Explore the words cloud of the CentrioleBirthDeath project. It provides you a very rough idea of what is the project "CentrioleBirthDeath" about.
The following table provides information about the project.
FUNDACAO CALOUSTE GULBENKIAN
|Coordinator Country||Portugal [PT]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||FUNDACAO CALOUSTE GULBENKIAN||PT (LISBOA)||coordinator||2˙000˙000.00|
Centrioles assemble centrosomes and cilia/flagella, critical structures for cell division, polarity, motility and signalling, which are often deregulated in human disease. Centriole inheritance, in particular the preservation of their copy number and position in the cell is critical in many eukaryotes. I propose to investigate, in an integrative and quantitative way, how centrioles are formed in the right numbers at the right time and place, and how they are maintained to ensure their function and inheritance. We first ask how centrioles guide their own assembly position and centriole copy number. Our recent work highlighted several properties of the system, including positive and negative feedbacks and spatial cues. We explore critical hypotheses through a combination of biochemistry, quantitative live cell microscopy and computational modelling. We then ask how the centrosome and the cell cycle are both coordinated. We recently identified the triggering event in centriole biogenesis and how its regulation is akin to cell cycle control of DNA replication and centromere assembly. We will explore new hypotheses to understand how assembly time is coupled to the cell cycle. Lastly, we ask how centriole maintenance is regulated. By studying centriole disappearance in the female germline we uncovered that centrioles need to be actively maintained by their surrounding matrix. We propose to investigate how that matrix provides stability to the centrioles, whether this is differently regulated in different cell types and the possible consequences of its misregulation for the organism (infertility and ciliopathy-like symptoms). We will take advantage of several experimental systems (in silico, ex-vivo, flies and human cells), tailoring the assay to the question and allowing for comparisons across experimental systems to provide a deeper understanding of the process and its regulation.
|year||authors and title||journal||last update|
Susana Montenegro Gouveia, Sihem Zitouni, Dong Kong, Paulo Duarte, Beatriz Ferreira Gomes, Ana Laura Sousa, Erin M. Tranfield, Anthony Hyman, Jadranka Loncarek, Monica Bettencourt-Dias
PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation
published pages: jcs219501, ISSN: 0021-9533, DOI: 10.1242/jcs.219501
|Journal of Cell Science 132/4||2019-08-29|
Sascha Werner, Ana Pimenta-Marques, MÃ³nica Bettencourt-Dias
Maintaining centrosomes and cilia
published pages: 3789-3800, ISSN: 0021-9533, DOI: 10.1242/jcs.203505
|Journal of Cell Science 130/22||2019-09-05|
Daisuke Ito, Sihem Zitouni, Swadhin Chandra Jana, Paulo Duarte, Jaroslaw Surkont, Zita Carvalho-Santos, JosÃ© B Pereira-Leal, Miguel Godinho Ferreira, MÃ³nica Bettencourt-Dias
Pericentrin-mediated SAS-6 recruitment promotes centriole assembly
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.41418
Swadhin Chandra Jana, Susana MendonÃ§a, Pedro Machado, Sascha Werner, Jaqueline Rocha, AntÃ³nio Pereira, Helder Maiato, MÃ³nica Bettencourt-Dias
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity
published pages: 928-941, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0132-1
|Nature Cell Biology 20/8||2019-08-29|
Catarina Nabais, SÃ³nia Gomes Pereira, MÃ³nica Bettencourt-Dias
Noncanonical Biogenesis of Centrioles and Basal Bodies
published pages: 123-135, ISSN: 0091-7451, DOI: 10.1101/sqb.2017.82.034694
|Cold Spring Harbor Symposia on Quantitative Biology 82||2019-09-05|
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