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C.NAPSE SIGNED

TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDING AT THE SYNAPSE

Total Cost €

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EC-Contrib. €

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Partnership

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 C.NAPSE project word cloud

Explore the words cloud of the C.NAPSE project. It provides you a very rough idea of what is the project "C.NAPSE" about.

perform    particle    paradigm    cutting    powerful    gaba    microscopy    synapse    synaptomatrix    strategy    elegans    pathological    scaffolds    imaging    synapses    extracellular    cell    transfer    neuromuscular    organization    animals    scaffolding    innovative    normal    genetic    worms    entire    intracellular    inhibitory    localization    appear    postsynaptic    secreted    specifies    characterization    living    mechanisms    single    gene    conserved    follow    contribution    decline    combination    analyze    molecular    neurotransmitter    motoneurons    visualization    light    spatial    receptors    protein    domains    evolutionarily    fluorescent    abundance    organize    dynamic    genes    excitatory    versus    physiological    acetylcholine    synaptic    advantage    genetically    proteins    tractable    levels    identity    anticipate    super    function    shape    behavior    life    demonstrated    pursue    unforeseen    maintenance    functional    correlative    electron    vivo    genetics    series    lifetime    molecules    implementing    direct    complementary    electrophysiology    nanoscale    candidate    resolutive    regulate    aging    screens    possibility    tracking    decipher    edge    resolution    outside   

Project "C.NAPSE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙492˙750 €
 EC max contribution 2˙492˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 2˙492˙750.00

Map

 Project objective

Synaptic scaffolding molecules control the localization and the abundance of neurotransmitter receptors at the synapse, a key parameter to shape synaptic transfer function. Most characterized synaptic scaffolds are intracellular, yet a growing number of secreted proteins appear to organize the synapse from the outside of the cell. We recently demonstrated in C. elegans that an evolutionarily conserved protein secreted by motoneurons specifies the excitatory versus inhibitory identity of the postsynaptic domains at neuromuscular synapses. We propose to use this system as a genetically tractable paradigm to perform a comprehensive characterization of this unforeseen synaptic organization. Specifically, this project will pursue 4 complementary aims: 1) Identify and characterize a comprehensive set of genes that organize and control the formation and maintenance of these scaffolds through a series of genetic screens based on the direct visualization of fluorescent acetylcholine and GABA receptors in living animals. 2) Solve the spatial synaptic organization of these scaffolds at a nanoscale resolution using super-resolutive and correlative light and electron microscopy, and analyze their dynamic behavior in vivo by implementing Single Particle Tracking imaging in living worms. 3) Decipher the role of the synaptomatrix in the organization of synaptic extracellular scaffolds and evaluate its functional contribution at the physiological and molecular levels using a candidate gene strategy and innovative imaging. 4) Analyze the formation and decline of these scaffolds at the lifetime scale and evaluate the role of synaptic activity and aging in these processes by taking advantage of the possibility to follow identified synapses over the entire life of C. elegans. Using powerful genetics in combination with cutting-edge in vivo imaging and electrophysiology, we anticipate to identify new genes and new mechanisms at work to regulate normal and pathological synaptic function.

 Publications

year authors and title journal last update
List of publications.
2018 Adeline Mergoud dit Lamarche, Laurent Molin, Laura Pierson, Marie-Christine Mariol, Jean-Louis Bessereau, Kathrin Gieseler, Florence Solari
UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans
published pages: e12713, ISSN: 1474-9718, DOI: 10.1111/acel.12713
Aging Cell 17/2 2019-10-28

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