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Molecular organization and dynamics of synapse diversity: novel genetic, imaging and computational approaches

Total Cost €


EC-Contrib. €






 SYNNOVATE project word cloud

Explore the words cloud of the SYNNOVATE project. It provides you a very rough idea of what is the project "SYNNOVATE" about.

quantification    animals    architecture    almost    memory    led    hundreds    single    plasticity    radically    goals    mapping    schizophrenia    central    markers    molecular    functionalities    reorganised    cognitive    regions    measured    mutations    temporal    statistically    individual    brain    image    routine    discovery    diversity    mouse    learning    charts    understand    remarkable    imaging    distribute    reorganized    normal    synapses    organisation    label    arising    hallmark    maps    engrams    proteins    spatial    anatomical    electrophysiological    genetically    community    dependent    multiple    examine    autism    map    synapse    neuroanatomical    robustly    combinations    stimulation    genetic    disorders    diseases    tools    billion    encoded    recognition    reorganisation    links    synaptic    intellectual    tracing    disability    disorder    synaptome    revealed    catalogues    shown    plan    complexity    discovered    aetiology    computational    rapid    vertebrate    uncovered    progression    expression    differential    vast    generates    platform    showing    causing   

Project "SYNNOVATE" data sheet

The following table provides information about the project.


Organization address
postcode: EH8 9YL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 2˙000˙000.00


 Project objective

Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases. The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses. This has led to the recognition that “synaptome mapping” needs to be developed where the expression level of individual proteins is robustly measured in individual synapses across the whole brain. We developed a novel and unique ‘synaptome discovery and imaging platform’ that links the molecular organisation of synapses with the spatial and temporal anatomical diversity of individual synapses and charts molecular synaptome maps across the brain. This platform enables routine and rapid quantification of genetically encoded molecular markers, with multiple functionalities, in almost a billion synapses in hundreds of brain regions of the mouse and generates statistically robust synapse catalogues and molecular maps of the brain. We have uncovered remarkable new neuroanatomical features and revealed a synaptic molecular architecture at the systems-wide scale. We have discovered this architecture is radically reorganised by mutations that cause schizophrenia, intellectual disability and autism. We have also shown these new methods can label activity-dependent reorganisation of single synapses at a whole brain scale, enabling the tracing of synaptic memory engrams. Our goals are to understand how synaptome maps develop and are reorganized by mutations causing cognitive disorders; examine experience-dependent map plasticity during development, following learning and electrophysiological stimulation in normal animals and those carrying cognitive disorder mutations. We also plan to develop computational approaches based on synaptome maps and freely distribute genetic and image analysis tools to promote synaptome mapping in the community.


year authors and title journal last update
List of publications.
2018 Fei Zhu, Mélissa Cizeron, Zhen Qiu, Ruth Benavides-Piccione, Maksym V. Kopanitsa, Nathan G. Skene, Babis Koniaris, Javier DeFelipe, Erik Fransén, Noboru H. Komiyama, Seth G.N. Grant
Architecture of the Mouse Brain Synaptome
published pages: 781-799, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.07.007
Neuron 99 2020-03-20

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