Explore the words cloud of the EpiMech project. It provides you a very rough idea of what is the project "EpiMech" about.
The following table provides information about the project.
UNIVERSITAT POLITECNICA DE CATALUNYA
|Coordinator Country||Spain [ES]|
|Total cost||1˙989˙875 €|
|EC max contribution||1˙989˙875 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
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|1||UNIVERSITAT POLITECNICA DE CATALUNYA||ES (BARCELONA)||coordinator||1˙989˙875.00|
The epithelium is a cohesive two-dimensional layer of cells attached to a fluid-filled fibrous matrix, which lines most free surfaces and cavities of the body. It serves as a protective barrier with tunable permeability, which must retain integrity in a mechanically active environment. Paradoxically, it must also be malleable enough to self-heal and remodel into functional 3D structures such as villi in our guts or tubular networks. Intrigued by these conflicting material properties, the main idea of this proposal is to view epithelial monolayers as living engineering materials. Unlike lipid bilayers or hydrogels, widely used in biotechnology, cultured epithelia are only starting to be integrated in organ-on-chip microdevices. As for any complex inert material, this program requires a fundamental understanding of the structure-property relationships. (1) Regarding their effective in-plane rheology, at short time-scales epithelia exhibit solid-like behavior while at longer times they flow as a consequence of the only qualitatively understood dynamics of the cell-cell junctional network. (2) As for material failure, excessive tension can lead to epithelial fracture, but as we have recently shown, matrix poroelasticity can also cause hydraulic fracture under stretch. However, it is largely unknown how adhesion molecules, membrane, cytoskeleton and matrix interact to give epithelia their robust and flaw-tolerant resilience. (3) Regarding shaping 3D epithelial structures, besides the classical view of chemical patterning, mechanical buckling is emerging as a major morphogenetic driving force, suggesting that it may be possible design 3D epithelial structures in vitro by mechanical self-assembly. Towards understanding (1,2,3), we will combine a broad range of theoretical, computational and experimental methods. Besides providing fundamental mechanobiological understanding, this project will provide a framework to manipulate epithelia in bioinspired technologies.
|year||authors and title||journal||last update|
Marino Arroyo, Xavier Trepat
published pages: 442-443, ISSN: 0036-8075, DOI: 10.1126/science.aay2860
Caterina Tozzi, Nikhil Walani, Marino Arroyo
Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins
published pages: 93004, ISSN: 1367-2630, DOI: 10.1088/1367-2630/ab3ad6
|New Journal of Physics 21/9||2020-04-08|
Alejandro Torres-SÃ¡nchez, Juan M. Vanegas, Prashant K. Purohit, Marino Arroyo
Combined molecular/continuum modeling reveals the role of friction during fast unfolding of coiled-coil proteins
published pages: 4961-4975, ISSN: 1744-683X, DOI: 10.1039/c9sm00117d
|Soft Matter 15/24||2020-04-08|
Marino Arroyo, Xavier Trepat
Hydraulic fracturing in cells and tissues: fracking meets cell biology
published pages: 1-6, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2016.11.001
|Current Opinion in Cell Biology 44||2020-04-08|
Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-Cusachs
The plasma membrane as a mechanochemical transducer
published pages: , ISSN: 0962-8436, DOI:
|Philosophical Transactions B accepted||2020-04-08|
A theoretical and computational study of soft adhesion mediated by mobile binders
published pages: , ISSN: , DOI:
Alejandro Torres-SÃ¡nchez, Daniel MillÃ¡n, Marino Arroyo
Modelling fluid deformable surfaces with an emphasis on biological interfaces
published pages: , ISSN: 0022-1120, DOI:
|Journal of Fluid Mechanics accepted||2020-04-08|
Bin Li, Daniel MillÃ¡n, Alejandro Torres-SÃ¡nchez, BenoÃ®t Roman, Marino Arroyo
A variational model of fracture for tearing brittle thin sheets
published pages: 334-348, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2018.06.022
|Journal of the Mechanics and Physics of Solids 119||2020-04-08|
Ernest Latorre, Sohan Kale, Laura Casares, Manuel GÃ³mez-GonzÃ¡lez, Marina Uroz, LÃ©o Valon, Roshna V. Nair, Elena Garreta, Nuria Montserrat, ArÃ¡nzazu del Campo, Benoit Ladoux, Marino Arroyo, Xavier Trepat
Active superelasticity in three-dimensional epithelia of controlled shape
published pages: 203-208, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0671-4
Giovanni Noselli, Alfred Beran, Marino Arroyo, Antonio DeSimone
Swimming Euglena respond to confinement with a behavioural change enabling effective crawling
published pages: , ISSN: 1745-2473, DOI: 10.1038/s41567-019-0425-8
Giovanni Noselli, Marino Arroyo, Antonio DeSimone
Smart helical structures inspired by the pellicle of euglenids
published pages: 234-246, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2018.09.036
|Journal of the Mechanics and Physics of Solids 123||2020-04-08|
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