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Multimodal Imaging of Disorders of Consciousness

Total Cost €


EC-Contrib. €






 MIDOC project word cloud

Explore the words cloud of the MIDOC project. It provides you a very rough idea of what is the project "MIDOC" about.

neuroimaging    brain    alterations    proposing    underlying    scientific    proper    oscillations    neurophysiological    magnetic    competences    mechanism    spatial    manifestations    connectivity    secure    correlate    anatomical    decisions    gt    levels    establishing    fronto    parietal    signatures    plan    difficult    data    treatment    diffusion    breakdown    functional    emergence    complexity    transferable    emerged    techniques    conscious    percentage    palliative    tool    40    descriptions    measured    career    diminished    frequency    behavioural    anatomy    widen    relate    individuals    training    patients    invasive    implications    hypotheses    thalamo    imaging    life    researcher    degree    single    misdiagnosis    care    rhythms    tensor    resolutions    impairment    position    disorders    consciousness    simultaneously    cortical    skills    tools    neural    severity    integrating    synergy    disorder    fundamental    independent    limited    electroencephalography    description    prognosis    temporal    occurs    unknown    resonance    group    diagnosis   

Project "MIDOC" data sheet

The following table provides information about the project.


Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The diagnosis of individuals with disorders of consciousness has fundamental implications in terms of prognosis, treatment, palliative care and even proper end-of-life decisions. Diagnosis based on behavioural assessment is difficult and it is believed that misdiagnosis occurs in a large percentage of cases (> 40%). Non-invasive functional brain imaging has recently emerged as a promising tool for the diagnosis of individuals with disorders of consciousness; however, different imaging methods allow descriptions at limited spatial and temporal resolutions, and it is unknown how these findings relate to each other, to the underlying brain anatomy, and whether they are manifestations of a single fundamental mechanism underlying the impairment of conscious awareness.

The proposed research project aims to investigate individuals with disorders of consciousness by simultaneously applying these different neuroimaging techniques, thus integrating neurophysiological data across description levels and evaluating their synergy for the objective diagnosis and prognosis of patients. We address the hypotheses that alterations in brain rhythms (measured with electroencephalography) typical of individuals with disorders of consciousness (such as the emergence of low-complexity and low-frequency neural oscillations) are related to diminished fronto-parietal activity and a breakdown of thalamo-cortical functional and anatomical connectivity (functional magnetic resonance imaging; diffusion tensor imaging) and that these signatures of consciousness correlate with the severity of the disorder and the degree of conscious awareness of the patients.

In addition, we are proposing a career development plan for the applicant that includes training on scientific and transferable skills. This plan will both widen his scientific competences and provide him with the tools and experience necessary to secure a position as a leading independent researcher by establishing his own group.


year authors and title journal last update
List of publications.
2018 Federico Cavanna, Martina G. Vilas, Matías Palmucci, Enzo Tagliazucchi
Dynamic functional connectivity and brain metastability during altered states of consciousness
published pages: 383-395, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.09.065
NeuroImage 180 2020-01-29
2019 Charlotte Martial, Héléna Cassol, Vanessa Charland-Verville, Carla Pallavicini, Camila Sanz, Federico Zamberlan, Rocío Martínez Vivot, Fire Erowid, Earth Erowid, Steven Laureys, Bruce Greyson, Enzo Tagliazucchi
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports
published pages: 52-69, ISSN: 1053-8100, DOI: 10.1016/j.concog.2019.01.011
Consciousness and Cognition 69 2020-01-29
2018 Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid, Enzo Tagliazucchi
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
published pages: , ISSN: 1662-5145, DOI: 10.3389/fnint.2018.00054
Frontiers in Integrative Neuroscience 12 2020-01-29

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