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MIDOC

Multimodal Imaging of Disorders of Consciousness

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIDOC project word cloud

Explore the words cloud of the MIDOC project. It provides you a very rough idea of what is the project "MIDOC" about.

fronto    techniques    independent    emergence    neuroimaging    hypotheses    mechanism    descriptions    neural    cortical    anatomical    diffusion    synergy    invasive    description    measured    treatment    limited    difficult    signatures    occurs    skills    impairment    unknown    resonance    palliative    single    breakdown    correlate    thalamo    data    researcher    patients    functional    consciousness    frequency    scientific    diagnosis    tool    fundamental    individuals    diminished    relate    alterations    complexity    connectivity    40    severity    degree    secure    widen    parietal    establishing    training    position    tools    simultaneously    spatial    implications    brain    rhythms    imaging    anatomy    plan    integrating    behavioural    tensor    prognosis    emerged    life    percentage    proper    underlying    career    disorders    electroencephalography    resolutions    group    decisions    transferable    manifestations    proposing    gt    magnetic    temporal    disorder    neurophysiological    misdiagnosis    oscillations    competences    levels    conscious    care   

Project "MIDOC" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://icm-institute.org/en/team/team-bartolomeo-cohen-naccache/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

The diagnosis of individuals with disorders of consciousness has fundamental implications in terms of prognosis, treatment, palliative care and even proper end-of-life decisions. Diagnosis based on behavioural assessment is difficult and it is believed that misdiagnosis occurs in a large percentage of cases (> 40%). Non-invasive functional brain imaging has recently emerged as a promising tool for the diagnosis of individuals with disorders of consciousness; however, different imaging methods allow descriptions at limited spatial and temporal resolutions, and it is unknown how these findings relate to each other, to the underlying brain anatomy, and whether they are manifestations of a single fundamental mechanism underlying the impairment of conscious awareness.

The proposed research project aims to investigate individuals with disorders of consciousness by simultaneously applying these different neuroimaging techniques, thus integrating neurophysiological data across description levels and evaluating their synergy for the objective diagnosis and prognosis of patients. We address the hypotheses that alterations in brain rhythms (measured with electroencephalography) typical of individuals with disorders of consciousness (such as the emergence of low-complexity and low-frequency neural oscillations) are related to diminished fronto-parietal activity and a breakdown of thalamo-cortical functional and anatomical connectivity (functional magnetic resonance imaging; diffusion tensor imaging) and that these signatures of consciousness correlate with the severity of the disorder and the degree of conscious awareness of the patients.

In addition, we are proposing a career development plan for the applicant that includes training on scientific and transferable skills. This plan will both widen his scientific competences and provide him with the tools and experience necessary to secure a position as a leading independent researcher by establishing his own group.

 Publications

year authors and title journal last update
List of publications.
2018 Federico Cavanna, Martina G. Vilas, Matías Palmucci, Enzo Tagliazucchi
Dynamic functional connectivity and brain metastability during altered states of consciousness
published pages: 383-395, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2017.09.065
NeuroImage 180 2020-01-29
2019 Charlotte Martial, Héléna Cassol, Vanessa Charland-Verville, Carla Pallavicini, Camila Sanz, Federico Zamberlan, Rocío Martínez Vivot, Fire Erowid, Earth Erowid, Steven Laureys, Bruce Greyson, Enzo Tagliazucchi
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports
published pages: 52-69, ISSN: 1053-8100, DOI: 10.1016/j.concog.2019.01.011
Consciousness and Cognition 69 2020-01-29
2018 Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Carla Pallavicini, Fire Erowid, Earth Erowid, Enzo Tagliazucchi
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
published pages: , ISSN: 1662-5145, DOI: 10.3389/fnint.2018.00054
Frontiers in Integrative Neuroscience 12 2020-01-29

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