Opendata, web and dolomites

SYNNOVATE SIGNED

Molecular organization and dynamics of synapse diversity: novel genetic, imaging and computational approaches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SYNNOVATE project word cloud

Explore the words cloud of the SYNNOVATE project. It provides you a very rough idea of what is the project "SYNNOVATE" about.

electrophysiological    reorganized    generates    led    single    causing    differential    rapid    organisation    architecture    goals    cognitive    links    mouse    engrams    plan    genetic    examine    genetically    disorder    almost    functionalities    encoded    intellectual    computational    proteins    statistically    temporal    memory    mutations    imaging    autism    molecular    remarkable    synapses    routine    disability    plasticity    tracing    showing    brain    progression    stimulation    discovered    aetiology    uncovered    vast    radically    arising    reorganised    measured    combinations    label    synaptic    billion    learning    regions    recognition    vertebrate    hallmark    distribute    image    hundreds    reorganisation    dependent    quantification    diversity    tools    map    animals    expression    synapse    multiple    mapping    neuroanatomical    individual    diseases    maps    disorders    shown    schizophrenia    revealed    discovery    synaptome    catalogues    charts    understand    anatomical    markers    robustly    complexity    normal    community    spatial    platform    central   

Project "SYNNOVATE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://synaptome.genes2cognition.org/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 2˙000˙000.00

Map

 Project objective

Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases. The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses. This has led to the recognition that “synaptome mapping” needs to be developed where the expression level of individual proteins is robustly measured in individual synapses across the whole brain. We developed a novel and unique ‘synaptome discovery and imaging platform’ that links the molecular organisation of synapses with the spatial and temporal anatomical diversity of individual synapses and charts molecular synaptome maps across the brain. This platform enables routine and rapid quantification of genetically encoded molecular markers, with multiple functionalities, in almost a billion synapses in hundreds of brain regions of the mouse and generates statistically robust synapse catalogues and molecular maps of the brain. We have uncovered remarkable new neuroanatomical features and revealed a synaptic molecular architecture at the systems-wide scale. We have discovered this architecture is radically reorganised by mutations that cause schizophrenia, intellectual disability and autism. We have also shown these new methods can label activity-dependent reorganisation of single synapses at a whole brain scale, enabling the tracing of synaptic memory engrams. Our goals are to understand how synaptome maps develop and are reorganized by mutations causing cognitive disorders; examine experience-dependent map plasticity during development, following learning and electrophysiological stimulation in normal animals and those carrying cognitive disorder mutations. We also plan to develop computational approaches based on synaptome maps and freely distribute genetic and image analysis tools to promote synaptome mapping in the community.

 Publications

year authors and title journal last update
List of publications.
2018 Fei Zhu, Mélissa Cizeron, Zhen Qiu, Ruth Benavides-Piccione, Maksym V. Kopanitsa, Nathan G. Skene, Babis Koniaris, Javier DeFelipe, Erik Fransén, Noboru H. Komiyama, Seth G.N. Grant
Architecture of the Mouse Brain Synaptome
published pages: 781-799, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.07.007
Neuron 99 2020-03-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNNOVATE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNNOVATE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HSS (2020)

Homomorphic Secret Sharing: Secure Computation and Beyond

Read More  

CURVE-X (2019)

Industrialisation of curved sensors and related imagers

Read More  

SUBMODULAR (2019)

The Power of Randomness and Continuity in Submodular Optimization

Read More