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Hidden life

Host-microbe interactions involving microbial dark matter: Biology and evolution of a ubiquitous group of intracellular bacteria.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Hidden life project word cloud

Explore the words cloud of the Hidden life project. It provides you a very rough idea of what is the project "Hidden life" about.

symbiotic    isolated    environments    strategies    lifestyle    species    members    successful    suggests    diverse    intracellular    cultivate    form    poorly    first    biology    unexplored    suggested    elusive    place    kingdom    microbe    excellent    hosts    representative    dark    earth    man    thrive    eukaryotic    bioinformatics    candidate    accumulating    frequently    free    microscopy    protist    89    cultivation    cultivable    undoubtedly    time    innovative    lack    uncover    group    line    biological    genome    confirmed    uncultivated    globally    genomics    natural    observations    laboratory    fraction    me    phylum    worldwide    tm6    metatranscriptomics    super    resolution    isolate    harbouring    amoebae    naturally    career    facilitated    microbial    interactions    ecology    mdm    substantial    infect    ubiquitous    cultivated    co    bacterium    endosymbionts    sequence    amoeba    symbioses    living    thought    phyla    bacteria    life    detected    made    urgently    position    microbes    host    proteomics   

Project "Hidden life" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.researchgate.net/project/Hidden-life-Host-microbe-interactions-involving-microbial-dark-matter-Biology-and-evolution-of-a-ubiquitous-group-of-intracellular-bacteria
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 178˙156.00

Map

 Project objective

The kingdom Bacteria represents the most widespread and diverse life form on Earth. On the 89 recognized bacteria phyla, 60 lack a cultivable representative, being thus considered as candidate phyla, or “microbial dark matter” (MDM). Accumulating evidence suggests that a substantial fraction of these elusive microbes is associated with (eukaryotic) hosts. The candidate phylum TM6 represents a major MDM phylum; its members are globally widespread and frequently detected in natural and man-made environments. The draft genome sequence of an uncultivated TM6 member suggested a potential symbiotic lifestyle with protist hosts. This was recently confirmed with the first TM6 isolate obtained by co-cultivation with amoebae. In line with these observations, I recently isolated and cultivated a free-living amoeba species naturally harbouring TM6 bacteria as endosymbionts, making it the first TM6 bacterium isolated with its natural host, and the second worldwide to be cultivated in laboratory conditions. While members of the TM6 phylum are ubiquitous and thought to be involved in major biological processes, their ecology and biology remain at this time unexplored. Through the use of state-of-the-art genomics, bioinformatics, super resolution microscopy, proteomics and innovative metatranscriptomics approaches, I aim to uncover the ecology and biology of TM6 bacteria. The proposed research, facilitated by my ability to cultivate TM6 bacteria within their natural hosts in laboratory conditions, is relevant and urgently needed, because i) it will improve our general understanding of MDM’s poorly known ecology, and ii) it will help uncover the lifestyle of a ubiquitous group of intracellular microbes, their strategies to infect and thrive within eukaryotic hosts. Carrying out this project will undoubtedly place me in an excellent position to develop a successful and top-level career in the field of host-microbe interactions and symbioses.

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The information about "HIDDEN LIFE" are provided by the European Opendata Portal: CORDIS opendata.

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