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SYNNOVATE SIGNED

Molecular organization and dynamics of synapse diversity: novel genetic, imaging and computational approaches

Total Cost €

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EC-Contrib. €

0

Partnership

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 SYNNOVATE project word cloud

Explore the words cloud of the SYNNOVATE project. It provides you a very rough idea of what is the project "SYNNOVATE" about.

individual    label    electrophysiological    disorder    brain    tracing    complexity    autism    plasticity    routine    robustly    spatial    single    central    expression    intellectual    rapid    reorganisation    functionalities    animals    markers    links    mapping    genetically    computational    map    radically    encoded    synapse    genetic    generates    tools    reorganised    stimulation    shown    reorganized    recognition    arising    quantification    plan    synapses    molecular    revealed    combinations    diversity    community    diseases    differential    hundreds    catalogues    remarkable    image    dependent    billion    understand    charts    measured    discovery    showing    disorders    multiple    hallmark    neuroanatomical    regions    examine    progression    mouse    almost    engrams    distribute    causing    vertebrate    normal    goals    vast    mutations    imaging    synaptic    platform    discovered    proteins    uncovered    memory    aetiology    schizophrenia    maps    led    organisation    disability    synaptome    learning    statistically    cognitive    anatomical    temporal    architecture   

Project "SYNNOVATE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://synaptome.genes2cognition.org/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 2˙000˙000.00

Map

 Project objective

Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases. The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses. This has led to the recognition that “synaptome mapping” needs to be developed where the expression level of individual proteins is robustly measured in individual synapses across the whole brain. We developed a novel and unique ‘synaptome discovery and imaging platform’ that links the molecular organisation of synapses with the spatial and temporal anatomical diversity of individual synapses and charts molecular synaptome maps across the brain. This platform enables routine and rapid quantification of genetically encoded molecular markers, with multiple functionalities, in almost a billion synapses in hundreds of brain regions of the mouse and generates statistically robust synapse catalogues and molecular maps of the brain. We have uncovered remarkable new neuroanatomical features and revealed a synaptic molecular architecture at the systems-wide scale. We have discovered this architecture is radically reorganised by mutations that cause schizophrenia, intellectual disability and autism. We have also shown these new methods can label activity-dependent reorganisation of single synapses at a whole brain scale, enabling the tracing of synaptic memory engrams. Our goals are to understand how synaptome maps develop and are reorganized by mutations causing cognitive disorders; examine experience-dependent map plasticity during development, following learning and electrophysiological stimulation in normal animals and those carrying cognitive disorder mutations. We also plan to develop computational approaches based on synaptome maps and freely distribute genetic and image analysis tools to promote synaptome mapping in the community.

 Publications

year authors and title journal last update
List of publications.
2018 Fei Zhu, Mélissa Cizeron, Zhen Qiu, Ruth Benavides-Piccione, Maksym V. Kopanitsa, Nathan G. Skene, Babis Koniaris, Javier DeFelipe, Erik Fransén, Noboru H. Komiyama, Seth G.N. Grant
Architecture of the Mouse Brain Synaptome
published pages: 781-799, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.07.007
Neuron 99 2020-03-20

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