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Hidden life

Host-microbe interactions involving microbial dark matter: Biology and evolution of a ubiquitous group of intracellular bacteria.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Hidden life project word cloud

Explore the words cloud of the Hidden life project. It provides you a very rough idea of what is the project "Hidden life" about.

line    group    life    infect    cultivation    undoubtedly    representative    time    cultivated    poorly    tm6    cultivable    natural    kingdom    confirmed    uncover    uncultivated    resolution    laboratory    harbouring    facilitated    phyla    ubiquitous    ecology    successful    members    amoeba    free    symbiotic    globally    earth    intracellular    proteomics    form    observations    excellent    biology    place    made    frequently    unexplored    biological    living    cultivate    co    microbial    89    genome    isolate    bacterium    lack    fraction    suggested    naturally    species    urgently    me    elusive    phylum    thought    microscopy    bioinformatics    endosymbionts    candidate    hosts    isolated    accumulating    strategies    mdm    thrive    genomics    microbe    sequence    dark    metatranscriptomics    worldwide    first    suggests    substantial    innovative    diverse    man    environments    eukaryotic    detected    microbes    amoebae    position    host    career    lifestyle    symbioses    bacteria    interactions    protist    super   

Project "Hidden life" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://www.researchgate.net/project/Hidden-life-Host-microbe-interactions-involving-microbial-dark-matter-Biology-and-evolution-of-a-ubiquitous-group-of-intracellular-bacteria
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 178˙156.00

Map

 Project objective

The kingdom Bacteria represents the most widespread and diverse life form on Earth. On the 89 recognized bacteria phyla, 60 lack a cultivable representative, being thus considered as candidate phyla, or “microbial dark matter” (MDM). Accumulating evidence suggests that a substantial fraction of these elusive microbes is associated with (eukaryotic) hosts. The candidate phylum TM6 represents a major MDM phylum; its members are globally widespread and frequently detected in natural and man-made environments. The draft genome sequence of an uncultivated TM6 member suggested a potential symbiotic lifestyle with protist hosts. This was recently confirmed with the first TM6 isolate obtained by co-cultivation with amoebae. In line with these observations, I recently isolated and cultivated a free-living amoeba species naturally harbouring TM6 bacteria as endosymbionts, making it the first TM6 bacterium isolated with its natural host, and the second worldwide to be cultivated in laboratory conditions. While members of the TM6 phylum are ubiquitous and thought to be involved in major biological processes, their ecology and biology remain at this time unexplored. Through the use of state-of-the-art genomics, bioinformatics, super resolution microscopy, proteomics and innovative metatranscriptomics approaches, I aim to uncover the ecology and biology of TM6 bacteria. The proposed research, facilitated by my ability to cultivate TM6 bacteria within their natural hosts in laboratory conditions, is relevant and urgently needed, because i) it will improve our general understanding of MDM’s poorly known ecology, and ii) it will help uncover the lifestyle of a ubiquitous group of intracellular microbes, their strategies to infect and thrive within eukaryotic hosts. Carrying out this project will undoubtedly place me in an excellent position to develop a successful and top-level career in the field of host-microbe interactions and symbioses.

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The information about "HIDDEN LIFE" are provided by the European Opendata Portal: CORDIS opendata.

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