Explore the words cloud of the PAIN-Net project. It provides you a very rough idea of what is the project "PAIN-Net" about.
The following table provides information about the project.
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA
|Coordinator Country||Italy [IT]|
|Total cost||3˙335˙316 €|
|EC max contribution||3˙335˙316 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-02-01 to 2021-01-31|
Take a look of project's partnership.
|1||FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA||IT (MILANO)||coordinator||258˙061.00|
|2||CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE||FR (ILLKIRCH GRAFFENSTADEN)||participant||788˙626.00|
|3||UNIVERSITEIT MAASTRICHT||NL (MAASTRICHT)||participant||510˙748.00|
|4||NEUROSCIENCE TECHNOLOGIES SLP||ES (Barcelona)||participant||495˙745.00|
|5||ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA||IT (BOLOGNA)||participant||258˙061.00|
|6||DI.V.A.L. TOSCANA SRL||IT (SESTO FIORENTINO FI)||participant||258˙061.00|
|7||FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI||IT (Milan)||participant||258˙061.00|
|8||OSPEDALE SAN RAFFAELE SRL||IT (MILANO)||participant||258˙061.00|
|9||YALE UNIVERSITY||US (NEW HAVEN)||participant||249˙888.00|
|10||NSGENE AS||DK (BALLERUP)||participant||0.00|
|11||CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE)||UK (CAMBRIDGE)||partner||0.00|
|12||CFc srl||IT (MILANO)||partner||0.00|
Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.
|Supervisory Board of the network||Other||2020-04-08 09:54:21|
|Public engagement & dissemination plan||Other||2020-04-08 09:54:21|
|Recruitment report||Other||2020-04-08 09:54:21|
Take a look to the deliverables list in detail: detailed list of PAIN-Net deliverables.
|year||authors and title||journal||last update|
B. T. A. de Greef, J. G. J. Hoeijmakers, C. M. L. Gorissen-Brouwers, M. Geerts, C. G. Faber, I. S. J. Merkies
Associated conditions in small fiber neuropathy - a large cohort study and review of the literature
published pages: 348-355, ISSN: 1351-5101, DOI: 10.1111/ene.13508
|European Journal of Neurology 25/2||2020-04-08|
Ivo Eijkenboom, Maurice Sopacua, Janneke G J Hoeijmakers, Bianca T A de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J M Smeets, Stephen G Waxman, Giuseppe Lauria, Ingemar S J Merkies, Catharina G Faber, Monique M Gerrits
Yield of peripheral sodium channels gene screening in pure small fibre neuropathy
published pages: 342-352, ISSN: 0022-3050, DOI: 10.1136/jnnp-2018-319042
|Journal of Neurology, Neurosurgery & Psychiatry 90/3||2020-04-08|
Margherita Marchi, Vincenzo Provitera, Maria Nolano, Marcello Romano, Simona Maccora, Ilaria D\'Amato, Erika Salvi, Monique Gerrits, Lucio Santoro, Giuseppe Lauria
A novel SCN9A splicing mutation in a compound heterozygous girl with congenital insensitivity to pain, hyposmia and hypogeusia
published pages: 202-206, ISSN: 1085-9489, DOI: 10.1111/jns.12280
|Journal of the Peripheral Nervous System 23/3||2020-04-08|
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