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MYCLASS SIGNED

Towards prevention, early diagnosis, and noninvasive treatment of uterine leiomyomas through molecular classification

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MYCLASS project word cloud

Explore the words cloud of the MYCLASS project. It provides you a very rough idea of what is the project "MYCLASS" about.

driving    every    women    effect    fibroids    excessive    create    diagnosis    clues    wall    tumors    hereditary    detection    molecular    copy    variation    class    somewhat    describe    subclasses    anticipate    throughput    expression    fourth    examine    integration    layers    invasive    biological    erc    leiomyomas    premenopausal    benign    uls    clinicopathologically    routine    compounds    variants    pain    gene    health    woman    genome    stratified    ul    susceptibility    drugs    predisposition    existence    mechanism    shed    hysterectomy    tools    suffers    abdominal    lay    clinicopathological    data    considering    smooth    infertility    muscle    basis    symptoms    hypotheses    uterine    understudied    sequence    tumor    contributes    genetic    mechanisms    methylome    biology    millions    hypothesize    confer    subclass    benefit    multiple    life    reaching    point    emerge    breakthrough    profiles    biomarkers    light    severely    scientific    burden    predisposing    genesis    myomas    treatment    hundreds    classification    efforts    substantial    bleeding   

Project "MYCLASS" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 2˙499˙099 €
 EC max contribution 2˙499˙099 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 2˙499˙099.00

Map

 Project objective

Every fourth woman suffers from uterine leiomyomas (ULs) – benign tumors of the uterine smooth muscle wall - at some point in premenopausal life. ULs, also called myomas or fibroids, cause a substantial health burden through symptoms such as excessive uterine bleeding, abdominal pain and infertility. These tumors are the most common cause of hysterectomy. Considering the impact that ULs have to women’s health, they are severely understudied. Our breakthrough work has shed important new light on the biology and genesis of ULs. In this ERC proposal we hypothesize that ULs can emerge through several distinct mechanisms and anticipate that each mechanism contributes to somewhat different tumor biology, clinicopathological features, and response to treatment. Also, we hypothesize that predisposing genetic variants may confer susceptibility to a particular UL subclass. To test these hypotheses, we shall create multiple layers of high-throughput data on clinicopathologically characterized ULs, including copy number variation, whole genome sequence, gene expression, and methylome profiles. Integration of these data should establish the existence and key characteristics of the different UL subclasses. Finally, we shall examine the effect of currently used drugs as well as new lead compounds in response to treatment, stratified per UL subclass. These efforts will 1) provide biological insight into molecular mechanisms driving the UL genesis and lay the scientific basis of their molecular classification, 2) describe the key characteristics of each class, 3) provide key biomarkers and molecular tools for routine diagnosis of UL subclasses, as well as clues to their targeted treatment, and 4) produce tools for detection of hereditary predisposition to ULs. This ERC project will be an important step towards non-invasive management of ULs. Reaching this goal would benefit hundreds of millions of women.

 Publications

year authors and title journal last update
List of publications.
2018 Riku Katainen, Iikki Donner, Tatiana Cajuso, Eevi Kaasinen, Kimmo Palin, Veli Mäkinen, Lauri A. Aaltonen, Esa Pitkänen
Discovery of potential causative mutations in human coding and noncoding genome with the interactive software BasePlayer
published pages: 2580-2600, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0052-3
Nature Protocols 13/11 2019-10-29
2018 Riku Katainen, Iikki Donner, Tatiana Cajuso, Eevi Kaasinen, Kimmo Palin, Veli Mäkinen, Lauri A. Aaltonen, Esa Pitkänen
Discovery of potential causative mutations in human coding and noncoding genome with the interactive software BasePlayer
published pages: 2580-2600, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0052-3
Nature Protocols 13/11 2019-06-13
2018 Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen
Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37110
eLife 7 2019-06-13
2018 Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen
Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37110
eLife 7 2019-05-25

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