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CentrioleBirthDeath SIGNED

Mechanism of centriole inheritance and maintenance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CentrioleBirthDeath project word cloud

Explore the words cloud of the CentrioleBirthDeath project. It provides you a very rough idea of what is the project "CentrioleBirthDeath" about.

female    dna    cells    deeper    cycle    biochemistry    disappearance    polarity    negative    first    understand    symptoms    event    motility    combination    right    provides    germline    assay    microscopy    formed    stability    silico    centrosomes    cues    computational    time    replication    positive    akin    coordinated    ciliopathy    regulated    assemble    hypotheses    deregulated    place    vivo    explore    surrounding    cell    highlighted    tailoring    cilia    function    centrosome    eukaryotes    structures    critical    differently    quantitative    question    spatial    preservation    advantage    misregulation    uncovered    position    experimental    coupled    inheritance    regulation    integrative    matrix    biogenesis    disease    maintained    maintenance    infertility    guide    live    centrioles    centriole    lastly    centromere    actively    signalling    organism    flagella    assembly    ex    division    copy    types    feedbacks    flies    comparisons    human    ask   

Project "CentrioleBirthDeath" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 2˙000˙000.00

Map

 Project objective

Centrioles assemble centrosomes and cilia/flagella, critical structures for cell division, polarity, motility and signalling, which are often deregulated in human disease. Centriole inheritance, in particular the preservation of their copy number and position in the cell is critical in many eukaryotes. I propose to investigate, in an integrative and quantitative way, how centrioles are formed in the right numbers at the right time and place, and how they are maintained to ensure their function and inheritance. We first ask how centrioles guide their own assembly position and centriole copy number. Our recent work highlighted several properties of the system, including positive and negative feedbacks and spatial cues. We explore critical hypotheses through a combination of biochemistry, quantitative live cell microscopy and computational modelling. We then ask how the centrosome and the cell cycle are both coordinated. We recently identified the triggering event in centriole biogenesis and how its regulation is akin to cell cycle control of DNA replication and centromere assembly. We will explore new hypotheses to understand how assembly time is coupled to the cell cycle. Lastly, we ask how centriole maintenance is regulated. By studying centriole disappearance in the female germline we uncovered that centrioles need to be actively maintained by their surrounding matrix. We propose to investigate how that matrix provides stability to the centrioles, whether this is differently regulated in different cell types and the possible consequences of its misregulation for the organism (infertility and ciliopathy-like symptoms). We will take advantage of several experimental systems (in silico, ex-vivo, flies and human cells), tailoring the assay to the question and allowing for comparisons across experimental systems to provide a deeper understanding of the process and its regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Susana Montenegro Gouveia, Sihem Zitouni, Dong Kong, Paulo Duarte, Beatriz Ferreira Gomes, Ana Laura Sousa, Erin M. Tranfield, Anthony Hyman, Jadranka Loncarek, Monica Bettencourt-Dias
PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation
published pages: jcs219501, ISSN: 0021-9533, DOI: 10.1242/jcs.219501
Journal of Cell Science 132/4 2019-08-29
2017 Sascha Werner, Ana Pimenta-Marques, Mónica Bettencourt-Dias
Maintaining centrosomes and cilia
published pages: 3789-3800, ISSN: 0021-9533, DOI: 10.1242/jcs.203505
Journal of Cell Science 130/22 2019-09-05
2019 Daisuke Ito, Sihem Zitouni, Swadhin Chandra Jana, Paulo Duarte, Jaroslaw Surkont, Zita Carvalho-Santos, José B Pereira-Leal, Miguel Godinho Ferreira, Mónica Bettencourt-Dias
Pericentrin-mediated SAS-6 recruitment promotes centriole assembly
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.41418
eLife 8 2019-08-29
2018 Swadhin Chandra Jana, Susana Mendonça, Pedro Machado, Sascha Werner, Jaqueline Rocha, António Pereira, Helder Maiato, Mónica Bettencourt-Dias
Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity
published pages: 928-941, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0132-1
Nature Cell Biology 20/8 2019-08-29
2017 Catarina Nabais, Sónia Gomes Pereira, Mónica Bettencourt-Dias
Noncanonical Biogenesis of Centrioles and Basal Bodies
published pages: 123-135, ISSN: 0091-7451, DOI: 10.1101/sqb.2017.82.034694
Cold Spring Harbor Symposia on Quantitative Biology 82 2019-09-05

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