    burdening    expression    integration    demonstrating    commercialization    therapies    sensitive    26m    regulatory    2014    lack    rational    limiting    2021    penetrate    market    sites    healthcare    proteins    standard    grow    mean    billion    icf    types    biotech    drugs    expensive    creative    smes    generating    months    fewer    industry    cagr    200    protein    insertion    900m    screening    20x    biologic    robotic    compatible    indications    dependent    160    breakthrough    900    amplification    flexible    capital    cell       time    groups    initial    12    predefined    biotechnology    gt    documentation    develops    preparing    lower    mammalian    revenues    yield    icocell    facilities    outcomes    implementing    reduces    platforms    health    units    investment    therapeutic    stem    exceeds    of    landing    efficient    line    recombination   

Project "IcoCell" data sheet

The following table provides information about the project.


Organization address
address: EERIKA TEE 1
postcode: 61713
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Estonia [EE]
 Project website
 Total cost 1˙614˙000 €
 EC max contribution 1˙129˙800 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-2-2015
 Funding Scheme SME-2
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ICOSAGEN CELL FACTORY OU EE (KAMBJA VALD) coordinator 1˙129˙800.00


 Project objective

Biologic drugs ($160 billion market) provide better long-term health outcomes with fewer side effects than many traditional drugs. However, due to high development and production costs, these drugs are 20x more expensive, on average, limiting the access to these therapies and burdening healthcare systems. To a great extent, this is because traditionally flexible and creative biotech SMEs currently lack rational tools for mammalian cell line development (most of the biologic drugs are produced in mammalian cell lines), meaning that large investment in terms of capital and time is required to make a production cell line.

ICF, an established player in the biotechnology industry, develops a technology for more efficient development of mammalian cell lines for high-yield protein production. It reduces the need for robotic systems and high-throughput screening facilities (€900 000 -> €200 000), the time (6-12 months -> 3) and cost (€100 000 -> €50 000) of cell line development. These advantages stem from specific landing platforms, predefined integration sites, recombination-dependent insertion and amplification of expression units. The technology will enable biotech SMEs to develop the process of production of new biologic drugs at lower costs and faster, eventually enabling biologic drugs to penetrate more cost-sensitive indications and target groups.

IcoCell project is aimed at optimizing the landing platform, generating cell lines compatible with process of development of industrial cell factories, generating regulatory documentation, preparing standard operating procedures, demonstrating the production of different types of proteins and implementing initial exploitation activities.

Cell line development market is expected to grow at CAGR of 12.8% (2014-2022) and the market for cell line development to produce therapeutic proteins exceeds €900M. Commercialization of IcoCell technology will mean breakthrough for ICF, increasing revenues by an estimated €26M in 2021

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The information about "ICOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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