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Hidden life

Host-microbe interactions involving microbial dark matter: Biology and evolution of a ubiquitous group of intracellular bacteria.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Hidden life project word cloud

Explore the words cloud of the Hidden life project. It provides you a very rough idea of what is the project "Hidden life" about.

candidate    poorly    lifestyle    laboratory    man    eukaryotic    interactions    co    urgently    sequence    bioinformatics    observations    89    substantial    strategies    living    mdm    bacteria    life    biology    worldwide    symbioses    unexplored    dark    species    symbiotic    me    microbial    first    environments    amoeba    isolated    globally    isolate    biological    hosts    elusive    microbes    successful    line    diverse    suggests    uncultivated    amoebae    form    facilitated    frequently    resolution    made    uncover    genomics    phyla    infect    lack    cultivate    undoubtedly    tm6    position    suggested    excellent    members    harbouring    accumulating    innovative    naturally    microscopy    ubiquitous    ecology    genome    confirmed    thrive    earth    natural    bacterium    representative    group    fraction    intracellular    phylum    time    metatranscriptomics    free    cultivation    place    detected    super    protist    kingdom    career    microbe    thought    proteomics    endosymbionts    host    cultivated    cultivable   

Project "Hidden life" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.researchgate.net/project/Hidden-life-Host-microbe-interactions-involving-microbial-dark-matter-Biology-and-evolution-of-a-ubiquitous-group-of-intracellular-bacteria
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 178˙156.00

Map

 Project objective

The kingdom Bacteria represents the most widespread and diverse life form on Earth. On the 89 recognized bacteria phyla, 60 lack a cultivable representative, being thus considered as candidate phyla, or “microbial dark matter” (MDM). Accumulating evidence suggests that a substantial fraction of these elusive microbes is associated with (eukaryotic) hosts. The candidate phylum TM6 represents a major MDM phylum; its members are globally widespread and frequently detected in natural and man-made environments. The draft genome sequence of an uncultivated TM6 member suggested a potential symbiotic lifestyle with protist hosts. This was recently confirmed with the first TM6 isolate obtained by co-cultivation with amoebae. In line with these observations, I recently isolated and cultivated a free-living amoeba species naturally harbouring TM6 bacteria as endosymbionts, making it the first TM6 bacterium isolated with its natural host, and the second worldwide to be cultivated in laboratory conditions. While members of the TM6 phylum are ubiquitous and thought to be involved in major biological processes, their ecology and biology remain at this time unexplored. Through the use of state-of-the-art genomics, bioinformatics, super resolution microscopy, proteomics and innovative metatranscriptomics approaches, I aim to uncover the ecology and biology of TM6 bacteria. The proposed research, facilitated by my ability to cultivate TM6 bacteria within their natural hosts in laboratory conditions, is relevant and urgently needed, because i) it will improve our general understanding of MDM’s poorly known ecology, and ii) it will help uncover the lifestyle of a ubiquitous group of intracellular microbes, their strategies to infect and thrive within eukaryotic hosts. Carrying out this project will undoubtedly place me in an excellent position to develop a successful and top-level career in the field of host-microbe interactions and symbioses.

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The information about "HIDDEN LIFE" are provided by the European Opendata Portal: CORDIS opendata.

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