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C.NAPSE SIGNED

TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDING AT THE SYNAPSE

Total Cost €

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EC-Contrib. €

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Partnership

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 C.NAPSE project word cloud

Explore the words cloud of the C.NAPSE project. It provides you a very rough idea of what is the project "C.NAPSE" about.

intracellular    strategy    genetics    specifies    series    pathological    aging    nanoscale    light    physiological    appear    vivo    electron    unforeseen    implementing    tractable    function    secreted    gaba    combination    organization    neuromuscular    molecules    extracellular    motoneurons    decline    functional    candidate    cutting    imaging    screens    acetylcholine    versus    mechanisms    pursue    lifetime    possibility    neurotransmitter    synaptic    conserved    protein    evolutionarily    decipher    correlative    innovative    gene    contribution    inhibitory    receptors    visualization    cell    outside    demonstrated    advantage    animals    shape    postsynaptic    behavior    analyze    complementary    levels    anticipate    microscopy    super    abundance    resolution    worms    localization    molecular    single    resolutive    identity    life    living    edge    powerful    synapses    transfer    genetic    synaptomatrix    fluorescent    proteins    regulate    entire    characterization    direct    paradigm    electrophysiology    domains    synapse    dynamic    scaffolds    genes    organize    scaffolding    excitatory    perform    particle    genetically    tracking    spatial    elegans    follow    maintenance    normal   

Project "C.NAPSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙492˙750 €
 EC max contribution 2˙492˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 2˙492˙750.00

Map

 Project objective

Synaptic scaffolding molecules control the localization and the abundance of neurotransmitter receptors at the synapse, a key parameter to shape synaptic transfer function. Most characterized synaptic scaffolds are intracellular, yet a growing number of secreted proteins appear to organize the synapse from the outside of the cell. We recently demonstrated in C. elegans that an evolutionarily conserved protein secreted by motoneurons specifies the excitatory versus inhibitory identity of the postsynaptic domains at neuromuscular synapses. We propose to use this system as a genetically tractable paradigm to perform a comprehensive characterization of this unforeseen synaptic organization. Specifically, this project will pursue 4 complementary aims: 1) Identify and characterize a comprehensive set of genes that organize and control the formation and maintenance of these scaffolds through a series of genetic screens based on the direct visualization of fluorescent acetylcholine and GABA receptors in living animals. 2) Solve the spatial synaptic organization of these scaffolds at a nanoscale resolution using super-resolutive and correlative light and electron microscopy, and analyze their dynamic behavior in vivo by implementing Single Particle Tracking imaging in living worms. 3) Decipher the role of the synaptomatrix in the organization of synaptic extracellular scaffolds and evaluate its functional contribution at the physiological and molecular levels using a candidate gene strategy and innovative imaging. 4) Analyze the formation and decline of these scaffolds at the lifetime scale and evaluate the role of synaptic activity and aging in these processes by taking advantage of the possibility to follow identified synapses over the entire life of C. elegans. Using powerful genetics in combination with cutting-edge in vivo imaging and electrophysiology, we anticipate to identify new genes and new mechanisms at work to regulate normal and pathological synaptic function.

 Publications

year authors and title journal last update
List of publications.
2018 Adeline Mergoud dit Lamarche, Laurent Molin, Laura Pierson, Marie-Christine Mariol, Jean-Louis Bessereau, Kathrin Gieseler, Florence Solari
UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans
published pages: e12713, ISSN: 1474-9718, DOI: 10.1111/acel.12713
Aging Cell 17/2 2019-10-28

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