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MYCLASS SIGNED

Towards prevention, early diagnosis, and noninvasive treatment of uterine leiomyomas through molecular classification

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MYCLASS project word cloud

Explore the words cloud of the MYCLASS project. It provides you a very rough idea of what is the project "MYCLASS" about.

data    existence    understudied    diagnosis    classification    substantial    genome    somewhat    burden    examine    genetic    genesis    clinicopathological    layers    variation    shed    tools    basis    muscle    benign    invasive    hypothesize    bleeding    symptoms    subclasses    severely    predisposing    profiles    variants    copy    biology    mechanisms    sequence    light    considering    scientific    leiomyomas    suffers    life    tumor    myomas    hereditary    hypotheses    excessive    woman    expression    point    integration    methylome    throughput    millions    describe    health    premenopausal    women    tumors    benefit    ul    fibroids    effect    anticipate    susceptibility    create    pain    wall    efforts    smooth    driving    compounds    uls    drugs    infertility    clues    contributes    uterine    subclass    biomarkers    abdominal    lay    mechanism    multiple    detection    stratified    erc    treatment    biological    gene    hundreds    emerge    class    fourth    molecular    routine    predisposition    every    hysterectomy    confer    breakthrough    reaching    clinicopathologically   

Project "MYCLASS" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 2˙499˙099 €
 EC max contribution 2˙499˙099 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 2˙499˙099.00

Map

 Project objective

Every fourth woman suffers from uterine leiomyomas (ULs) – benign tumors of the uterine smooth muscle wall - at some point in premenopausal life. ULs, also called myomas or fibroids, cause a substantial health burden through symptoms such as excessive uterine bleeding, abdominal pain and infertility. These tumors are the most common cause of hysterectomy. Considering the impact that ULs have to women’s health, they are severely understudied. Our breakthrough work has shed important new light on the biology and genesis of ULs. In this ERC proposal we hypothesize that ULs can emerge through several distinct mechanisms and anticipate that each mechanism contributes to somewhat different tumor biology, clinicopathological features, and response to treatment. Also, we hypothesize that predisposing genetic variants may confer susceptibility to a particular UL subclass. To test these hypotheses, we shall create multiple layers of high-throughput data on clinicopathologically characterized ULs, including copy number variation, whole genome sequence, gene expression, and methylome profiles. Integration of these data should establish the existence and key characteristics of the different UL subclasses. Finally, we shall examine the effect of currently used drugs as well as new lead compounds in response to treatment, stratified per UL subclass. These efforts will 1) provide biological insight into molecular mechanisms driving the UL genesis and lay the scientific basis of their molecular classification, 2) describe the key characteristics of each class, 3) provide key biomarkers and molecular tools for routine diagnosis of UL subclasses, as well as clues to their targeted treatment, and 4) produce tools for detection of hereditary predisposition to ULs. This ERC project will be an important step towards non-invasive management of ULs. Reaching this goal would benefit hundreds of millions of women.

 Publications

year authors and title journal last update
List of publications.
2018 Riku Katainen, Iikki Donner, Tatiana Cajuso, Eevi Kaasinen, Kimmo Palin, Veli Mäkinen, Lauri A. Aaltonen, Esa Pitkänen
Discovery of potential causative mutations in human coding and noncoding genome with the interactive software BasePlayer
published pages: 2580-2600, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0052-3
Nature Protocols 13/11 2019-10-29
2018 Riku Katainen, Iikki Donner, Tatiana Cajuso, Eevi Kaasinen, Kimmo Palin, Veli Mäkinen, Lauri A. Aaltonen, Esa Pitkänen
Discovery of potential causative mutations in human coding and noncoding genome with the interactive software BasePlayer
published pages: 2580-2600, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0052-3
Nature Protocols 13/11 2019-06-13
2018 Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen
Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37110
eLife 7 2019-06-13
2018 Niko Välimäki, Heli Kuisma, Annukka Pasanen, Oskari Heikinheimo, Jari Sjöberg, Ralf Bützow, Nanna Sarvilinna, Hanna-Riikka Heinonen, Jaana Tolvanen, Simona Bramante, Tomas Tanskanen, Juha Auvinen, Outi Uimari, Amjad Alkodsi, Rainer Lehtonen, Eevi Kaasinen, Kimmo Palin, Lauri A Aaltonen
Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37110
eLife 7 2019-05-25

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