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SPLICECODE SIGNED

Alternative Splicing Codes for Synaptic Specificity

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EC-Contrib. €

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Project "SPLICECODE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://scheiffele-splice.scicore.unibas.ch/
 Total cost 2˙496˙460 €
 EC max contribution 2˙496˙460 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 2˙496˙460.00

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 Project objective

Neuronal networks represent an impressive example of highly organized complex systems. Sperry postulated that selective neuronal connectivity is achieved by chemoaffinity labels. Several such labels for axon guidance and topographic mapping have been defined. However, until recently, molecules that direct the recognition of synaptic partners and functional specification of synapses have remained obscure.

Chemoaffinity tags are envisioned to provide a recognition code that would encompass the recognition of self versus non-self, recognition of sister cells, and recognition of appropriate and inappropriate synaptic partners. Key parameters that determine the function of recognition systems are the diversity (number of independently recognizable tags), the repertoires of recognition tags in a cell population, and the contribution of tags to selective interactions. The finite number of protein-coding genes in the human genome severely limits the genetic resources that can be employed for generating molecular diversity. In this project we will test the hypothesis that alternative splicing is a central mechanism for the amplification of molecular diversity in recognition tags and their role in synaptic specificity. We will implement novel mass-spectrometry and sequencing methods to define molecular diversity of a highly diversified receptor family in mice. We will unravel the logic of receptor repertoires across cell populations and test the importance of cell type-specific alternative splicing programs for synaptic specificity.

The focus of this project on cell-type specific alternative splicing advances a new dimension in neuronal transcriptomics. Discoveries and technical innovations made in this work should be applicable to molecular studies of recognition events in any system. Finally, human genetic studies link mutations in the gene families explored here to autism. Thus, insights from this work will facilitate analysis of the pathophysiology of this disorder.

 Publications

year authors and title journal last update
List of publications.
2019 Yoko Iijima, Masami Tanaka, Satoko Suzuki, David Hauser, Masayuki Tanaka, Chisa Okada, Masatoshi Ito, Noriko Ayukawa, Yuji Sato, Masato Ohtsuka, Peter Scheiffele, Takatoshi Iijima
SAM68-specific splicing is required for proper selection of alternative 3’UTR isoforms in the nervous system
published pages: , ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.11.028
iScience 2019-11-26
2017 Oriane Mauger, Peter Scheiffele
Beyond proteome diversity: alternative splicing as a regulator of neuronal transcript dynamics
published pages: 162-168, ISSN: 0959-4388, DOI: 10.1016/j.conb.2017.05.012
Current Opinion in Neurobiology 45 2019-06-13
2016 L. Traunmuller, A. M. Gomez, T.-M. Nguyen, P. Scheiffele
Control of neuronal synapse specification by a highly dedicated alternative splicing program
published pages: 982-986, ISSN: 0036-8075, DOI: 10.1126/science.aaf2397
Science 352/6288 2019-06-13
2016 Thi-Minh Nguyen, Dietmar Schreiner, Le Xiao, Lisa Traunmüller, Caroline Bornmann, Peter Scheiffele
An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.22757
eLife 5 2019-06-13
2016 Oriane Mauger, Frédéric Lemoine, Peter Scheiffele
Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity
published pages: 1266-1278, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.11.032
Neuron 92/6 2019-06-13
2019 Zeynep Okur, Peter Scheiffele
The Yin and Yang of Arnt2 in Activity-Dependent Transcription
published pages: 270-272, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.04.006
Neuron 102/2 2019-08-06
2019 Susanne Falkner, Peter Scheiffele
Architects of neuronal wiring
published pages: 437-438, ISSN: 0036-8075, DOI: 10.1126/science.aax3221
Science 364/6439 2019-08-06
2019 Tevye Jason Stachniak, Emily Lauren Sylwestrak, Peter Scheiffele, Benjamin J. Hall, Anirvan Ghosh
Elfn1-induced constitutive activation of mGluR7 determines frequency-dependent recruitment of SOM interneurons
published pages: 2276-18, ISSN: 0270-6474, DOI: 10.1523/jneurosci.2276-18.2019
The Journal of Neuroscience 2019-08-06

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