Opendata, web and dolomites


Characterizing Adaptation and Migration Events with Modern and Ancient Genomes

Total Cost €


EC-Contrib. €






Project "CAMERA" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 1˙498˙478 €
 EC max contribution 1˙498˙478 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 1˙498˙478.00


 Project objective

BACKGROUND Ancient DNA research has recently entered the genomics era. Performing “ancient population genomics” is now technically possible. Utilizing the temporal aspect of this new data, we can address fundamental evolutionary questions such as the amount of selection acting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding the molecular basis of human adaptation to high altitude and investigating the timing of the Polynesian-South American contact, (ii) develop statistical approaches that combine ancient and modern genetic data to estimate the timing and the intensity of a selective sweep and an admixture event. METHODOLOGY Application: We will collect, date and DNA sequence human remains. Combining the ancient genetic data, 14C dates with existing modern genomic data will allow us to increase the resolution as to the timing of the adaptive and the admixture event, respectively, while generating unique datasets. Theory: We will build on existing methods based on one-locus classical population genetic models to develop tools to analyse whole genome time serial data. RELEVANCE Ecological: The results will address the fundamental question of how much of the human genome is undergoing selection, better characterize one of the textbook examples of adaptation in humans and contribute to our understanding of the peopling of the Americas. Medical: We will gain insights into the fundamental stress physiology experienced at high altitude and therefore into altitude-related illnesses. Methodological: The methods developed in this project will not only benefit the growing field of ancient genomics but also other fields where data is collected in a temporal manner, such as experimental evolution and epidemiology


year authors and title journal last update
List of publications.
2018 J. Víctor Moreno-Mayar, Lasse Vinner, Peter de Barros Damgaard, Constanza de la Fuente, Jeffrey Chan, Jeffrey P. Spence, Morten E. Allentoft, Tharsika Vimala, Fernando Racimo, Thomaz Pinotti, Simon Rasmussen, Ashot Margaryan, Miren Iraeta Orbegozo, Dorothea Mylopotamitaki, Matthew Wooller, Clement Bataille, Lorena Becerra-Valdivia, David Chivall, Daniel Comeskey, Thibaut Devièse, Donald K. Grays
Early human dispersals within the Americas
published pages: eaav2621, ISSN: 0036-8075, DOI: 10.1126/science.aav2621
Science 362/6419 2019-08-05
2018 Saskia Wutke, Edson Sandoval-Castellanos, Norbert Benecke, Hans-Jürgen Döhle, Susanne Friederich, Javier Gonzalez, Michael Hofreiter, Lembi Lõugas, Ola Magnell, Anna-Sapfo Malaspinas, Arturo Morales-Muñiz, Ludovic Orlando, Monika Reissmann, Alexandra Trinks, Arne Ludwig
Decline of genetic diversity in ancient domestic stallions in Europe
published pages: eaap9691, ISSN: 2375-2548, DOI: 10.1126/sciadv.aap9691
Science Advances 4/4 2019-08-05
2018 Diana I. Cruz-Dávalos, María A. Nieves-Colón, Alexandra Sockell, G. David Poznik, Hannes Schroeder, Anne C. Stone, Carlos D. Bustamante, Anna-Sapfo Malaspinas, María C. Ávila-Arcos
In-solution Y-chromosome capture-enrichment on ancient DNA libraries
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4945-x
BMC Genomics 19/1 2019-08-05
2018 Constanza de la Fuente, María C. Ávila-Arcos, Jacqueline Galimany, Meredith L. Carpenter, Julian R. Homburger, Alejandro Blanco, Paloma Contreras, Diana Cruz Dávalos, Omar Reyes, Manuel San Roman, Andrés Moreno-Estrada, Paula F. Campos, Celeste Eng, Scott Huntsman, Esteban G. Burchard, Anna-Sapfo Malaspinas, Carlos D. Bustamante, Eske Willerslev, Elena Llop, Ricardo A. Verdugo, Mauricio Moraga
Genomic insights into the origin and diversification of late maritime hunter-gatherers from the Chilean Patagonia
published pages: E4006-E4012, ISSN: 0027-8424, DOI: 10.1073/pnas.1715688115
Proceedings of the National Academy of Sciences 115/17 2019-08-05
2018 Marcia S. Ponce de León, Toetik Koesbardiati, John David Weissmann, Marco Milella, Carlos S. Reyna-Blanco, Gen Suwa, Osamu Kondo, Anna-Sapfo Malaspinas, Tim D. White, Christoph P. E. Zollikofer
Human bony labyrinth is an indicator of population history and dispersal from Africa
published pages: 4128-4133, ISSN: 0027-8424, DOI: 10.1073/pnas.1717873115
Proceedings of the National Academy of Sciences 115/16 2019-08-05
2018 Joanne L. Wright, Sally Wasef, Tim H. Heupink, Michael C. Westaway, Simon Rasmussen, Colin Pardoe, Gudju Gudju Fourmile, Michael Young, Trish Johnson, Joan Slade, Roy Kennedy, Patsy Winch, Mary Pappin, Tapij Wales, William “Badger” Bates, Sharnie Hamilton, Neville Whyman, Sheila van Holst Pellekaan, Peter J. McAllister, Paul S.C. Taçon, Darren Curnoe, Ruiqiang Li, Craig Millar, Sankar Subrama
Ancient nuclear genomes enable repatriation of Indigenous human remains
published pages: eaau5064, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau5064
Science Advances 4/12 2019-08-05
2018 Hugh McColl, Fernando Racimo, Lasse Vinner, Fabrice Demeter, Takashi Gakuhari, J. Víctor Moreno-Mayar, George van Driem, Uffe Gram Wilken, Andaine Seguin-Orlando, Constanza de la Fuente Castro, Sally Wasef, Rasmi Shoocongdej, Viengkeo Souksavatdy, Thongsa Sayavongkhamdy, Mohd Mokhtar Saidin, Morten E. Allentoft, Takehiro Sato, Anna-Sapfo Malaspinas, Farhang A. Aghakhanian, Thorfinn Korneliussen,
The prehistoric peopling of Southeast Asia
published pages: 88-92, ISSN: 0036-8075, DOI: 10.1126/science.aat3628
Science 361/6397 2019-08-05

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