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PAIN-Net SIGNED

Molecule-to-man pain network

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "PAIN-Net" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA 

Organization address
address: VIA GIOVANNI CELORIA 11
city: MILANO
postcode: 20133
website: www.istituto-besta.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.pain-net.eu
 Total cost 3˙335˙316 €
 EC max contribution 3˙335˙316 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA IT (MILANO) coordinator 258˙061.00
2    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 788˙626.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 510˙748.00
4    NEUROSCIENCE TECHNOLOGIES SLP ES (Barcelona) participant 495˙745.00
5    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 258˙061.00
6    DI.V.A.L. TOSCANA SRL IT (SESTO FIORENTINO FI) participant 258˙061.00
7    FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI IT (Milan) participant 258˙061.00
8    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 258˙061.00
9    YALE UNIVERSITY US (NEW HAVEN) participant 249˙888.00
10    NSGENE AS DK (BALLERUP) participant 0.00
11    CAREERS RESEARCH AND ADVISORY CENTRE (CRAC) LIMITED (THE) UK (CAMBRIDGE) partner 0.00
12    CFc srl IT (MILANO) partner 0.00

Map

 Project objective

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.

 Deliverables

List of deliverables.
Supervisory Board of the network Other 2020-04-08 09:54:21
Public engagement & dissemination plan Other 2020-04-08 09:54:21
Recruitment report Other 2020-04-08 09:54:21

Take a look to the deliverables list in detail:  detailed list of PAIN-Net deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 B. T. A. de Greef, J. G. J. Hoeijmakers, C. M. L. Gorissen-Brouwers, M. Geerts, C. G. Faber, I. S. J. Merkies
Associated conditions in small fiber neuropathy - a large cohort study and review of the literature
published pages: 348-355, ISSN: 1351-5101, DOI: 10.1111/ene.13508
European Journal of Neurology 25/2 2020-04-08
2019 Ivo Eijkenboom, Maurice Sopacua, Janneke G J Hoeijmakers, Bianca T A de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J M Smeets, Stephen G Waxman, Giuseppe Lauria, Ingemar S J Merkies, Catharina G Faber, Monique M Gerrits
Yield of peripheral sodium channels gene screening in pure small fibre neuropathy
published pages: 342-352, ISSN: 0022-3050, DOI: 10.1136/jnnp-2018-319042
Journal of Neurology, Neurosurgery & Psychiatry 90/3 2020-04-08
2018 Margherita Marchi, Vincenzo Provitera, Maria Nolano, Marcello Romano, Simona Maccora, Ilaria D\'Amato, Erika Salvi, Monique Gerrits, Lucio Santoro, Giuseppe Lauria
A novel SCN9A splicing mutation in a compound heterozygous girl with congenital insensitivity to pain, hyposmia and hypogeusia
published pages: 202-206, ISSN: 1085-9489, DOI: 10.1111/jns.12280
Journal of the Peripheral Nervous System 23/3 2020-04-08

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The information about "PAIN-NET" are provided by the European Opendata Portal: CORDIS opendata.

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